Human embryonic stem (ES) cells maintained in culture can develop chromosomal abnormalities.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Genomic instability of human embryonic stem cell lines using different passaging culture methods
Molecular Cytogenetics Open Access 23 April 2015
-
Human ESCs predisposition to karyotypic instability: Is a matter of culture adaptation or differential vulnerability among hESC lines due to inherent properties?
Molecular Cancer Open Access 03 October 2008
-
Transcriptional analysis of early lineage commitment in human embryonic stem cells
BMC Developmental Biology Open Access 02 March 2007
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Draper, J.S. et al. Nat. Biotechnol. 22, 53–54 (2004).
Longo, L., Bygrave, A., Grosveld, F.G. & Pandolfi, P.P. Transgenic Res. 6, 321–328 (1997).
Liu, X. et al. Dev. Dyn. 209, 85–91 (1997).
Wilton, L. Prenat. Diagn. 22, 512–518 (2002).
Thomson, J.A. et al. Science 282, 1145–1147 (1998).
Reubinoff, B.E., Pera, M.F., Fong, C.Y., Trounson, A. & Bongso, A. Nat. Biotechnol. 18, 399–404 (2000).
Mitalipova, M. et al. Stem Cells 21, 521–526 (2003).
Hovatta, O. et al. Hum. Reprod. 18, 1404–1409 (2003).
Amit, M. et al. Biol. Reprod. 68, 2150–2156 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pera, M. Unnatural selection of cultured human ES cells?. Nat Biotechnol 22, 42–43 (2004). https://doi.org/10.1038/nbt0104-42
Issue Date:
DOI: https://doi.org/10.1038/nbt0104-42
This article is cited by
-
Genomic instability of human embryonic stem cell lines using different passaging culture methods
Molecular Cytogenetics (2015)
-
The international diffusion of biotechnology: the arrival of developing countries
Journal of Evolutionary Economics (2012)
-
Human ESCs predisposition to karyotypic instability: Is a matter of culture adaptation or differential vulnerability among hESC lines due to inherent properties?
Molecular Cancer (2008)
-
Transcriptional analysis of early lineage commitment in human embryonic stem cells
BMC Developmental Biology (2007)
-
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
Nature Biotechnology (2007)