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Erschienen in: Journal of Applied Mathematics and Computing 1-2/2012

01.10.2012 | Original Research

A two-strain epidemic model with mutant strain and vaccination

verfasst von: Liming Cai, Jingjing Xiang, Xuezhi Li, Abid Ali Lashari

Erschienen in: Journal of Applied Mathematics and Computing | Ausgabe 1-2/2012

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Abstract

In this paper, it is assumed that the spread of a pathogen can mutate in the host to create a second, cocirculating, mutant strain. Vaccinated individuals perhaps becomes infected after being in contact with individuals infected with mutant strain. A two-strain epidemic model with vaccination is firstly investigated. The existence and stability properties of equilibria in this model are examined. By analyzing the characteristic equation and constructing Lyapunov functions, the conditions for local and global stability of the infection-free, boundary and endemic equilibria are established. The existence of Hopf bifurcation from the endemic equilibrium is also examined as this equilibrium loses its stability. Our theoretical results are confirmed by numerical simulations.

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Literatur
1.
Zurück zum Zitat May, R., Norwak, M.: Coinfection and the evolution of parasite virulence. Proc. R. Soc. Lond. B, Biol. Sci. 261, 209–215 (1995) CrossRef May, R., Norwak, M.: Coinfection and the evolution of parasite virulence. Proc. R. Soc. Lond. B, Biol. Sci. 261, 209–215 (1995) CrossRef
2.
Zurück zum Zitat van Baalen, M., Sabelis, M.W.: The dynamics of multiple infection and the evolution of virulence. Am. Nat. 146, 881–910 (1995) CrossRef van Baalen, M., Sabelis, M.W.: The dynamics of multiple infection and the evolution of virulence. Am. Nat. 146, 881–910 (1995) CrossRef
3.
Zurück zum Zitat Parton, R., Hall, E., Wardlaw, A.C.: Responses to Bordetela pertussis mutant strains and to vaccination in the coughing rat model of pertussis. J. Med. Microbiol. 40, 307–312 (1994) CrossRef Parton, R., Hall, E., Wardlaw, A.C.: Responses to Bordetela pertussis mutant strains and to vaccination in the coughing rat model of pertussis. J. Med. Microbiol. 40, 307–312 (1994) CrossRef
4.
Zurück zum Zitat Bonhoeffer, S., Nowak, M.: Mutation and the evolution of virulence. Proc. R. Soc. Lond. B, Biol. Sci. 258, 133–140 (1994) CrossRef Bonhoeffer, S., Nowak, M.: Mutation and the evolution of virulence. Proc. R. Soc. Lond. B, Biol. Sci. 258, 133–140 (1994) CrossRef
5.
Zurück zum Zitat Earn, D.J.D., Dushoff, J., Levin, S.A.: Ecology and evolution of the flu. Trends Ecol. Evol. 17, 334–340 (2002) CrossRef Earn, D.J.D., Dushoff, J., Levin, S.A.: Ecology and evolution of the flu. Trends Ecol. Evol. 17, 334–340 (2002) CrossRef
7.
Zurück zum Zitat Ackleh, A., Allen, L.: Competitive exclusion and coexistence for pathogens in an epidemic model with variable population size. J. Math. Biol. 47, 153–168 (2003) MathSciNetMATHCrossRef Ackleh, A., Allen, L.: Competitive exclusion and coexistence for pathogens in an epidemic model with variable population size. J. Math. Biol. 47, 153–168 (2003) MathSciNetMATHCrossRef
8.
Zurück zum Zitat Bremermann, H.J., Thieme, H.R.: A competitive exclusion principle for pathogen virulence. J. Math. Biol. 27, 179–190 (1989) MathSciNetMATHCrossRef Bremermann, H.J., Thieme, H.R.: A competitive exclusion principle for pathogen virulence. J. Math. Biol. 27, 179–190 (1989) MathSciNetMATHCrossRef
9.
Zurück zum Zitat Lu, Z., Zhou, Y.: Advance in Mathematic Biology. China Science Press, Beijing (2006) Lu, Z., Zhou, Y.: Advance in Mathematic Biology. China Science Press, Beijing (2006)
10.
11.
Zurück zum Zitat Iannelli, M., Martcheva, M., Li, X.: Strain replacement in an epidemic model with super-infection and perfect vaccination. Math. Biosci. 195, 23–46 (2005) MathSciNetMATHCrossRef Iannelli, M., Martcheva, M., Li, X.: Strain replacement in an epidemic model with super-infection and perfect vaccination. Math. Biosci. 195, 23–46 (2005) MathSciNetMATHCrossRef
12.
Zurück zum Zitat Cai, L., Li, X., Yu, J.: A two-strain epidemic model with super-infection and vaccination. Math. Appl. 20, 328–335 (2007) MathSciNetMATH Cai, L., Li, X., Yu, J.: A two-strain epidemic model with super-infection and vaccination. Math. Appl. 20, 328–335 (2007) MathSciNetMATH
13.
Zurück zum Zitat Martcheva, M., Bolker, B.M., Holt, R.D.: Vaccine-induced pathogen strain replacement: what are the mechanisms? J. R. Soc. Interface 5, 3–13 (2008) CrossRef Martcheva, M., Bolker, B.M., Holt, R.D.: Vaccine-induced pathogen strain replacement: what are the mechanisms? J. R. Soc. Interface 5, 3–13 (2008) CrossRef
14.
Zurück zum Zitat May, R., Nowak, M.: Coinfection and the evolution of parasite virulence. Proc. R. Soc. Lond. B, Biol. Sci. 261, 209–215 (1995) CrossRef May, R., Nowak, M.: Coinfection and the evolution of parasite virulence. Proc. R. Soc. Lond. B, Biol. Sci. 261, 209–215 (1995) CrossRef
15.
Zurück zum Zitat Martcheva, M., Iannelli, M., Li, X.: Subthreshold coexistence of strains: the impact of vaccination mutation. Math. Biosci. Eng. 7(3), 689–719 (2010) Martcheva, M., Iannelli, M., Li, X.: Subthreshold coexistence of strains: the impact of vaccination mutation. Math. Biosci. Eng. 7(3), 689–719 (2010)
16.
Zurück zum Zitat Castillo-Chavez, C., Blower, S., van den Driessche, P., Kirschner, D., Yakubu, A.A.: Mathematical Approaches for Emerging and Reemerging Infectious Diseases: Models, Methods, and Theory. Springer, New York (2002) CrossRef Castillo-Chavez, C., Blower, S., van den Driessche, P., Kirschner, D., Yakubu, A.A.: Mathematical Approaches for Emerging and Reemerging Infectious Diseases: Models, Methods, and Theory. Springer, New York (2002) CrossRef
18.
Zurück zum Zitat Scherer, A., McLean, A.: Mathematical models of vaccination. Br. Med. Bull. 62, 187–199 (2002) CrossRef Scherer, A., McLean, A.: Mathematical models of vaccination. Br. Med. Bull. 62, 187–199 (2002) CrossRef
19.
Zurück zum Zitat Zhang, X., Huo, H., Sun, X., Fu, Q.: The differential susceptibility SIR epidemic model with time delay and pulse vaccination. J. Appl. Math. Comput. 34, 287–298 (2010) MathSciNetMATHCrossRef Zhang, X., Huo, H., Sun, X., Fu, Q.: The differential susceptibility SIR epidemic model with time delay and pulse vaccination. J. Appl. Math. Comput. 34, 287–298 (2010) MathSciNetMATHCrossRef
20.
Zurück zum Zitat Zhao, Z., Chen, L., Song, X.: Impulsive vaccination of SEIR epidemic model with time delay and nonlinear incidence rate. Math. Comput. Simul. 79(3), 500–510 (2008) MathSciNetMATHCrossRef Zhao, Z., Chen, L., Song, X.: Impulsive vaccination of SEIR epidemic model with time delay and nonlinear incidence rate. Math. Comput. Simul. 79(3), 500–510 (2008) MathSciNetMATHCrossRef
21.
Zurück zum Zitat Scherer, A., McLean, A.: Mathematical models of vaccination. Br. Med. Bull. 62(1), 187–199 (2002) CrossRef Scherer, A., McLean, A.: Mathematical models of vaccination. Br. Med. Bull. 62(1), 187–199 (2002) CrossRef
22.
Zurück zum Zitat Sansonetti, P.J., Arondel, J.: Construction and evaluation of a double mutant of Shigella flexneri as a candidate for oral vaccination against shigellosis. Vaccine 7(5), 443–450 (1989) CrossRef Sansonetti, P.J., Arondel, J.: Construction and evaluation of a double mutant of Shigella flexneri as a candidate for oral vaccination against shigellosis. Vaccine 7(5), 443–450 (1989) CrossRef
24.
Metadaten
Titel
A two-strain epidemic model with mutant strain and vaccination
verfasst von
Liming Cai
Jingjing Xiang
Xuezhi Li
Abid Ali Lashari
Publikationsdatum
01.10.2012
Verlag
Springer-Verlag
Erschienen in
Journal of Applied Mathematics and Computing / Ausgabe 1-2/2012
Print ISSN: 1598-5865
Elektronische ISSN: 1865-2085
DOI
https://doi.org/10.1007/s12190-012-0580-x

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