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Erschienen in:
2010 | OriginalPaper | Buchkapitel
A Simple Measure of the Dynamics of Segmented Genomes: An Application to Influenza
verfasst von : Stéphane Aris-Brosou
Erschienen in: Comparative Genomics
Verlag: Springer Berlin Heidelberg
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The severity of influenza epidemics, which can potentially become a pandemic, has been very difficult to predict. However, past efforts were focusing on gene-by-gene approaches, while it is acknowledged that the whole genome dynamics contribute to the severity of an epidemic. Here, putting this rationale into action, I describe a simple measure of the amount of reassortment that affects influenza at a genomic scale during a particular year. The analysis of 530 complete genomes of the H1N1 subtype, sampled over eleven years, shows that the proposed measure explains 58% of the variance in the prevalence of H1 influenza in the US population. The proposed measure, denoted
nRF
, could therefore improve influenza surveillance programs at a minimal cost.