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Erschienen in:
X-Ray Free Electron Lasers and Their Applications Kapitel lesen Erstes Kapitel lesen

2018 | OriginalPaper | Buchkapitel

10. Advances in Structure Determination of G Protein-Coupled Receptors by SFX

verfasst von : Benjamin Stauch, Linda Johansson, Andrii Ishchenko, Gye Won Han, Alexander Batyuk, Vadim Cherezov

Erschienen in: X-ray Free Electron Lasers

Verlag: Springer International Publishing

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Abstract

G protein-coupled receptors (GPCRs) constitute the largest superfamily of membrane proteins, members of which are involved in regulation of critical sensory and physiological processes in the human body. High-resolution GPCR structures are essential for the elucidation of the molecular mechanisms of signal transduction, and for the rational design of more effective therapeutics. GPCR structure determination is, however, hampered by challenges in their expression, stabilization, and crystallization. The recent emergence of X-ray free electron lasers (FELs), and establishment of serial femtosecond crystallography (SFX) have advanced the field of structural biology by enabling access to high-resolution structure and dynamics of challenging to crystallize and radiation damage-sensitive macromolecules. In this chapter we outline relevant SFX technology developments and its applications to structural studies of GPCRs, shedding light on ligand binding to antitumor and anti-addiction targets, uncovering molecular mechanisms behind distinct functions of angiotensin receptors, elucidating full-length structures of multidomain class B and Frizzled receptors, and revealing details of interactions between GPCRs and arrestins.

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Vorheriges Kapitel Structure Determination by Continuous Diffraction from Imperfect Crystals
Nächstes Kapitel Time-Resolved Serial Femtosecond Crystallography, Towards Molecular Movies of Biomolecules in Action
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Metadaten
Titel
Advances in Structure Determination of G Protein-Coupled Receptors by SFX
verfasst von
Benjamin Stauch
Linda Johansson
Andrii Ishchenko
Gye Won Han
Alexander Batyuk
Vadim Cherezov
Copyright-Jahr
2018
Buch
X-ray Free Electron Lasers

Print ISBN: 978-3-030-00550-4

Electronic ISBN: 978-3-030-00551-1

Copyright-Jahr: 2018

DOI
https://doi.org/10.1007/978-3-030-00551-1_10

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