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Erschienen in:
2021 | OriginalPaper | Buchkapitel
An Optimal Response-Adaptive Design for Multi-treatment Clinical Trials with Circular Responses
verfasst von : Taranga Mukherjee, Rahul Bhattacharya, Atanu Biswas
Erschienen in: Applied Advanced Analytics
Verlag: Springer Singapore
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Abstract
Circular or directional outcomes are natural responses in many clinical trials (e.g. orthopedics, ophthalmology, sports medicine). Traditionally, clinical trials use equal allocation throughout the trial without utilizing the information contained in the sequentially observed responses in the running trial. Adaptive allocation designs are data-dependent alternatives to assign a greater number of subjects to the better performing treatments using the available data of the running trial in a convenient way. However, adaptive designs for circular responses are rare and, therefore, in the current work, we develop a multi-treatment response-adaptive randomization for circular treatment outcomes considering both the ethics and efficiency requirements. Apart from assessing the proposed allocation design empirically, the applicability of the design in real clinical trials is also enumerated from a practitioner’s viewpoint.