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2013 | OriginalPaper | Buchkapitel

16. Anti-adhesive and Antibacterial Polymer Brushes

verfasst von : K. G. Neoh, Z. L. Shi, E. T. Kang

Erschienen in: Biomaterials Associated Infection

Verlag: Springer New York

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Abstract

Bacterial infection associated with medical devices is a serious complication. One promising strategy to combat this problem is the functionalization of the device surface with a dense layer of polymer chains which can resist bacterial adhesion and colonization. These polymer chains may present large exclusion volumes to inhibit protein and bacterial adhesion and/or possess bactericidal functional groups. The coating of surfaces with these polymers may be carried out via a number of techniques such as self-assembly, grafting and surface-initiated polymerization. This article focuses mainly on polymer coatings which achieved the antibacterial effect without the leaching of the bactericidal components into the environment.

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Vorheriges Kapitel Quaternary Ammonium Compounds

Nächstes Kapitel Infection in Fracture Fixation: Device Design and Antibiotic Coatings Reduce Infection Rates

Bactericidal

Capable of destroying bacteria

Biofilm

An organized community of bacteria growing on a surface

Biomimetic

Biologically inspired

Chelator

A chemical that combines with metal ions and remove them from solution

Heterolinker

A molecule with dissimilar functional groups used for coupling other molecules

Hyperbranched

Multibranching structure

Inimer

A compound which contains both a polymerizable group and a group able to initiate polymerization by forming active species

Isoelectric point

The pH value at which a particular molecule or surface carries no net electrical charge

LCST

Lower critical solution temperature is the temperature below which a mixture is miscible

Macroinitiator

A polymer or oligomer which can initiate a polymerization reaction

PEGylation

Chemical process of modifying a molecule or surface with polyethylene glycol (PEG)

Physi-sorption

Process of adsorption where there is minimal perturbation of the electronic states of the adsorbed molecule and the surface. Also known as physical adsorption

Zwitterionic

A molecule which carries both a positive and a negative charge

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Titel: Anti-adhesive and Antibacterial Polymer Brushes
verfasst von: K. G. Neoh
Z. L. Shi
E. T. Kang
Verlag: Springer New York
Buch: Biomaterials Associated Infection
Print ISBN: 978-1-4614-1030-0

Electronic ISBN: 978-1-4614-1031-7

Copyright-Jahr: 2013
DOI: https://doi.org/10.1007/978-1-4614-1031-7_16

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