Skip to main content

2017 | OriginalPaper | Buchkapitel

A Framework for Automated Knowledge Graph Construction Towards Traditional Chinese Medicine

verfasst von : Heng Weng, Ziqing Liu, Shixing Yan, Meiyu Fan, Aihua Ou, Dacan Chen, Tianyong Hao

Erschienen in: Health Information Science

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Medical knowledge graph can potentially help knowledge discovery from clinical data, assisting clinical decision making and personalized treatment recommendation. This paper proposes a framework for automated medical knowledge graph construction based on semantic analysis. The framework consists of a number of modules including a medical ontology constructor, a knowledge element generator, a structured knowledge dataset generator, and a graph model constructor. We also present the implementation and application of the constructed knowledge graph with the framework for personalized treatment recommendation. Our experiment dataset contains 886 patient records with hypertension. The result shows that the application of the constructed knowledge graph achieves dramatic accuracy improvements, demonstrating the effectiveness of the framework in automated medical knowledge graph construction and application.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Jameson, J.L., Longo, D.L.: Precision medicine-personalized, problematic, and promising. Obstetr. Gynecol. Surv. 70(10), 612–614 (2015)CrossRef Jameson, J.L., Longo, D.L.: Precision medicine-personalized, problematic, and promising. Obstetr. Gynecol. Surv. 70(10), 612–614 (2015)CrossRef
2.
Zurück zum Zitat Raghupathi, W., Raghupathi, V.: Big data analytics in healthcare: promise and potential. Health Inf. Sci. Syst. 2(1), 3 (2014)CrossRef Raghupathi, W., Raghupathi, V.: Big data analytics in healthcare: promise and potential. Health Inf. Sci. Syst. 2(1), 3 (2014)CrossRef
4.
Zurück zum Zitat Sagiroglu, S., Sinanc, D.: Big data: a review. In: Proceedings of International Conference on Collaboration Technologies and Systems, pp. 42–47 (2013) Sagiroglu, S., Sinanc, D.: Big data: a review. In: Proceedings of International Conference on Collaboration Technologies and Systems, pp. 42–47 (2013)
5.
Zurück zum Zitat Belle, A., Thiagarajan, R., Soroushmehr, S., et al.: Big Data Analytics in Healthcare. BioMed Research International (2015) Belle, A., Thiagarajan, R., Soroushmehr, S., et al.: Big Data Analytics in Healthcare. BioMed Research International (2015)
6.
Zurück zum Zitat Alickovic, E., Subasi, A.: Medical decision support system for diagnosis of heart arrhythmia using DWT and random forests classifier. J. Med. Syst. 40(4), 1–12 (2016)CrossRef Alickovic, E., Subasi, A.: Medical decision support system for diagnosis of heart arrhythmia using DWT and random forests classifier. J. Med. Syst. 40(4), 1–12 (2016)CrossRef
7.
Zurück zum Zitat Constantinou, A.C., Fenton, N., Marsh, W., et al.: From complex questionnaire and interviewing data to intelligent Bayesian network models for medical decision support. Artif. Intell. Med. 67, 75–93 (2016)CrossRef Constantinou, A.C., Fenton, N., Marsh, W., et al.: From complex questionnaire and interviewing data to intelligent Bayesian network models for medical decision support. Artif. Intell. Med. 67, 75–93 (2016)CrossRef
8.
Zurück zum Zitat Woosley, R., Whyte, J., Mohamadi, A., et al.: Medical decision support systems and therapeutics: the role of autopilots. Clin. Pharmacol. Ther. 99(2), 161–164 (2016)CrossRef Woosley, R., Whyte, J., Mohamadi, A., et al.: Medical decision support systems and therapeutics: the role of autopilots. Clin. Pharmacol. Ther. 99(2), 161–164 (2016)CrossRef
9.
Zurück zum Zitat Cambria, E., Olsher, D., Rajagopal, D.: SenticNet 3: a common and common-sense knowledge base for cognition-driven sentiment analysis. In: Proceedings of Twenty-Eighth AAAI Conference on Artificial Intelligence (2014) Cambria, E., Olsher, D., Rajagopal, D.: SenticNet 3: a common and common-sense knowledge base for cognition-driven sentiment analysis. In: Proceedings of Twenty-Eighth AAAI Conference on Artificial Intelligence (2014)
10.
Zurück zum Zitat Mirzaa, G.M., Millen, K.J., Barkovich, A.J., et al.: The developmental brain disorders database (DBDB): a curated neurogenetics knowledge base with clinical and research applications. Am. J. Med. Genet. Part A 164(6), 1503–1511 (2014)CrossRef Mirzaa, G.M., Millen, K.J., Barkovich, A.J., et al.: The developmental brain disorders database (DBDB): a curated neurogenetics knowledge base with clinical and research applications. Am. J. Med. Genet. Part A 164(6), 1503–1511 (2014)CrossRef
11.
Zurück zum Zitat Taglang, G.D., Jackson, B.: Use of “big data” in drug discovery and clinical trials. Gynecol. Oncol. 141(1), 17–23 (2016)CrossRef Taglang, G.D., Jackson, B.: Use of “big data” in drug discovery and clinical trials. Gynecol. Oncol. 141(1), 17–23 (2016)CrossRef
12.
Zurück zum Zitat Vicini, P., Fields, O., Lai, E., et al.: Precision medicine in the age of big data: the present and future role of large-scale unbiased sequencing in drug discovery and development. Clin. Pharmacol. Ther. 99(2), 198–207 (2016)CrossRef Vicini, P., Fields, O., Lai, E., et al.: Precision medicine in the age of big data: the present and future role of large-scale unbiased sequencing in drug discovery and development. Clin. Pharmacol. Ther. 99(2), 198–207 (2016)CrossRef
13.
Zurück zum Zitat Holzinger, A.: Trends in interactive knowledge discovery for personalized medicine: cognitive science meets machine learning. IEEE Intell. Inform. Bull. 15(1), 6–14 (2014) Holzinger, A.: Trends in interactive knowledge discovery for personalized medicine: cognitive science meets machine learning. IEEE Intell. Inform. Bull. 15(1), 6–14 (2014)
14.
Zurück zum Zitat Kim, D., Joung, J.G., Sohn, K.A., et al.: Knowledge boosting: a graph-based integration approach with multi-omics data and genomic knowledge for cancer clinical outcome prediction. J. Am. Med. Inform. Assoc. 22(1), 109–120 (2015) Kim, D., Joung, J.G., Sohn, K.A., et al.: Knowledge boosting: a graph-based integration approach with multi-omics data and genomic knowledge for cancer clinical outcome prediction. J. Am. Med. Inform. Assoc. 22(1), 109–120 (2015)
15.
Zurück zum Zitat Kamsu-Foguem, B., Tchuenté-Foguem, G., Foguem, C.: Using conceptual graphs for clinical guidelines representation and knowledge visualization. Inf. Syst. Front. 16(4), 571–589 (2014)CrossRef Kamsu-Foguem, B., Tchuenté-Foguem, G., Foguem, C.: Using conceptual graphs for clinical guidelines representation and knowledge visualization. Inf. Syst. Front. 16(4), 571–589 (2014)CrossRef
16.
Zurück zum Zitat Zhang, D., Xie, Y., Li, M., et al.: Construction of knowledge graph of traditional Chinese medicine based on the ontology. Technol. Intell. Eng. 3(1), 8 (2017) Zhang, D., Xie, Y., Li, M., et al.: Construction of knowledge graph of traditional Chinese medicine based on the ontology. Technol. Intell. Eng. 3(1), 8 (2017)
17.
Zurück zum Zitat Yu, T., Li, J., Yu, Q., et al.: Knowledge graph for TCM health preservation: design, construction, and applications. Artif. Intell. Med. 77, 48–52 (2017)CrossRef Yu, T., Li, J., Yu, Q., et al.: Knowledge graph for TCM health preservation: design, construction, and applications. Artif. Intell. Med. 77, 48–52 (2017)CrossRef
18.
Zurück zum Zitat Shi, L., Li, S., Yang, X., et al.: Semantic Health Knowledge Graph: Semantic Integration of Heterogeneous Medical Knowledge and Services. BioMed Research International (2017) Shi, L., Li, S., Yang, X., et al.: Semantic Health Knowledge Graph: Semantic Integration of Heterogeneous Medical Knowledge and Services. BioMed Research International (2017)
19.
Zurück zum Zitat Mikolov, T., Kombrink, S., Deoras, A., et al.: RNNLM-recurrent neural network language modeling toolkit. In: Proceedings of the 2011 ASRU Workshop, pp. 196–201 (2011) Mikolov, T., Kombrink, S., Deoras, A., et al.: RNNLM-recurrent neural network language modeling toolkit. In: Proceedings of the 2011 ASRU Workshop, pp. 196–201 (2011)
20.
Zurück zum Zitat Ou, A., Lin, X., Li, G., et al.: LEVIS: a hypertension dataset in traditional Chinese medicine. In: Proceedings of Bioinformatics and Biomedicine (BIBM), pp. 192–197 (2013) Ou, A., Lin, X., Li, G., et al.: LEVIS: a hypertension dataset in traditional Chinese medicine. In: Proceedings of Bioinformatics and Biomedicine (BIBM), pp. 192–197 (2013)
21.
Zurück zum Zitat State Administration of Traditional Chinese Medicine of People’s Republic of China: Clinic terminology of traditional Chinese medical diagnosis and treatment–Syndromes. Standards Press of China, Beijing, GB/T 16751.2–1997 (1997) State Administration of Traditional Chinese Medicine of People’s Republic of China: Clinic terminology of traditional Chinese medical diagnosis and treatment–Syndromes. Standards Press of China, Beijing, GB/T 16751.2–1997 (1997)
22.
Zurück zum Zitat Zhang, M.L., Zhou, Z.H.: ML-KNN: a lazy learning approach to multi-label learning. Pattern Recogn. 40(7), 2038–2048 (2007)CrossRefMATH Zhang, M.L., Zhou, Z.H.: ML-KNN: a lazy learning approach to multi-label learning. Pattern Recogn. 40(7), 2038–2048 (2007)CrossRefMATH
23.
Zurück zum Zitat Sorower, M.S.: A Literature Survey on Algorithms for Multi-label Learning. Oregon State University, Corvallis (2010) Sorower, M.S.: A Literature Survey on Algorithms for Multi-label Learning. Oregon State University, Corvallis (2010)
Metadaten
Titel
A Framework for Automated Knowledge Graph Construction Towards Traditional Chinese Medicine
verfasst von
Heng Weng
Ziqing Liu
Shixing Yan
Meiyu Fan
Aihua Ou
Dacan Chen
Tianyong Hao
Copyright-Jahr
2017
DOI
https://doi.org/10.1007/978-3-319-69182-4_18