Skip to main content
Erschienen in:
Buchtitelbild

2019 | OriginalPaper | Buchkapitel

1. Advances of Single-Cell Analysis on Microfluidics

verfasst von : Qiushi Huang, Jin-Ming Lin

Erschienen in: Microfluidics for Single-Cell Analysis

Verlag: Springer Singapore

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

The advances of microfluidic technologies have promoted researchers to study the inherent heterogeneity of single cells in cell populations. This will be helpful in the acknowledgment of major disease and invention of personalized medicine. Different microfluidic approaches provide varieties of functions in the process of single-cell analysis. In this chapter, we introduce decades of the history in single-cell analysis and give an outline of the mechanisms of various microfluidic-based approaches for cell sorting, single-cell isolation, and single-cell lysis.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literatur
2.
Zurück zum Zitat Fiering S, Northrop JP, Nolan GP, Mattila PS, Crabtree GR, Herzenberg LA (1990) Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. Genes Dev 4(10):1823–1834CrossRef Fiering S, Northrop JP, Nolan GP, Mattila PS, Crabtree GR, Herzenberg LA (1990) Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. Genes Dev 4(10):1823–1834CrossRef
4.
Zurück zum Zitat Dexter DL, Kowalski HM, Blazar BA, Fligiel Z, Vogel R, Heppner GH (1978) Heterogeneity of tumor cells from a single mouse mammary tumor. Cancer Res 38(10):3174–3181PubMed Dexter DL, Kowalski HM, Blazar BA, Fligiel Z, Vogel R, Heppner GH (1978) Heterogeneity of tumor cells from a single mouse mammary tumor. Cancer Res 38(10):3174–3181PubMed
11.
Zurück zum Zitat Mao S, Zhang W, Huang Q, Khan M, Li H, Uchiyama K, Lin JM (2018) In Situ scatheless cell detachment reveals correlation between adhesion strength and viability at single-cell resolution. Angew Chem Int Ed 57(1):236–240CrossRef Mao S, Zhang W, Huang Q, Khan M, Li H, Uchiyama K, Lin JM (2018) In Situ scatheless cell detachment reveals correlation between adhesion strength and viability at single-cell resolution. Angew Chem Int Ed 57(1):236–240CrossRef
12.
Zurück zum Zitat Lin L, Lin X, Lin L, Feng Q, Kitamori T, Lin JM, Sun J (2017) Integrated microfluidic platform with multiple functions to probe tumor–endothelial cell interaction. Anal Chem 89(18):10037–10044CrossRef Lin L, Lin X, Lin L, Feng Q, Kitamori T, Lin JM, Sun J (2017) Integrated microfluidic platform with multiple functions to probe tumor–endothelial cell interaction. Anal Chem 89(18):10037–10044CrossRef
14.
Zurück zum Zitat Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M (2008) Equilibrium separation and filtration of particles using differential inertial focusing. Anal Chem 80:2204–2211CrossRef Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M (2008) Equilibrium separation and filtration of particles using differential inertial focusing. Anal Chem 80:2204–2211CrossRef
15.
Zurück zum Zitat Wang XB, Yang J, Huang Y, Vykoukal J, Becker FF, Gascoyne PR (2000) Cell separation by dielectrophoretic field-flow-fractionation. Anal Chem 72:832–839CrossRef Wang XB, Yang J, Huang Y, Vykoukal J, Becker FF, Gascoyne PR (2000) Cell separation by dielectrophoretic field-flow-fractionation. Anal Chem 72:832–839CrossRef
17.
Zurück zum Zitat Matioli GT, Niewisch HB (1965) Electrophoresis of hemoglobin in single erythrocytes. Science 150(3705):1824–1826CrossRef Matioli GT, Niewisch HB (1965) Electrophoresis of hemoglobin in single erythrocytes. Science 150(3705):1824–1826CrossRef
18.
Zurück zum Zitat Osborne NN, Szczepaniak AC, Neuhoff V (1973) Amines and amino acids in identified neurons of Helix pomatia. Int J Neurosci 5(3):125–131CrossRef Osborne NN, Szczepaniak AC, Neuhoff V (1973) Amines and amino acids in identified neurons of Helix pomatia. Int J Neurosci 5(3):125–131CrossRef
19.
Zurück zum Zitat McADOO DJ (1978) The Retzius cell of the leech hirudo medicinalis. In: Osborne NN (ed) Biochemistry of Characterised Neurons. Elsevier, Amsterdam McADOO DJ (1978) The Retzius cell of the leech hirudo medicinalis. In: Osborne NN (ed) Biochemistry of Characterised Neurons. Elsevier, Amsterdam
21.
Zurück zum Zitat McCaman RE, Weinreich D, Borys H (1973) Endogenous levels of acetylcholine and choline in individual neurons of Aplysia. J Neurochem 21(2):473–476CrossRef McCaman RE, Weinreich D, Borys H (1973) Endogenous levels of acetylcholine and choline in individual neurons of Aplysia. J Neurochem 21(2):473–476CrossRef
22.
Zurück zum Zitat Melamed MR, Lindmo T, Mendelsohn ML, Bigler RD (1991) Flow cytometry and sorting. Am J Clin Oncol 14(1):90CrossRef Melamed MR, Lindmo T, Mendelsohn ML, Bigler RD (1991) Flow cytometry and sorting. Am J Clin Oncol 14(1):90CrossRef
23.
Zurück zum Zitat Neher E, Sakmann B (1976) Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature 260(5554):799–802CrossRef Neher E, Sakmann B (1976) Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature 260(5554):799–802CrossRef
24.
Zurück zum Zitat Kennedy RT, Stclaire RL, White JG, Jorgenson JW (1987) Chemical-analysis of single neurons by open tubular liquid-chromatography. Mikrochim Acta 2(1–3):37–45CrossRef Kennedy RT, Stclaire RL, White JG, Jorgenson JW (1987) Chemical-analysis of single neurons by open tubular liquid-chromatography. Mikrochim Acta 2(1–3):37–45CrossRef
30.
Zurück zum Zitat Zhang Z, Krylov S, Arriaga EA, Polakowski R, Dovichi NJ (2000) One-dimensional protein analysis of an HT29 human colon adenocarcinoma cell. Anal Chem 72(2):318–322CrossRef Zhang Z, Krylov S, Arriaga EA, Polakowski R, Dovichi NJ (2000) One-dimensional protein analysis of an HT29 human colon adenocarcinoma cell. Anal Chem 72(2):318–322CrossRef
31.
Zurück zum Zitat Hu S, Le Z, Newitt R, Aebersold R, Kraly JR, Jones M, Dovichi NJ (2003) Identification of proteins in single-cell capillary electrophoresis fingerprints based on comigration with standard proteins. Anal Chem 75(14):3502–3505CrossRef Hu S, Le Z, Newitt R, Aebersold R, Kraly JR, Jones M, Dovichi NJ (2003) Identification of proteins in single-cell capillary electrophoresis fingerprints based on comigration with standard proteins. Anal Chem 75(14):3502–3505CrossRef
32.
Zurück zum Zitat Zhu G, Sun L, Yan X, Dovichi NJ (2013) Single-shot proteomics using capillary zone electrophoresis–electrospray ionization-tandem mass spectrometry with production of more than 1 250 Escherichia coli peptide identifications in a 50 min separation. Anal Chem 85:2569–2573CrossRef Zhu G, Sun L, Yan X, Dovichi NJ (2013) Single-shot proteomics using capillary zone electrophoresis–electrospray ionization-tandem mass spectrometry with production of more than 1 250 Escherichia coli peptide identifications in a 50 min separation. Anal Chem 85:2569–2573CrossRef
35.
Zurück zum Zitat Armbrecht L, Dittrich PS (2017) Recent advances in the analysis of single cells. Anal Chem 89(1):2–21CrossRef Armbrecht L, Dittrich PS (2017) Recent advances in the analysis of single cells. Anal Chem 89(1):2–21CrossRef
40.
Zurück zum Zitat Wheeler AR, Throndset WR, Whelan RJ, Leach AM, Zare RN, Liao YH, Farrell K, Manger ID, Daridon A (2003) Microfluidic device for single-cell analysis. Anal Chem 75(14):3581–3586CrossRef Wheeler AR, Throndset WR, Whelan RJ, Leach AM, Zare RN, Liao YH, Farrell K, Manger ID, Daridon A (2003) Microfluidic device for single-cell analysis. Anal Chem 75(14):3581–3586CrossRef
43.
Zurück zum Zitat Broyles BS, Jacobson SC, Ramsey JM (2003) Sample filtration, concentration, and separation integrated on microfluidic devices. Anal Chem 75(11):2761–2767CrossRef Broyles BS, Jacobson SC, Ramsey JM (2003) Sample filtration, concentration, and separation integrated on microfluidic devices. Anal Chem 75(11):2761–2767CrossRef
44.
Zurück zum Zitat Liu C, Liu J, Gao D, Ding M, Lin J-M (2010) Fabrication of microwell arrays based on two-dimensional ordered polystyrene microspheres for high-throughput single-cell analysis. Anal Chem 82(22):9418–9424CrossRef Liu C, Liu J, Gao D, Ding M, Lin J-M (2010) Fabrication of microwell arrays based on two-dimensional ordered polystyrene microspheres for high-throughput single-cell analysis. Anal Chem 82(22):9418–9424CrossRef
45.
Zurück zum Zitat Chen Q, Wu J, Zhang Y, Lin Z, Lin J-M (2012) Targeted isolation and analysis of single tumor cells with aptamer-encoded microwell array on microfluidic device. Lab Chip 12(24):5180–5185CrossRef Chen Q, Wu J, Zhang Y, Lin Z, Lin J-M (2012) Targeted isolation and analysis of single tumor cells with aptamer-encoded microwell array on microfluidic device. Lab Chip 12(24):5180–5185CrossRef
46.
Zurück zum Zitat Liu J, Gao D, Mao S, Lin J-M (2012) A microfluidic photolithography for controlled encapsulation of single cells inside hydrogel microstructures. Sci China Chem 55(4):494–501CrossRef Liu J, Gao D, Mao S, Lin J-M (2012) A microfluidic photolithography for controlled encapsulation of single cells inside hydrogel microstructures. Sci China Chem 55(4):494–501CrossRef
47.
Zurück zum Zitat Shields CW IV, Reyes CD, López GP (2015) Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation. Lab Chip 15(5):1230–1249CrossRef Shields CW IV, Reyes CD, López GP (2015) Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation. Lab Chip 15(5):1230–1249CrossRef
60.
Zurück zum Zitat Ashkin A, Dziedzic JM, Bjorkholm JE, Chu S (1986) Observation of a single-beam gradient force optical trap for dielectric particles. Opt Lett 11(5):288CrossRef Ashkin A, Dziedzic JM, Bjorkholm JE, Chu S (1986) Observation of a single-beam gradient force optical trap for dielectric particles. Opt Lett 11(5):288CrossRef
70.
Zurück zum Zitat Geislinger TM, Franke T (2014) Hydrodynamic lift of vesicles and red blood cells in flow—from Fåhræus & Lindqvist to microfluidic cell sorting. Adv Colloid Interfac 208:161–176CrossRef Geislinger TM, Franke T (2014) Hydrodynamic lift of vesicles and red blood cells in flow—from Fåhræus & Lindqvist to microfluidic cell sorting. Adv Colloid Interfac 208:161–176CrossRef
71.
Zurück zum Zitat Huang Q, Mao S, Khan M, Zhou Z, Lin J-M (2018) Dean flow assisted-cell ordering system for lipid profiling in single-cells using mass spectrometry. Chem Commun 54:2595–2598CrossRef Huang Q, Mao S, Khan M, Zhou Z, Lin J-M (2018) Dean flow assisted-cell ordering system for lipid profiling in single-cells using mass spectrometry. Chem Commun 54:2595–2598CrossRef
73.
Zurück zum Zitat Unger MA, Chou HP, Thorsen T, Scherer A, Quake SR (2000) Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288(5463):113–116CrossRef Unger MA, Chou HP, Thorsen T, Scherer A, Quake SR (2000) Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288(5463):113–116CrossRef
75.
Zurück zum Zitat Kim S-H, Lee GH, Park JY (2013) Microwell fabrication methods and applications for cellular studies. Biomed Eng Lett 3(3):131–137CrossRef Kim S-H, Lee GH, Park JY (2013) Microwell fabrication methods and applications for cellular studies. Biomed Eng Lett 3(3):131–137CrossRef
76.
Zurück zum Zitat Lindström S, Andersson-Svahn A (2011) Miniaturization of biological assays—overview on microwell devices for single-cell analyses. BBA-Gen Subjects 1810(3):308–316CrossRef Lindström S, Andersson-Svahn A (2011) Miniaturization of biological assays—overview on microwell devices for single-cell analyses. BBA-Gen Subjects 1810(3):308–316CrossRef
88.
Zurück zum Zitat Sad S, Dudani R, Gurnani K, Russell M, van Faassen H, Finlay B, Krishnan L (2008) Pathogen proliferation governs the magnitude but compromises the function of CD8 T cells. J Immunol 180(9):5853–5861CrossRef Sad S, Dudani R, Gurnani K, Russell M, van Faassen H, Finlay B, Krishnan L (2008) Pathogen proliferation governs the magnitude but compromises the function of CD8 T cells. J Immunol 180(9):5853–5861CrossRef
96.
Zurück zum Zitat Vogel A, Busch S, Jungnickel K, Birngruber R (1994) Mechanisms of intraocular photodisruption with picosecond and nanosecond laser pulses. Lasers Surg Med 15(1):32–43CrossRef Vogel A, Busch S, Jungnickel K, Birngruber R (1994) Mechanisms of intraocular photodisruption with picosecond and nanosecond laser pulses. Lasers Surg Med 15(1):32–43CrossRef
97.
Zurück zum Zitat Shaw S, Jin Y, Schiffers W, Emmony D (1996) The interaction of a single laser-generated cavity in water with a solid surface. J Acoust Soc Am 99(5):2811–2824CrossRef Shaw S, Jin Y, Schiffers W, Emmony D (1996) The interaction of a single laser-generated cavity in water with a solid surface. J Acoust Soc Am 99(5):2811–2824CrossRef
98.
99.
Zurück zum Zitat Sims CE, Meredith GD, Krasieva TB, Berns MW, Tromberg BJ, Allbritton NL (1998) Laser-micropipet combination for single-cell analysis. Anal Chem 70(21):4570–4577CrossRef Sims CE, Meredith GD, Krasieva TB, Berns MW, Tromberg BJ, Allbritton NL (1998) Laser-micropipet combination for single-cell analysis. Anal Chem 70(21):4570–4577CrossRef
104.
Zurück zum Zitat Waters LC, Jacobson SC, Kroutchinina N, Khandurina J, Foote RS, Ramsey JM (1998) Microchip device for cell lysis, multiplex PCR amplification, and electrophoretic sizing. Anal Chem 70(1):158–162CrossRef Waters LC, Jacobson SC, Kroutchinina N, Khandurina J, Foote RS, Ramsey JM (1998) Microchip device for cell lysis, multiplex PCR amplification, and electrophoretic sizing. Anal Chem 70(1):158–162CrossRef
Metadaten
Titel
Advances of Single-Cell Analysis on Microfluidics
verfasst von
Qiushi Huang
Jin-Ming Lin
Copyright-Jahr
2019
Verlag
Springer Singapore
DOI
https://doi.org/10.1007/978-981-32-9729-6_1

Neuer Inhalt