nach oben

Erschienen in:

01.04.2013

A descriptive analysis of quality of life using patient-reported measures in major depressive disorder in a naturalistic outpatient setting

verfasst von: Waguih William IsHak, Konstantin Balayan, Catherine Bresee, Jared Matt Greenberg, Hala Fakhry, Scott Christensen, Mark Hyman Rapaport

Erschienen in: Quality of Life Research | Ausgabe 3/2013

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Purpose

Major depressive disorder (MDD) negatively impacts different aspects of an individual’s life leading to grave impairments in quality of life (QOL). We performed a detailed analysis of the interaction between depressive symptom severity, functioning, and QOL in outpatients with MDD in order to better understand QOL impairments in MDD.

Methods

This cross-sectional study was conducted with 319 consecutive outpatients seeking treatment for DSM-IV-diagnosed MDD at an urban hospital-based outpatient clinic from 2005 to 2008 as part of the Cedars-Sinai Psychiatric Treatment Outcome Registry, a prospective cohort study of clinical, functioning, and patient-reported QOL outcomes in psychiatric disorders using a measurement-based care model. This model utilizes the following measures: (a) Depressive symptom severity: Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR); (b) Functioning measures: Global Assessment of Functioning (GAF), Sheehan Disability Scale (SDS), Work and Social Adjustment Scale, and the Endicott Work Productivity Scale; and (c) Quality of Life measure: Quality of Life, Enjoyment, and Satisfaction Questionnaire—Short Form (Q-LES-Q).

Results

QOL is significantly impaired in MDD, with a mean Q-LES-Q score for this study population of 39.8 % (SD = 16.9), whereas the community norm average is 78.3 %. Regression modeling suggested that depressive symptom severity, functioning/disability, and age all significantly contributed to QOL. QIDS-SR (measuring depressive symptom severity), GAF, and SDS (measuring functioning/disability) scores accounted for 48.1, 17.4, and 13.3 % (semi-partial correlation values) of the variance in Q-LES-Q, respectively.

Conclusions

Our results show that impairment of QOL increases in a monotonic fashion with depressive symptom severity; however, depression symptom severity only accounted for 48.1 % of the QOL variance in our patient population. Furthermore, QOL is uniquely associated with measures of Functioning. We believe these results demonstrate the need to utilize not only Symptom Severity scales, but also Functioning and Quality of Life measures in MDD assessment, treatment, and research.

Vorheriger Artikel The quality of life of adults with type 2 diabetes in a hospital care clinic in Taiwan

Nächster Artikel Depression and anxiety symptoms in bronchiectasis: associations with health-related quality of life

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Constitution of the World Health Organization. (1946). American Journal of Public Health and the Nation’s Health, 36(11): 1315–1323.

Bonicatto, S. C., Dew, M. A., Zaratiegui, R., Lorenzo, L., & Pecina, P. (2001). Adult outpatients with depression: Worse quality of life than in other chronic medical diseases in Argentina. Social Science and Medicine, 52(6), 911–919.PubMedCrossRef

Papakostas, G. I., Petersen, T., Mahal, Y., Mischoulon, D., Nierenberg, A. A., & Fava, M. (2004). Quality of life assessments in major depressive disorder: A review of the literature. General Hospital Psychiatry, 26, 13–17.PubMedCrossRef

Doraiswamy, P., Khan, Z. M., Donahue, J., & Richard, N. E. (2002). The spectrum of quality-of-life impairments in recurrent geriatric depression. Journal of Gerontology: Medical Sciences., 57A, M134–M137.CrossRef

Saarijarvi, S., Salminen, J. K., Toikka, T., & Raitasalo, R. (2002). Health-related quality of life among patients with major depression. Nordic Journal of Psychiatry, 56(4), 261–264.PubMedCrossRef

Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Warden, D., McKinney, W., Downing, M., et al. (2006). Factors associated with health-related quality of life among outpatients with major depressive disorder: A STAR*D report. Journal of Clinical Psychiatry, 67(2), 185–195.PubMedCrossRef

Rapaport, M. H., Clary, C., Fayyad, R., & Endicott, J. (2005). Quality-of-life impairment in depressive and anxiety disorders. American Journal of Psychiatry, 162, 1171–1178.PubMedCrossRef

Rush, A. J., & Trivedi, M. H. (1995). Treating depression to remission. Psychiatric Annals, 25, 704–709.

Zimmerman, M., Mattia, J. I., & Posternak, M. A. (2002). Are subjects in pharmacological treatment trials of depression representative of patients in routine clinical practice? American Journal of Psychiatry, 159, 469–473.PubMedCrossRef

10.

Angst, J., Kupfer, D. J., & Rosenbaum, J. F. (1996). Recovery from depression: Risk or reality? Acta Psychiatrica Scandinavica, 93, 413–419.PubMedCrossRef

11.

Rapaport, M. H. (2009). Helping patients with depression achieve wellness. Journal of Clinical Psychiatry, 70(5), e11.PubMedCrossRef

12.

Sheehan, D. V., Lecrubier, Y., Sheehan, K. H., Amorim, P., Janavs, J., Weiller, E., et al. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 59(Suppl 20), 22–33; quiz 34–57.

13.

Rush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., et al. (2003). The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): A psychometric evaluation in patients with chronic major depression. Biological Psychiatry, 54(5), 585.CrossRef

14.

Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56(6), 893–897.PubMedCrossRef

15.

American Psychiatric Association. (1994). Global Assessment of Functioning in diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Publishing Inc.

16.

Sheehan, D. V. (1983). The anxiety disease. New York, NY: Scribner’s.

17.

Mundt, J. C., Marks, I. M., Shear, M. K., & Greist, J. H. (2002). The Work and Social Adjustment Scale: A simple measure of impairment in functioning. British Journal of Psychiatry, 180, 461–464.PubMedCrossRef

18.

Endicott, J., Nee, J., Harrison, W., & Blumenthal, R. (1993). Quality of life enjoyment and satisfaction questionnaire: A new measure. Psychopharmacology Bulletin, 29, 321–326.PubMed

19.

Schechter, D., Endicott, J., Nee, J. (2007). Quality of life of ‘normal’ controls: Association with lifetime history of mental illness. Psychiatry Research, 30 152(1):45–54.

20.

Beck, A. T., & Steer, R. A. (1990). Beck Anxiety Inventory manual. San Antonio, TX: Psychological Corporation.

21.

Fava, M., Rush, A. J., Alpert, J. E., Balasubramani, G. K., Wisniewski, S. R., Carmin, C. N., et al. (2008). Difference in treatment outcome in outpatients with anxious versus nonanxious depression: A STAR*D report. American Journal of Psychiatry, 165(3), 342–351.PubMedCrossRef

22.

Reed, C., Monz, B. U., Perahia, D. G., Gandhi, P., Bauer, M., Dantchev, N., et al. (2009). Quality of life outcomes among patients with depression after 6 months of starting treatment: Results from FINDER. Journal of Affective Disorders, 113(3), 296–302.PubMedCrossRef

23.

Fleck, M., Simon, G., & Herrman, H. (2005). Major Depression and its correlates in primary care settings in six countries. British Journal of Psychiatry, 186(1), 41–47.CrossRef

24.

Wisniewski, S. R., Rush, A. J., Bryan, C., Shelton, R., Trivedi, M. H., Marcus, S., et al. (2007). Comparison of quality of life measures in a depressed population. Journal of Nervous and Mental Disease, 195(3), 219–225.PubMedCrossRef

25.

Daly, E. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Gaynes, B. N., Warden, D., et al. (2010). Health-related quality of life in depression: A STAR*D report. Annals of Clinical Psychiatry, 22(1), 43–55.PubMed

26.

Piccinelli, M., & Wilkinson, G. (2000). Gender differences in depression. Critical review. British Journal of Psychiatry, 177, 486–492.PubMedCrossRef

27.

Fava, M., Alpert, J. E., Carmin, C. N., Wisniewski, S. R., Trivedi, M. H., Biggs, M. M., et al. (2004). Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D. Psychological Medicine, 34(7), 1299–1308.PubMedCrossRef

28.

Berlim, M. T., McGirr, A., & Fleck, M. P. (2008). Can sociodemographic and clinical variables predict the quality of life of outpatients with major depression? Psychiatry Research, 160(3), 364–371.PubMedCrossRef

29.

da Rocha, N. S., Power, M. J., Bushnell, D. M., & Fleck, M. P. (2009). Is there a measurement overlap between depressive symptoms and quality of life? Comprehensive Psychiatry, 50(6), 549–555.PubMedCrossRef

30.

Gureje, O., Kola, L., Afolabi, E., & Olley, B. O. (2008). Determinants of quality of life of elderly Nigerians: Results from the Ibadan study of ageing. African Journal of Medicine and Medical Sciences, 37(3), 239–247.PubMed

31.

Moore, M., Hofer, S., McGee, H., & Ring, L. (2005). Can the concept of depression and quality of life be integrated using a time perspective? Health and Quality of Life Outcomes, 5, 3–11.

32.

Ritsner, M. (2007). The distress/protection vulnerability model of quality of life impairment syndrome. In M. Ritsner & A. G. Awad (Eds.). Quality of life impairment in schizophrenia, mood, and anxiety disorders (pp. 3–19). The Netherlands: Springer.

33.

Bech, P. (1995). Quality-of-life measurements for patients taking which drugs? The clinical PCASEE perspective. Pharmacoeconomics, 7(2), 141–151.PubMedCrossRef

34.

Yen, C. F., Chen, C. C., Lee, Y., Tang, T. C., Ko, C. H., & Yen, J. Y. (2009). Association between quality of life and self-stigma, insight, and adverse effects of medication in patients with depressive disorders. Depression and Anxiety, 26(11), 1033–1039.PubMedCrossRef

35.

Skevington, S. M., Lotfy, M., O’Connell, K. A., & WHOQOL Group. (2004). The World Health Organization’s WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A report from the WHOQOL group. Quality of Life Research, 13, 299–310.PubMedCrossRef

36.

Kessler, R. C., Zhao, S., Blazer, D. G., & Swartz, M. (1997). Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey. Journal of Affective Disorders, 45, 19–30.PubMedCrossRef

37.

Maier, W., Gansicke, M., & Weiffenbach, O. (1997). The relationship between major and subthreshold variants of unipolar depression. Journal of Affective Disorders, 45, 41–51.PubMedCrossRef

38.

IsHak, W. W., Greenberg, J. M., Balayan, K., Kapitanski, N., Jeffrey, J., Fathy, H., et al. (2011). Quality of life: The ultimate outcome measure of interventions in major depressive disorder. Harvard Review of Psychiatry, 19, 229–239.PubMedCrossRef

Titel: A descriptive analysis of quality of life using patient-reported measures in major depressive disorder in a naturalistic outpatient setting
verfasst von: Waguih William IsHak
Konstantin Balayan
Catherine Bresee
Jared Matt Greenberg
Hala Fakhry
Scott Christensen
Mark Hyman Rapaport
Publikationsdatum: 01.04.2013
Verlag: Springer Netherlands
Erschienen in: Quality of Life Research / Ausgabe 3/2013
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-012-0187-6

Springer Professional

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Wirtschaft"

Weitere Artikel der Ausgabe 3/2013

Socio-behavioral predictors of self-reported oral health-related quality of life

The quality of life of adults with type 2 diabetes in a hospital care clinic in Taiwan

Self-efficacy and adherence as mediating factors between personality traits and health-related quality of life

Erratum to: Assessment of response shift using two structural equation modeling techniques

Single-item electronic administration of the SF-36v2 Health Survey

Psychometric assessment of the patient activation measure short form (PAM-13) in rural settings