Anzeige
Erschienen in:
2010 | OriginalPaper | Buchkapitel
A Formal Model for Gene Regulatory Networks with Time Delays
verfasst von : Jean-Paul Comet, Jonathan Fromentin, Gilles Bernot, Olivier Roux
Erschienen in: Computational Systems-Biology and Bioinformatics
Verlag: Springer Berlin Heidelberg
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
We introduce a hybrid modelling framework for gene regulatory networks as an extension of the René Thomas’ discrete modelling framework. We handle temporal aspects through
delays
expressing the time mandatory to pass from a qualitative state to another one. It permits one to build, from a specification expressed in terms of paths, the constraints on the temporal parameters in order to assure the consistency between the hybrid model and the specification.
We illustrate this modelling framework on the simple system of
mucus
production in the bacterium
Pseudomonas aeruginosa
. We show through this example how to build the constraints on the delays parameters for the specification of a cycle in the dynamics.