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Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 2/2019

07.01.2019 | Original Contribution

A novel stimulus-responsive temozolomide supramolecular vesicle based on host–guest recognition

verfasst von: Mingfang Ma, Lingdong Kong, Zhongyu Du, Zengyang Xie, Lin Chen, Ruijiao Chen, Zhenquan Li, Jun Liu, Zhaolou Li, Aiyou Hao

Erschienen in: Colloid and Polymer Science | Ausgabe 2/2019

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Abstract

Temozolomide is a potent chemotherapeutic agent for glioblastoma multiforme treatment. However, its low aqueous solubility and short half-life (only about 1.8 h) in plasm limit its clinical therapeutics. Herein, a supramolecular vesicle based on hydroxypropyl-β-cyclodextrin and temozolomide was firstly constructed by elaborate design and preparation, which can load temozolomide into membranous layer of vesicle effectively. The morphologies and diameters of this temozolomide-loaded vesicle were characterized through transmission electron microscope, scanning electron microscope, and dynamic light scattering. The possible vesicle formation mechanism was further studied by X-ray diffraction, Fourier transform infrared spectrum, ultraviolet-visible spectroscopy, 1H nuclear magnetic resonance, and 2D nuclear magnetic resonance (ROSEY). Finally, the stimulus responsiveness of this vesicle was studied. Temozolomide can be released from the membrane of the vesicle once copper ions were dropped into the vesicle solution.
Vorheriger Artikel Polyethylene glycol–modified molybdenum oxide as NIR photothermal agent and its ablation ability for HeLa cells
Nächster Artikel A reverse lyotropic liquid crystal formed by cetylpyridiniumchloride in cyclohexane with the assistance of aromatic counterions

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Metadaten
Titel
A novel stimulus-responsive temozolomide supramolecular vesicle based on host–guest recognition
verfasst von
Mingfang Ma
Lingdong Kong
Zhongyu Du
Zengyang Xie
Lin Chen
Ruijiao Chen
Zhenquan Li
Jun Liu
Zhaolou Li
Aiyou Hao
Publikationsdatum
07.01.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Colloid and Polymer Science / Ausgabe 2/2019
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-018-04461-7

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