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2018 | OriginalPaper | Buchkapitel

Aerosol Therapy Development and Methods of Increasing Nebulization Effectiveness

verfasst von : Magdalena Matuszak, Marek Ochowiak, Michał Doligalski

Erschienen in: Practical Aspects of Chemical Engineering

Verlag: Springer International Publishing

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Abstract

In this chapter, the atomization process in medical nebulizers are analyzed on the basis of our own and literature results of the studies. It should be underlined that contemporary respiratory tract diseases belong to one of the most frequent and the fastest developing diseases in the world which people of wide age range fight with. Consequently, aerosol therapy belongs to constantly developing areas, which results in the advent of new and more effective pharmaceuticals as well as modern medical devices used in atomization of drugs. It is important to mention that the effectiveness of drug delivery to a patient’s respiratory tract depends on the knowledge and keeping the necessary rules of using inhaling methods under various conditions. The attempts presented in the article and regarding nebulization effectiveness increase showed a visible decrease of drop size of the generated aerosol while drop size histograms became more homogenous. Taking into consideration literature reports regarding inhalation therapy, you can come to the conclusion that nebulization of drugs constitutes an effective method in drug delivery to the respiratory system and can be widely implemented in medicine.

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Amirav I (2004) Aerosol therapy (Aerosol terapia). Ital J Pediatr 30:147–156

Andrade F, Rafael D, Videira M (2013) Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases. Adv Drug Deliv Rev 65:1816–1827CrossRef

Argent AC, Hatherill M, Newth CJL (2008) The effect of epinephrine by nebulization on measures of airway obstruction in patients with acute severe croup. Intensive Care Med 34:138–147CrossRef

Ari A, Hess D, Myers TR (2009) A guide to aerosol delivery devices for respiratory therapists, 2nd edn. Am Assoc Resp Care, Texas

Ashgriz N (2011) Handbook of atomization and sprays. Theory and applications. Springer Science Business Media, LLC, New YorkCrossRef

Beck-Broichsitter M, Kleimann P, Schmehl T (2012) Impact of lyoprotectants for the stabilization of biodegradable nanoparticles on the performance of air-jet, ultrasonic, and vibrating-mesh nebulizers. Eur J Pharm Biopharm 82:272–280CrossRef

Berkenfeld K, Lamprecht A, McConville JT (2015) Devices for dry powder drug delivery to the lung. AAPS Pharm Sci Tech 16(3):479–490CrossRef

Bisgaard H (1998) Targeting drugs to the respiratory tract. Res Immunol 149:229–331CrossRef

Bivas-Benita M, Ottenhoff TH, Junginger HE et al (2005) Pulmonary DNA vaccination: concepts, possibilities and perspectives. J Control Release 107:1–29CrossRef

Bosquillon C, Preat V, Vanbever R (2004) Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats. J Control Release 96:233–244CrossRef

Broniarz-Press L, Ochowiak M, Matuszak M et al (2014) The effect of shear and extensional viscosity on atomization in medical inhaler. Int J Pharm 468:199–206CrossRef

Brown JS, Zeman KL, Bennett WD (2001) Regional deposition of coarse particles and ventilation distribution in healthy subjects and patients with cystic fibrosis. J Aerosol Med 14:443–454CrossRef

Cassidy JP, Amin N, Marino M et al (2011) Insulin lung deposition and clearance following Technosphere®Insulin inhalation powder administration. Pharm Res 28:2157–2164CrossRef

Cefalu WT (2007) The new diabetes inhalers: new tools for the clinician. Curr Diabetes Rep 7:165–167CrossRef

Chan JGY, Wong J, Zhou QT et al (2014) Advances in device and formulation technologies for pulmonary drug delivery. AAPS Pharm Sci Tech 15(4):882–897CrossRef

Chow AHL, Tong HHY, Chattopadhyay P et al (2007) Particle engineering for pulmonary drug delivery. Pharm Res 24(3):411–437CrossRef

Cipolla DC, Gonda I (2011) Formulation technology to repurpose drugs for inhalation delivery. Drug Discov Today Ther Strateg 8(3–4):123–130CrossRef

Clay MM, Pavia D, Newman SP (1983) Assessment of jet nebulisers for lung aerosol therapy. Lancet 322(8350):592–594CrossRef

Dalby R, Spallek M, Voshaar T (2004) A review of the development of Respimat® Soft MistTM Inhaler. Int J Pharm 283:1–9CrossRef

Denyer J, Dyche T (2010) The adaptive aerosol delivery (AAD) technology: past, present, and future. J Aerosol Med Pulm Drug Deliv 23(1):1–10CrossRef

Depreter F, Amighi K (2010) Formulation and in vitro evaluation of highly dispersive insulin dry powder formulations for lung administration. Eur J Pharm Biopharm 76:454–463CrossRef

Dhand R (2002) Nebulizers that use a vibrating mesh or plate with multiple apertures to generate aerosol. Resp Care 47:1406–1416

Dijk PH, Heikamp A, Piers DA et al (1997) Surfactant nebulisation: safety, efficiency and influence on surface lowering properties and biochemical composition. Intensive Care Med 23:456–462CrossRef

Dilraj A, Cutts FT, de Castro JF et al (2000) Response to different measles vaccine strains given by aerosol and subcutaneous routes to schoolchildren: a randomised trial. Lancet 355:798–803CrossRef

Dolovich MB, Dhand R (2011) Aerosol drug delivery: developments in device design and clinical use. Lancet 377:1032–1045CrossRef

Elhissi AMA, Faizi M, Naji WF et al (2007) Physical stability and aerosol properties of liposomes delivered using an air-jet nebulizer and a novel micropump device with large mesh apertures. Int J Pharm 334:62–70CrossRef

Elhissi A, Gill H, Ahmed W et al (2011) Vibrating-mesh nebulization of liposomes generated using an ethanol-based proliposome technology. J Liposome Res 21:173–180CrossRef

Elliott D, Dunne P (2011) A guide to aerosol delivery devices for physicians, nurses, pharmacists, and other health care professionals. Am Assoc Resp Care, Texas

Ferron GA, Roth C (1998) A heat conservation model to estimate the temperature of aerosols from a jet nebulizer. J Aerosol Sci 29(1):763–764CrossRef

Ferron GA, Kerrebijn KF, Weber J (1976) Properties of aerosols produced with three nebulizers. Am Rev Respir Dis 114:899–908

Flament MP, Leterme P, Burnouf T et al (1997) Jet nebulisation: influence of dynamic conditions and nebuliser on nebulisation quality. Application to the α1 protease inhibitor. Int J Pharm 148:93–101CrossRef

Gill DR, Davies LA, Pringle IA et al (2004) The development of gene therapy for diseases of the lung. Cell Mol Life Sci 61:355–368CrossRef

Gomez A (2002) The electrospray and its application to targeted drug inhalation. Respir Care 47:1419–1433

Hess DR (2008) Aerosol delivery devices in the treatment of asthma. Respir Care 53(6):699–725

Hodder R, Price D (2009) Patient preferences for inhaler devices in chronic obstructive pulmonary disease: experience with Respimat Soft Mist Inhaler. Int J Chron Obstructive Pulmon Dis 4:381–390CrossRef

Hodder R, Reese PR, Slaton T (2009) Asthma patients prefer Respimat Soft Mist Inhaler to Turbuhaler. Int J Chron Obstructive Pulmon Dis 4:225–232CrossRef

Iacono P, Velicitat P, Guemas E et al (2000) Improved delivery of ipratropium bromide using Respimat® (a new soft mist inhaler) compared with a conventional metered dose inhaler: cumulative dose response study in patients with COPD. Respir Med 94:490–495CrossRef

Isaev IV, Morozov VY (2005) Dosing of low concentration anesthetics with evaporators used in inhalation anesthesia apparatuses. Biomed Eng 39(6):299–300CrossRef

Jaworek A (2007) Micro- and nanoparticle production by electrospraying. Powder Technol 176:18–35CrossRef

Johnson JC, Waldrep JC, Guo J et al (2008) Aerosol delivery of recombinant human DNase I: in vitro comparison of a vibrating-mesh nebulizer with a jet nebulizer. Respir Care 53(12):1703–1708

Kamijyo A, Matsuzaki Z, Kikushima K et al (2001) Fosfomycin nebulizer therapy to chronic sinusitis. Auris Nas L 28:227–232CrossRef

Kesser KC, Geller DE (2009) New aerosol delivery devices for cystic fibrosis. Respir Care 54(6):754–767CrossRef

Khilnani GC, Banga A (2008) Aerosol therapy. Indian J Chest Dis Allied Sci 50(2):209–220

Kleemann E, Dailey LA, Abdelhady HG et al (2004) Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy: investigations of the complex structure and stability during air-jet and ultrasonic nebulization. J Control Release 100:437–450CrossRef

Kwok PCL, Chan HK (2014) Delivery of inhalation drugs to children for asthma and other respiratory diseases. Adv Drug Deliv Rev 73:83–88CrossRef

Lass JS, Sant A, Knoch M (2006) New advances in aerosolised drug delivery: vibrating membrane nebuliser technology. Expert Opin Drug Deliv 3:693–702CrossRef

Lefebvre AH (1989) Atomization and sprays. Hemisphere Publishing Corporation, New York

Lentz YK, Worden LR, Anchordoquy TJ (2005) Effect of jet nebulization on DNA: identifying the dominant degradation mechanism and mitigation methods. Aerosol Sci 36:973–990CrossRef

Lentz YK, Anchordoquy TJ, Lengsfeld CS (2006) Rationale for the selection of an aerosol delivery system for gene delivery. J Aerosol Med 19:372–384CrossRef

Lewis RA (1983) Nebulisers for lung aerosol therapy. Lancet 322(8354):849CrossRef

Lewis JF, Ikegami M, Jobe AH (1991) Aerosolized surfactant treatment of preterm lambs. J Appl Physiol 70(2):869–876CrossRef

Lewis JF, Tabor B, Ikegami M et al (1993) Lung function and surfactant distribution in saline lavaged sheep given instilled vas nebulized surfactant. J Appl Physiol 74(3):1256–1264CrossRef

Licalsi C, Christensen C, Bennett T et al (1999) Dry powder in-halation as a potential delivery method for vaccines. Vaccine 17:1796–1803CrossRef

Longest PW, Spence BM, Holbrook LT et al (2012) Production of inhalable submicrometer aerosols from conventional mesh nebulizers for improved respiratory drug delivery. J Aerosol Sci 51:66–80CrossRef

Luisettia M, Kroneberg P, Suzuki T et al (2011) Physical properties, lung deposition modeling, and bioactivity of recombinant GM-CSF aerosolised with a highly efficient nebulizer. Pulm Pharmacol Ther 24:123–127CrossRef

Lyutov GP (2006) Methods for increasing the efficiency of aerosol inhalers. Biom Eng 40(1):1–3CrossRef

Marianecci C, Di Marzio L, Rinaldi F et al (2011) Pulmonary delivery: innovative approaches and perspectives. J Biomater Nanobiotechnol 2:567–575CrossRef

Markuszewska M (2011) Projekt dyszy pęcherzykowej. Poznan University of Technology, Poznan

Matuszak M, Ochowiak M, Włodarczak S (2017) Metody poprawy efektywności procesu rozpylania w nebulizatorach pneumatycznych. Inż Ap Chem 56(3):90–91

McCallion ONM, Taylor KMG, Thomas M et al (1995) Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers. Pharm Res 12(11):1682–1688CrossRef

McCallion ONM, Taylor KMG, Bridges PA et al (1996) Jet nebulisers for pulmonary drug delivery. Int J Pharm 130:1–11CrossRef

Mohajel N, Najafabadi AR, Azadmanesh K et al (2012) Optimization of a spray drying process to prepare dry powder microparticles containing plasmid nanocomplex. Int J Pharm 423:577–585CrossRef

Najlah M, Vali A, Taylor M et al (2013) A study of the effects of sodium halides on the performance of air-jet and vibrating-mesh nebulizers. Int J Pharm 456:520–527CrossRef

Najlah M, Parveen I, Alhnan MA et al (2014) The effects of suspension particle size on the performance of air-jet, ultrasonic and vibrating-mesh nebulisers. Int J Pharm 461:234–241CrossRef

Newman SP, Pellow PGD, Clarke SW (1986) Droplet size distributions of nebulised aerosols for inhalation therapy. Clin Phys Physiol Meas 7(2):139–146CrossRef

Niven RW, Brain JD (1994) Some functional aspects of air-jet nebulizers. Int J Pharm 104:73–85CrossRef

O’Callaghan C, Barry PW (1997) The science of nebulised drug delivery. Thorax 52(2):31–44CrossRef

Ochowiak M, Matuszak M (2017) The effect of additional aeration of liquid on the atomization process for a pneumatic nebulizer. Eur J Pharm Sci 97:99–105CrossRef

Ochowiak M, Doligalski M, Broniarz-Press L et al (2016) Characterization of sprays for thermo-stabilized pneumatic nebulizer. Eur J Pharm Sci 85:53–58CrossRef

Odziomek M, Sosnowski TR, Gradoń L (2012) Conception, preparation and properties of functional carrier particles for pulmonary drug delivery. Int J Pharm 433:51–59CrossRef

Olveira C, Muñoz A, Domenech A (2014) Nebulized therapy. SEPAR Year. Arch Bronconeumol 50(12):535–545CrossRef

Pahwa R, Pankaj G, Singh M et al (2012) Nebulizer therapy: a platform for pulmonary drug delivery. Der Pharmacia Sinica 3(6):630–636

Park JH, Jin HE, Kim DD et al (2013) Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation. Int J Pharm 441:562–569CrossRef

Petersen FJ (2004) A new approach for pharmaceutical sprays. Effervescent atomization. atomizer design and spray characterization. Ph.D. thesis, Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Copenhagen

Pilcer G, Amighi K (2010) Formulation strategy and use of excipients in pulmonary drug delivery. Int J Pharm 392:1–19CrossRef

Robbins PD, Evans CH, Chernajovsky Y (2003) Gene therapy for arthritis. Gene Ther 10:902–911CrossRef

Salama RO, Young PM, Traini D (2014) Concurrent oral and inhalation drug de-livery using a dual formulation system: the use of oral theophylline carrier with combined inhalable budesonide and terbutaline. Drug Deliv and Transl Res 4:256–267CrossRef

Shah S (2011) Exogenous surfactant: intubated present, nebulized future? World J Pediatr 7(1):11–15CrossRef

Sheth P, Stein SW, Myrdal PB (2015) Factors influencing aerodynamic particle size distribution of suspension pressurized metered dose inhalers. AAPS Pharm Sci Tech 16(1):192–201CrossRef

Shoyele SA, Cawthorne S (2006) Particle engineering techniques for inhaled bio-pharmaceuticals. Adv Drug Deliv Rev 58:1009–1029CrossRef

Shoyele SA, Slowey A (2006) Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery. Int J Pharm 314:1–8CrossRef

Soll RF, Merritt TA, Hallman M (1994) Surfactant in the prevention and treatment of respiratory distress syndrome. In: Boynton BR (ed) New therapies for neonatal respiratory failure. Cambridge University Press, Cambridge, pp 49–80

Sosnowski TR (2012) Aerozole wziewne i inhalatory. Warsaw University of Technology, Warsaw

Steckel H, Eskandar F (2003) Factors affecting aerosol performance during nebulization with jet and ultrasonic nebulizers. Eur J Pharm Sci 19:443–455CrossRef

Taylor KMG, Venthoye G, Chawla A (1992) Pentamidine isethionate delivery from jet nebulisers. Int J Pharm 85:203–208CrossRef

Terzano C, Allegra L (2002) Importance of drug delivery system in steroid aerosol therapy via nebulizer. Pulm Pharmacol Ther 15:449–454CrossRef

Vaughan WC (2004) Nebulization of antibiotics in management of sinusitis. Curr Infect Dis Rep 6:187–190CrossRef

Vecellio L, Abdelrahim ME, Montharu J et al (2011) Disposable versus reusable jet nebulizers for cystic fibrosis treatment with tobramycin. J Cyst Fibros 10:86–92CrossRef

Wang YB, Watts AB, Peters JI et al (2014) In vitro and in vivo performance of dry powder inhalation formulations: comparison of particles prepared by thin film freezing and micronization. AAPS Pharm Sci Tech 15(4):281–993

Wanning S, Süverkrüp R, Lamprecht A (2015) Pharmaceutical spray freeze drying. Int J Pharm 488:136–153CrossRef

Willis L, Hayes DJr, Mansour HM (2012) Therapeutic liposomal dry powder inhalation aerosols for targeted lung delivery. Lung 190:251–262

Yeo LY, Friend JR, McIntosh MP et al (2010) Ultrasonic nebulization platforms for pulmonary drug delivery. Exp Opin Drug Deliv 7(6):663–679CrossRef

Zhou QT, Tang P, Leung SSY et al (2014) Emerging inhala-tion aerosol devices and strategies: where are we headed? Adv Drug Deliv Rev 75:3–17CrossRef

Zou Y, Tornos C, Qiu X et al (2007) p53 aerosol formulation with low toxicity and high efficiency for early lung cancer treatment. Clin Cancer Res 13:4900–4908CrossRef

Titel: Aerosol Therapy Development and Methods of Increasing Nebulization Effectiveness
verfasst von: Magdalena Matuszak
Marek Ochowiak
Michał Doligalski
Verlag: Springer International Publishing
Buch: Practical Aspects of Chemical Engineering
Print ISBN: 978-3-319-73977-9

Electronic ISBN: 978-3-319-73978-6

Copyright-Jahr: 2018
DOI: https://doi.org/10.1007/978-3-319-73978-6_19