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2011 | OriginalPaper | Buchkapitel

A Commonly Used Pesticide Endosulfan in Diet Could Cause Hepatomegaly and Kidney Tumor When Combined with Nitrosamines

verfasst von : Recai Ogur, Omer Faruk Tekbas

Erschienen in: Survival and Sustainability

Verlag: Springer Berlin Heidelberg

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Abstract

Pesticides and nitrites which could be available in foods are generally investigated individually, although they could be found in foods together and exhibit combined health effects. In this study we aimed to determine the combined effects of endosulfan which is a commonly used pesticide and N-nitroso-N-methylurea (NMU) which is a prototype for mammary tumor development in Sprague Dawley rats and could be formed in brine foods or also in body from nitrites which is commonly used in meat. Ninety female Sprague Dawley rats had been used. Animals were divided three groups which consisted 30 animals. The first group took a single dose endosulfan intraperitoneal (ip) on 19th day and a single dose NMU ip on 21 day, the second group took endosulfan by their drinking waters for the first 60 days of their life and a single dose NMU ip on 21 day, and the third group took only a single dose NMU ip on 21 day. Animals were controlled for their general health status, mammary mass develeopment, daily water consumption and weekly weight gain. At the end of the study rats were examinated carefully under anesthesia, and tissue samples were prepared from their mammary glands and intraabdominal organs. Tissue samples taken from mammary glands, liver and kidneys were histopathalogically examined. It was determined a statistically significant hepatomegally in the second group when we compared to other groups (p < 0.05). No animals developed mammary tumors. On the macroscopic examination and manual palpation of intraabdominal region, it was showed that solid tumors in kidneys as a ratio of 76.7% of the animals in the second group (bilateral in 1,3% of them, the others are unilaterally and 70% of the unilateral tumors are in the left kidneys while the rest of them are right localized). Also it was found that in the first group, 13.4% of the animals developed unilateral kidney tumors. The third group which had been applied only NMU developed no kidney or liver pathalogy macroscopically. As a result it was considered that a diversity which is named as “genetic shift” could be developed in our animal research center and because of this shift we could not developed NMU induced mammary tumors in our Sprague Dawley rats. But it has been showed that long term endosulfan expose has resulted in kidney tumor development for the first time. Because of the genetic shifting mentioned above, it should be tested whether this experimental animal cancer model is limited for our research center or not by obtaining sprague dawley animals from different centers. Interactions of living style, environmental factors and genetic properties in the development of cancer and its necessary to control all of three factors in order to reduce cancer frequency in public showed that the importance of interdiciplinary collaboration and public education. Consumers and appliers should be educated about using pestices, and healthy and safety food production and concumption should be considered as one of the primary subjects in public health studies.

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Literatur
1.
Zurück zum Zitat Abelsohn A, Gibson BL, Sanborn MD, Weir E (2002) Identifying and managing adverse environmental health effects: 5. Persistent organic pollutants. Can Med Assoc J 166(12):1549–1554 Abelsohn A, Gibson BL, Sanborn MD, Weir E (2002) Identifying and managing adverse environmental health effects: 5. Persistent organic pollutants. Can Med Assoc J 166(12):1549–1554
2.
Zurück zum Zitat Adeoya-Osiguwa SA, Markoulaki S, Pocock V, Milligan SR, Fraser LR (2003) 17beta-estradiol and environmental estrogens significantly affect mammalian sperm function. Hum Reprod 18(1):100–107CrossRef Adeoya-Osiguwa SA, Markoulaki S, Pocock V, Milligan SR, Fraser LR (2003) 17beta-estradiol and environmental estrogens significantly affect mammalian sperm function. Hum Reprod 18(1):100–107CrossRef
3.
Zurück zum Zitat Ahlbom J, Fredriksson A, Eriksson P (1995) Exposure to an organophosphate (DFP) during a defined period in neonatal life induces permanent changes in brain muscarinic receptors and behavior in adult mice. Brain Res 677:13–19CrossRef Ahlbom J, Fredriksson A, Eriksson P (1995) Exposure to an organophosphate (DFP) during a defined period in neonatal life induces permanent changes in brain muscarinic receptors and behavior in adult mice. Brain Res 677:13–19CrossRef
4.
Zurück zum Zitat Carpy SA, Kobel W, Doe J (2000) Health risk of low-dose pesticides mixtures: A review of the 1985–1998 literature on combination toxicology and health risk assessment. J Toxicol Environ Health Part B, Crit Rev 3(1):1–25CrossRef Carpy SA, Kobel W, Doe J (2000) Health risk of low-dose pesticides mixtures: A review of the 1985–1998 literature on combination toxicology and health risk assessment. J Toxicol Environ Health Part B, Crit Rev 3(1):1–25CrossRef
5.
Zurück zum Zitat Aguilera-Del AR, Valverde-Garcia A, Fernandez-Alba AR, Camacho-Ferre F (1997) Behaviour of endosulfan residues in peppers, cucumbers and cherry tomatoes grown in greenhouse: Evaluation of decline curves. Pest Sci 51:194–200CrossRef Aguilera-Del AR, Valverde-Garcia A, Fernandez-Alba AR, Camacho-Ferre F (1997) Behaviour of endosulfan residues in peppers, cucumbers and cherry tomatoes grown in greenhouse: Evaluation of decline curves. Pest Sci 51:194–200CrossRef
6.
Zurück zum Zitat Amaraneni SR (2002) Persistence of pesticides in water, sediment and fish from fish farms in Kolleru Lake, India. J Sci Food Agric 82(8):918–923CrossRef Amaraneni SR (2002) Persistence of pesticides in water, sediment and fish from fish farms in Kolleru Lake, India. J Sci Food Agric 82(8):918–923CrossRef
7.
Zurück zum Zitat Archibeque-Engle SL, Tessari JD, Winn DT, Kefe TJ, Nett TM, Zheng T (1997) Comparison of organochlorine pesticide and polychlorinated biphenyl residues in human breast adipose tissue and serum. J Toxicol Environ Health 52:285–293CrossRef Archibeque-Engle SL, Tessari JD, Winn DT, Kefe TJ, Nett TM, Zheng T (1997) Comparison of organochlorine pesticide and polychlorinated biphenyl residues in human breast adipose tissue and serum. J Toxicol Environ Health 52:285–293CrossRef
8.
Zurück zum Zitat Arrebola FJ, Egea-Gonzalez FJ, Moreno M, Fernandez-Gutierrez A, Hernandez-Torres ME, Martinez-Vidal JL (2001) Evaluation of endosulfan residues in vegetables grown in greenhouses. Pest Manage Sci 57(7):645–652CrossRef Arrebola FJ, Egea-Gonzalez FJ, Moreno M, Fernandez-Gutierrez A, Hernandez-Torres ME, Martinez-Vidal JL (2001) Evaluation of endosulfan residues in vegetables grown in greenhouses. Pest Manage Sci 57(7):645–652CrossRef
9.
Zurück zum Zitat Cerrillo I, Granada A, Lopez-Espinosa MJ, Olmos B, Jimenez M, Cano A, Olea N, Olea-Serrano MF (2005) Endosulfan and its metabolites in fertile women, placenta, cord blood, and human milk. Environ Res 98(2):233–239CrossRef Cerrillo I, Granada A, Lopez-Espinosa MJ, Olmos B, Jimenez M, Cano A, Olea N, Olea-Serrano MF (2005) Endosulfan and its metabolites in fertile women, placenta, cord blood, and human milk. Environ Res 98(2):233–239CrossRef
10.
Zurück zum Zitat Safi JM, Abou-Foul NS, el-Nahhal YZ, el-Sebae AH (2002) Monitoring of pesticide residues on cucumber, tomatoes and strawberries in Gaza Governorates, Palestine. Nahrung 46(1):34–39CrossRef Safi JM, Abou-Foul NS, el-Nahhal YZ, el-Sebae AH (2002) Monitoring of pesticide residues on cucumber, tomatoes and strawberries in Gaza Governorates, Palestine. Nahrung 46(1):34–39CrossRef
11.
Zurück zum Zitat Barnard RJ (2004) Prevention of cancer through lifestyle changes. Evidence Based Complement Altern Med 1(3):233–239CrossRef Barnard RJ (2004) Prevention of cancer through lifestyle changes. Evidence Based Complement Altern Med 1(3):233–239CrossRef
13.
Zurück zum Zitat Calle EE, Frumkin H, Henley SJ, Savitz DA, Thun MJ (2002) Organochlorines and breast cancer risk. CA Cancer J Clin 52(5):301–309CrossRef Calle EE, Frumkin H, Henley SJ, Savitz DA, Thun MJ (2002) Organochlorines and breast cancer risk. CA Cancer J Clin 52(5):301–309CrossRef
14.
Zurück zum Zitat Johnson FM (2002) How many food additives are rodent carcinogens? Environ Mol Mutagen 39(1):69–80CrossRef Johnson FM (2002) How many food additives are rodent carcinogens? Environ Mol Mutagen 39(1):69–80CrossRef
15.
Zurück zum Zitat Macejova D, Brtko J (2001) Chemically induced carcinogenesis: a comparison of 1-methyl-1-nitrosourea, 7,12-dimethylbenzanthracene,diethylnitroso-amine and azoxymethan models (minireview). Endocr Regul 35(1):53–59 Macejova D, Brtko J (2001) Chemically induced carcinogenesis: a comparison of 1-methyl-1-nitrosourea, 7,12-dimethylbenzanthracene,diethylnitroso-amine and azoxymethan models (minireview). Endocr Regul 35(1):53–59
16.
Zurück zum Zitat McCormick DL, Adamowski CB, Fiks A, Moon RC (1981) Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea. Cancer Res 41(5):1690–1694 McCormick DL, Adamowski CB, Fiks A, Moon RC (1981) Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea. Cancer Res 41(5):1690–1694
17.
Zurück zum Zitat Festing MFW, Altman DG (2002) Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR J 43(4):244–258 Festing MFW, Altman DG (2002) Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR J 43(4):244–258
18.
Zurück zum Zitat Masso-Welch PA, Darcy KM, Stangle-Castor NC, Ip MM (2000) A developmental atlas of rat mammary gland histology. J Mammary Gland Biol Neoplasia 5(2):165–185CrossRef Masso-Welch PA, Darcy KM, Stangle-Castor NC, Ip MM (2000) A developmental atlas of rat mammary gland histology. J Mammary Gland Biol Neoplasia 5(2):165–185CrossRef
19.
Zurück zum Zitat Russo J, Russo IH (2000) Atlas and histologic classification of tumors of the rat mammary gland. J Mammary Gland Biol Neoplasia 5(2):187–200CrossRef Russo J, Russo IH (2000) Atlas and histologic classification of tumors of the rat mammary gland. J Mammary Gland Biol Neoplasia 5(2):187–200CrossRef
20.
Zurück zum Zitat Chou YC, Guzman RC, Swanson SM, Yang J, Lui HM, Wu V, Nandi S (1999) Induction of mammary carcinomas by N-methyl-N-nitrosourea in ovariectomized rats treated with epidermal growth factor. Carcinogenesis 20(4):677–684CrossRef Chou YC, Guzman RC, Swanson SM, Yang J, Lui HM, Wu V, Nandi S (1999) Induction of mammary carcinomas by N-methyl-N-nitrosourea in ovariectomized rats treated with epidermal growth factor. Carcinogenesis 20(4):677–684CrossRef
21.
Zurück zum Zitat Hu L, Lin L, Crist KA, Kelloff GJ, Steele VE, Lubet RA, You M, Wang Y (1997) Detection of differentially expressed genes in methylnitrosourea-induced rat mammary adenocarcinomas. J Cell Biochem Suppl 28–29:117–124CrossRef Hu L, Lin L, Crist KA, Kelloff GJ, Steele VE, Lubet RA, You M, Wang Y (1997) Detection of differentially expressed genes in methylnitrosourea-induced rat mammary adenocarcinomas. J Cell Biochem Suppl 28–29:117–124CrossRef
22.
Zurück zum Zitat Bailey DW (1977) Genetic drift: the problem and its possible solution by frozen-embryo storage. Ciba Found Symp 291–303 Bailey DW (1977) Genetic drift: the problem and its possible solution by frozen-embryo storage. Ciba Found Symp 291–303
23.
Zurück zum Zitat Bailey DW (1982) How pure are inbred strains of mice? Immunol Today 3:210–214CrossRef Bailey DW (1982) How pure are inbred strains of mice? Immunol Today 3:210–214CrossRef
24.
Zurück zum Zitat Ames BN, Gold LS (1998) The causes and prevention of cancer: the role of environment. Biotherapy 11(2–3):205–220CrossRef Ames BN, Gold LS (1998) The causes and prevention of cancer: the role of environment. Biotherapy 11(2–3):205–220CrossRef
Metadaten
Titel
A Commonly Used Pesticide Endosulfan in Diet Could Cause Hepatomegaly and Kidney Tumor When Combined with Nitrosamines
verfasst von
Recai Ogur
Omer Faruk Tekbas
Copyright-Jahr
2011
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-540-95991-5_54