Algorithms for Use in Purity Control of Drugs Using UV-Spectroscopy

UV-spectroscopy is a nonspecific analytical method, but in contrast to this it is possible to develop methods for purity control of drugs using this type of spectroscopy. Two algorithms will be described in this paper: a differential method subtracting the spectra of the analysis and a reference followed by nonparametric tests and the rank of a matrix containing both spectra. Base of both methods is a sophisticated comparison of both spectra. With two examples will be confirmed the proposed method. In some cases it is possible to detect impurities below 0.1%.