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Erschienen in:
Two-Scale Moving Boundary Dynamics of Cancer Invasion: Heterotypic Cell Populations’ Evolution in Heterogeneous ECM Kapitel lesen Erstes Kapitel lesen

2018 | OriginalPaper | Buchkapitel

A Multiscale Model of Cell Migration in Three-Dimensional Extracellular Matrix

verfasst von : Xiuxiu He, Yi Jiang

Erschienen in: Cell Movement

Verlag: Springer International Publishing

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Abstract

Cell migration in a three-dimensional (3D) extracellular matrix (ECM) is one of the key biological processes. Yet many fundamental questions remain unanswered. In this chapter, we introduce a modeling framework for a 3D, element-based, multiscale cell migration model. This model takes into account the mechanosensing signaling pathway, cell morphological dynamics, and cell-ECM interactions. To integrate the mechanochemical dynamics, we developed an implicit integration method to calculate forces for the elements and a moving boundary reaction-diffusion solver. The model is partially tested for cell migration on a curved substrate. Further development is needed to couple the cell model with a mechanical ECM model. This model can be used to test hypotheses of cell-ECM interactions and cell migration in tissue environment.

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Vorheriges Kapitel The Role of Microenvironment in Regulation of Cell Infiltration in Glioblastoma
Nächstes Kapitel Bayesian Uncertainty Quantification for Particle-Based Simulation of Lipid Bilayer Membranes
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Metadaten
Titel
A Multiscale Model of Cell Migration in Three-Dimensional Extracellular Matrix
verfasst von
Xiuxiu He
Yi Jiang
Copyright-Jahr
2018
Buch
Cell Movement

Print ISBN: 978-3-319-96841-4

Electronic ISBN: 978-3-319-96842-1

Copyright-Jahr: 2018

DOI
https://doi.org/10.1007/978-3-319-96842-1_3

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