Skip to main content
Erschienen in: The Journal of Supercomputing 8/2021

25.01.2021

Adoption value of deep learning and serological indicators in the screening of atrophic gastritis based on artificial intelligence

verfasst von: Jianhai Zhang, Jianhong Yu, Suna Fu, Xinhua Tian

Erschienen in: The Journal of Supercomputing | Ausgabe 8/2021

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

This work aimed to improve the early clinical diagnosis rate of atrophic gastritis (AG) and reduce the risk of disease deterioration or cancerization. Three hundred and eight patients with gastric disease were taken as the research object, who were divided into two groups: AG (n = 159) and non-AG (n = 149), according to the diagnosis results. The gastric antrum images of patients were collected, and the DenseNet model for gastric antrum image lesion screening was improved. Then, the differences in serum pepsinogen (PG I and PG II) of patients were detected, and the efficiency of different methods to screen AG was compared. The results revealed that the levels of PG I and PG II in AG patients were substantially reduced, and the sensitivity (70.44%), specificity (66.44%), and accuracy (68.51%) of AG diagnosis by indicator PG I were higher than that of PG II and joint diagnosis. The diagnosis accuracy rate of AG based on the improved DenseNet model was 98.63%. The accuracy of model recognition combined with serological indicators for disease diagnosis was as high as 99.25%, with a sensitivity of 96.17% and a specificity of 94.33%. In summary, the combination of deep learning-based image recognition methods and serological specific indicators could improve the clinical diagnosis rate of AG, which could provide a reference for the subsequent clinical adoption of artificial intelligence recognition technology.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Yao F, Shi CL, Liu CC et al (2017) Economic burden of stomach cancer in China during 1996–2015: a systematic review. Zhonghua Yu Fang Yi Xue Za Zhi 51(8):756–762 Yao F, Shi CL, Liu CC et al (2017) Economic burden of stomach cancer in China during 1996–2015: a systematic review. Zhonghua Yu Fang Yi Xue Za Zhi 51(8):756–762
2.
Zurück zum Zitat Venneman K, Huybrechts I, Gunter MJ et al (2018) The epidemiology of Helicobacter pylori infection in Europe and the impact of lifestyle on its natural evolution toward stomach cancer after infection: a systematic review. Helicobacter 23(3):e12483CrossRef Venneman K, Huybrechts I, Gunter MJ et al (2018) The epidemiology of Helicobacter pylori infection in Europe and the impact of lifestyle on its natural evolution toward stomach cancer after infection: a systematic review. Helicobacter 23(3):e12483CrossRef
3.
Zurück zum Zitat Li Y, Xia R, Zhang B, Li C (2018) Chronic atrophic gastritis: a review. J Environ Pathol Toxicol Oncol 37(3):241–259CrossRef Li Y, Xia R, Zhang B, Li C (2018) Chronic atrophic gastritis: a review. J Environ Pathol Toxicol Oncol 37(3):241–259CrossRef
4.
Zurück zum Zitat Rodriguez-Castro KI, Franceschi M, Miraglia C et al (2018) Autoimmune diseases in autoimmune atrophic gastritis. Acta Biomed 89(8):100–103 Rodriguez-Castro KI, Franceschi M, Miraglia C et al (2018) Autoimmune diseases in autoimmune atrophic gastritis. Acta Biomed 89(8):100–103
5.
Zurück zum Zitat Tahara S, Tahara T, Horiguchi N et al (2019) DNA methylation accumulation in gastric mucosa adjacent to cancer after Helicobacter pylori eradication. Int J Cancer 144(1):80–88CrossRef Tahara S, Tahara T, Horiguchi N et al (2019) DNA methylation accumulation in gastric mucosa adjacent to cancer after Helicobacter pylori eradication. Int J Cancer 144(1):80–88CrossRef
6.
Zurück zum Zitat Xuan Y, Hur H, Byun CS et al (2013) Efficacy of intraoperative gastroscopy for tumor localization in totally laparoscopic distal gastrectomy for cancer in the middle third of the stomach. Surg Endosc 27(11):4364–4370CrossRef Xuan Y, Hur H, Byun CS et al (2013) Efficacy of intraoperative gastroscopy for tumor localization in totally laparoscopic distal gastrectomy for cancer in the middle third of the stomach. Surg Endosc 27(11):4364–4370CrossRef
7.
Zurück zum Zitat Thillaikkarasi R, Saravanan S (2019) An enhancement of deep learning algorithm for brain tumor segmentation using kernel based CNN with M-SVM. J Med Syst 43(4):84CrossRef Thillaikkarasi R, Saravanan S (2019) An enhancement of deep learning algorithm for brain tumor segmentation using kernel based CNN with M-SVM. J Med Syst 43(4):84CrossRef
8.
Zurück zum Zitat Hussain S, Anwar SM, Majid M (2017) Brain tumor segmentation using cascaded deep convolutional neural network. Annu Int Conf IEEE Eng Med Biol Soc 2017:1998–2001 Hussain S, Anwar SM, Majid M (2017) Brain tumor segmentation using cascaded deep convolutional neural network. Annu Int Conf IEEE Eng Med Biol Soc 2017:1998–2001
9.
Zurück zum Zitat Yamaguchi Y, Nagata Y, Hiratsuka R et al (2016) Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels-the ABC method. Digestion 93(1):13–18CrossRef Yamaguchi Y, Nagata Y, Hiratsuka R et al (2016) Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels-the ABC method. Digestion 93(1):13–18CrossRef
10.
Zurück zum Zitat Leja M, Park JY, Murillo R et al (2017) Multicentric randomised study of Helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality: the GISTAR study. BMJ Open 7(8):e016999CrossRef Leja M, Park JY, Murillo R et al (2017) Multicentric randomised study of Helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality: the GISTAR study. BMJ Open 7(8):e016999CrossRef
11.
Zurück zum Zitat Begum A, Baten MA, Begum Z et al (2017) Role of serum pepsinogen I and II ratio in screening of gastric carcinoma. Mymensingh Med J 26(3):628–634 Begum A, Baten MA, Begum Z et al (2017) Role of serum pepsinogen I and II ratio in screening of gastric carcinoma. Mymensingh Med J 26(3):628–634
12.
Zurück zum Zitat Yoon K, Kim N (2018) Reversibility of atrophic gastritis and intestinal metaplasia by eradication of Helicobacter pylori. Korean J Gastroenterol 72(3):104–115CrossRef Yoon K, Kim N (2018) Reversibility of atrophic gastritis and intestinal metaplasia by eradication of Helicobacter pylori. Korean J Gastroenterol 72(3):104–115CrossRef
13.
Zurück zum Zitat Jin EH, Chung SJ, Lim JH (2018) Training effect on the inter-observer agreement in endoscopic diagnosis and grading of atrophic gastritis according to level of endoscopic experience. J Korean Med Sci 33(15):e117CrossRef Jin EH, Chung SJ, Lim JH (2018) Training effect on the inter-observer agreement in endoscopic diagnosis and grading of atrophic gastritis according to level of endoscopic experience. J Korean Med Sci 33(15):e117CrossRef
14.
Zurück zum Zitat Chapelle N, Petryszyn P, Blin J, Leroy M, Tamara Matysiak〣udnik (2020) A panel of stomach: specific biomarkers (gastropanel) for the diagnosis of atrophic gastritis: a prospective, multicenter study in a low gastric cancer incidence area. Helicobacter 25(5):2020CrossRef Chapelle N, Petryszyn P, Blin J, Leroy M, Tamara Matysiak〣udnik (2020) A panel of stomach: specific biomarkers (gastropanel) for the diagnosis of atrophic gastritis: a prospective, multicenter study in a low gastric cancer incidence area. Helicobacter 25(5):2020CrossRef
15.
Zurück zum Zitat Zagari RM, Rabitti S, Greenwood DC et al (2017) Systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-Helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis. Aliment Pharmacol Ther 46(7):657–667CrossRef Zagari RM, Rabitti S, Greenwood DC et al (2017) Systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-Helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis. Aliment Pharmacol Ther 46(7):657–667CrossRef
16.
Zurück zum Zitat Tong Y, Wu Y, Song Z et al (2017) The potential value of serum pepsinogen for the diagnosis of atrophic gastritis among the health check-up populations in China: a diagnostic clinical research. BMC Gastroenterol 17(1):88CrossRef Tong Y, Wu Y, Song Z et al (2017) The potential value of serum pepsinogen for the diagnosis of atrophic gastritis among the health check-up populations in China: a diagnostic clinical research. BMC Gastroenterol 17(1):88CrossRef
17.
Zurück zum Zitat Cavalcoli F, Zilli A, Conte D, Massironi S (2017) Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review. World J Gastroenterol 23(4):563–572CrossRef Cavalcoli F, Zilli A, Conte D, Massironi S (2017) Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review. World J Gastroenterol 23(4):563–572CrossRef
18.
Zurück zum Zitat PérezRomero S, Alberca de Las Parras F, SánchezDelRío A et al (2019) Quality indicators in gastroscopy. Gastroscopy procedure. Rev Esp Enferm Dig 111(9):699–709 PérezRomero S, Alberca de Las Parras F, SánchezDelRío A et al (2019) Quality indicators in gastroscopy. Gastroscopy procedure. Rev Esp Enferm Dig 111(9):699–709
19.
Zurück zum Zitat Nishihara K, Oono Y, Kuwata T et al (2019) Depressed gastric-type adenoma in nonatrophic gastric mucosa without Helicobacter pylori infection. Endoscopy 51(6):E138–E140CrossRef Nishihara K, Oono Y, Kuwata T et al (2019) Depressed gastric-type adenoma in nonatrophic gastric mucosa without Helicobacter pylori infection. Endoscopy 51(6):E138–E140CrossRef
20.
Zurück zum Zitat Grewal PS, Oloumi F, Rubin U, Tennant MTS (2018) Deep learning in ophthalmology: a review. Can J Ophthalmol 53(4):309–313CrossRef Grewal PS, Oloumi F, Rubin U, Tennant MTS (2018) Deep learning in ophthalmology: a review. Can J Ophthalmol 53(4):309–313CrossRef
21.
Zurück zum Zitat Litjens G, Ciompi F, Wolterink JM et al (2019) State-of-the-art deep learning in cardiovascular image analysis. JACC Cardiovasc Imaging 12(8 Pt 1):1549–1565CrossRef Litjens G, Ciompi F, Wolterink JM et al (2019) State-of-the-art deep learning in cardiovascular image analysis. JACC Cardiovasc Imaging 12(8 Pt 1):1549–1565CrossRef
22.
Zurück zum Zitat Kumar M, Alshehri M, Alghamdi R, Sharma P, Deep V (2020) A de-ann inspired skin cancer detection approach using fuzzy c-means clustering. Mobile Netw Appl 25:1319–1329CrossRef Kumar M, Alshehri M, Alghamdi R, Sharma P, Deep V (2020) A de-ann inspired skin cancer detection approach using fuzzy c-means clustering. Mobile Netw Appl 25:1319–1329CrossRef
23.
Zurück zum Zitat Wang S, Yang DM, Rong R, Zhan X, Xiao G (2019) Pathology image analysis using segmentation deep learning algorithms. Am J Pathol 189(9):1686–1698CrossRef Wang S, Yang DM, Rong R, Zhan X, Xiao G (2019) Pathology image analysis using segmentation deep learning algorithms. Am J Pathol 189(9):1686–1698CrossRef
24.
Zurück zum Zitat Sahiner B, Pezeshk A, Hadjiiski LM et al (2019) Deep learning in medical imaging and radiation therapy. Med Phys 46(1):e1–e36CrossRef Sahiner B, Pezeshk A, Hadjiiski LM et al (2019) Deep learning in medical imaging and radiation therapy. Med Phys 46(1):e1–e36CrossRef
25.
Zurück zum Zitat Xiao Y, Wu J, Lin Z, Zhao X (2018) A deep learning-based multi-model ensemble method for cancer prediction. Comput Methods Programs Biomed 153:1–9CrossRef Xiao Y, Wu J, Lin Z, Zhao X (2018) A deep learning-based multi-model ensemble method for cancer prediction. Comput Methods Programs Biomed 153:1–9CrossRef
26.
Zurück zum Zitat Al-Khafaji SL, Jun Z, Zia A, Liew AW (2018) Spectral-spatial scale invariant feature transform for hyperspectral images. IEEE Trans Image Process 27(2):837–850MathSciNetMATHCrossRef Al-Khafaji SL, Jun Z, Zia A, Liew AW (2018) Spectral-spatial scale invariant feature transform for hyperspectral images. IEEE Trans Image Process 27(2):837–850MathSciNetMATHCrossRef
27.
Zurück zum Zitat Zhou Q, Zhou Z, Chen C et al (2019) Grading of hepatocellular carcinoma using 3D SE-DenseNet in dynamic enhanced MR images. Comput Biol Med 107:47–57CrossRef Zhou Q, Zhou Z, Chen C et al (2019) Grading of hepatocellular carcinoma using 3D SE-DenseNet in dynamic enhanced MR images. Comput Biol Med 107:47–57CrossRef
28.
Zurück zum Zitat Su W, Zhou B, Qin G et al (2018) Low PG I/II ratio as a marker of atrophic gastritis: association with nutritional and metabolic status in healthy people. Medicine (Baltimore) 97(20):e10820CrossRef Su W, Zhou B, Qin G et al (2018) Low PG I/II ratio as a marker of atrophic gastritis: association with nutritional and metabolic status in healthy people. Medicine (Baltimore) 97(20):e10820CrossRef
29.
Zurück zum Zitat Mansour-Ghanaei F, Joukar F, Baghaee M, Sepehrimanesh M, Hojati A (2019) Only serum pepsinogen I and pepsinogen I/II ratio are specific and sensitive biomarkers for screening of gastric cancer. Biomol Concepts 10(1):82–90CrossRef Mansour-Ghanaei F, Joukar F, Baghaee M, Sepehrimanesh M, Hojati A (2019) Only serum pepsinogen I and pepsinogen I/II ratio are specific and sensitive biomarkers for screening of gastric cancer. Biomol Concepts 10(1):82–90CrossRef
30.
Zurück zum Zitat Mezmale L, Isajevs S, Bogdanova I et al (2019) Prevalence of atrophic gastritis in Kazakhstan and the accuracy of pepsinogen tests to detect gastric mucosal atrophy. Asian Pac J Cancer Prev 20(12):3825–3829CrossRef Mezmale L, Isajevs S, Bogdanova I et al (2019) Prevalence of atrophic gastritis in Kazakhstan and the accuracy of pepsinogen tests to detect gastric mucosal atrophy. Asian Pac J Cancer Prev 20(12):3825–3829CrossRef
31.
Zurück zum Zitat Massarrat S, Haj-Sheykholeslami A (2016) Increased serum pepsinogen II level as a marker of pangastritis and corpus-predominant gastritis in gastric cancer prevention. Arch Iran Med 19(2):137–140 Massarrat S, Haj-Sheykholeslami A (2016) Increased serum pepsinogen II level as a marker of pangastritis and corpus-predominant gastritis in gastric cancer prevention. Arch Iran Med 19(2):137–140
32.
Zurück zum Zitat Zagari RM, Rabitti S, Greenwood DC, Eusebi LH, Vestito A, Bazzoli F (2017) Systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-Helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis. Aliment Pharmacol Ther 46(7):657–667CrossRef Zagari RM, Rabitti S, Greenwood DC, Eusebi LH, Vestito A, Bazzoli F (2017) Systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-Helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis. Aliment Pharmacol Ther 46(7):657–667CrossRef
33.
Zurück zum Zitat Shao X, Zhang H, Wang Y et al (2020) Deep convolutional neural networks combine Raman spectral signature of serum for prostate cancer bone metastases screening. Nanomedicine 29:102245CrossRef Shao X, Zhang H, Wang Y et al (2020) Deep convolutional neural networks combine Raman spectral signature of serum for prostate cancer bone metastases screening. Nanomedicine 29:102245CrossRef
34.
Zurück zum Zitat Guan Q, Wang Y, Ping B et al (2019) Deep convolutional neural network VGG-16 model for differential diagnosing of papillary thyroid carcinomas in cytological images: a pilot study. J Cancer 10(20):4876–4882CrossRef Guan Q, Wang Y, Ping B et al (2019) Deep convolutional neural network VGG-16 model for differential diagnosing of papillary thyroid carcinomas in cytological images: a pilot study. J Cancer 10(20):4876–4882CrossRef
35.
Zurück zum Zitat Dawud AM, Yurtkan K, Oztoprak H (2019) Application of deep learning in neuroradiology: brain haemorrhage classification using transfer learning. Comput Intell Neurosci 2019:4629859CrossRef Dawud AM, Yurtkan K, Oztoprak H (2019) Application of deep learning in neuroradiology: brain haemorrhage classification using transfer learning. Comput Intell Neurosci 2019:4629859CrossRef
36.
Zurück zum Zitat Ding Y, Sohn JH, Kawczynski MG et al (2019) A deep learning model to predict a diagnosis of Alzheimer disease by using 18F-FDG PET of the brain. Radiology 290(2):456–464CrossRef Ding Y, Sohn JH, Kawczynski MG et al (2019) A deep learning model to predict a diagnosis of Alzheimer disease by using 18F-FDG PET of the brain. Radiology 290(2):456–464CrossRef
37.
Zurück zum Zitat Brito C, Machado A, Sousa A (2019) Electrocardiogram beat-classification based on a ResNet network. Stud Health Technol Inform 264:55–59 Brito C, Machado A, Sousa A (2019) Electrocardiogram beat-classification based on a ResNet network. Stud Health Technol Inform 264:55–59
38.
Zurück zum Zitat Cai J, Xing F, Batra A et al (2019) Texture analysis for muscular dystrophy classification in MRI with improved class activation mapping. Pattern Recognit 86:368–375CrossRef Cai J, Xing F, Batra A et al (2019) Texture analysis for muscular dystrophy classification in MRI with improved class activation mapping. Pattern Recognit 86:368–375CrossRef
Metadaten
Titel
Adoption value of deep learning and serological indicators in the screening of atrophic gastritis based on artificial intelligence
verfasst von
Jianhai Zhang
Jianhong Yu
Suna Fu
Xinhua Tian
Publikationsdatum
25.01.2021
Verlag
Springer US
Erschienen in
The Journal of Supercomputing / Ausgabe 8/2021
Print ISSN: 0920-8542
Elektronische ISSN: 1573-0484
DOI
https://doi.org/10.1007/s11227-021-03630-w

Weitere Artikel der Ausgabe 8/2021

The Journal of Supercomputing 8/2021 Zur Ausgabe