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Erschienen in:
2020 | OriginalPaper | Buchkapitel
Analyzing the Immune Response of Neoepitopes for Personalized Vaccine Design
verfasst von : Iker Malaina, Leire Legarreta, Mª Dolores Boyano, Santos Alonso, Ildefonso M. De la Fuente, Luis Martinez
Erschienen in: Bioinformatics and Biomedical Engineering
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Abstract
In the last few years, the importance of neoepitopes for the development of personalized antitumor vaccines has increased remarkably. This kind of epitopes are considered to generate a strong immune reaction, while their non-mutated version, which sometimes differs only in a single amino-acid, does not generate a response at all. In order to study if, regardless the immune tolerance, neoepitopes are quantitatively more immunogenic than the original strings, we have obtained samples of mutated and non-mutated epitopes of six patients with cutaneous melanoma in different stages, and then we have compared them. More precisely, we have used several bioinformatic tools to study certain properties of the epitopes such as the HLA binding affinity of classes I and II, and found that some of them are in fact increased in their mutated versions, which supports the hypothesis, and also reinforces the use of neoepitopes for cancer vaccine design.