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Neural Processing Letters
Erschienen in: Neural Processing Letters 3/2014

01.06.2014

A Neuron Model Including Gene Expression: Bistability, Long-Term Memory, etc.

verfasst von: Vladimir P. Zhdanov

Erschienen in: Neural Processing Letters | Ausgabe 3/2014

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Abstract

Acquisition, consolidation and reconsolidation of long-term memories include changes in gene expression in neurons. The understanding of the corresponding mechanistic details is still far from complete even on the conceptual level. Here, the author proposes a generic kinetic model describing a global interplay between the function of membrane ion channels and gene expression, including gene transcription into mRNA and mRNA translation into protein. The model, based partly on the Hindmarsh–Rose neuron model for membrane voltage, implies feedbacks between these processes. Specifically, the gene transcription is considered to depend on membrane voltage due to the corresponding dependence of one of the transcription factors. The number or efficiency of function of ion channels is in turn assumed to depend on the protein population. With these feedbacks, the model predicts either a single steady state or bistability. The bistable regimes are briefly discussed in the context of long-term memory.
Vorheriger Artikel The Kernel Recursive Least Squares CMAC with Vector Eligibility
Nächster Artikel Boundedness and Convergence of Split-Complex Back-Propagation Algorithm with Momentum and Penalty

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Metadaten
Titel
A Neuron Model Including Gene Expression: Bistability, Long-Term Memory, etc.
verfasst von
Vladimir P. Zhdanov
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Neural Processing Letters / Ausgabe 3/2014
Print ISSN: 1370-4621
Elektronische ISSN: 1573-773X
DOI
https://doi.org/10.1007/s11063-013-9304-y

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