Neoplastic transformation occurs with chemical carcinogens that interact with DNA such as carcinogenic polycyclic hydrocarbons, inorganic metals, N-Acetoxy-florenylacetamide and its derivatives and alkylating agents (1). Transformation resulting in malignancy also occurs with non-mutagenic agents including SO2− (sodium bisulfite). With chemicals alone or in combination with X-irradiation the incidence of transformed hamster colonies fits a one hit curve indicating that the phenomenon is inductive (2).
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- Analysis of Transforming Sequences in Neoplastic Syrian Hamster Fetal Cells Induced by Diverse Chemical Carcinogens
J. A. DiPaolo
- Springer Berlin Heidelberg