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2015 | OriginalPaper | Buchkapitel

4. Anti-cancer Activity of Selected Seaweeds Against HeLa, K-562 and MDA-MB Cell Lines

verfasst von : Ilahi Shaik, A. Shameem, P. Sasi Bhushana Rao

Erschienen in: Biotechnology and Bioforensics

Verlag: Springer Singapore

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Abstract

Anticancer activity of marine macro algae (seaweeds) Sargassum wightii, Ulva fasciata and Gracillaria corticata against HeLa, K-562 and MDA-MB cell lines was studied. During the present investigation crude extracts of seaweeds were prepared using soxhlet apparatus. Hexane, Butanol and Methanol were used as solvents. Crude extracts were dissolved in DMSO. In vitro anticancer activity of seaweeds at various concentrations (12.5–200 μg/ml) was studied against the chosen cell lines using MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a yellow tetrazole). Butanolic extract of Gracillaria corticata (200 µg/ml) has shown greater anticancer activity than hexane and methanolic extracts of G. corticata and butanol, hexane and methanolic extracts of Sargassum wightii and Ulva fasciata.

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Literatur
1.
Zurück zum Zitat Blunden G (1993) Marine algae as sources of biologically active compounds. Interdisc Sci Rev 18:73–80CrossRef Blunden G (1993) Marine algae as sources of biologically active compounds. Interdisc Sci Rev 18:73–80CrossRef
2.
Zurück zum Zitat Smit AJ (2004) Medicinal and pharmaceutical uses of seaweed natural products: a review. J Appl Phycol 16:245–262CrossRef Smit AJ (2004) Medicinal and pharmaceutical uses of seaweed natural products: a review. J Appl Phycol 16:245–262CrossRef
3.
Zurück zum Zitat Manilal A, Sujith S, Kiran GS, Selvin J, Shikar C (2009) Cytotoxic potentials of red alga, Laurencia brandenii collected from the Indian Coast. Global J Pharmacol 3:90–94 Manilal A, Sujith S, Kiran GS, Selvin J, Shikar C (2009) Cytotoxic potentials of red alga, Laurencia brandenii collected from the Indian Coast. Global J Pharmacol 3:90–94
4.
Zurück zum Zitat Harada H, Noro T, Kamei Y (1997) Selective antitumor activity in vitro from marine algae from Japan coast. Biol Pharm Bull 20:541–546CrossRef Harada H, Noro T, Kamei Y (1997) Selective antitumor activity in vitro from marine algae from Japan coast. Biol Pharm Bull 20:541–546CrossRef
5.
Zurück zum Zitat Uma Maheswara Rao M, Sreeramulu T (1970) An annotated list of the marine algae of Visakhapatnam (India). Bot J Linn Soc 63:23–45CrossRef Uma Maheswara Rao M, Sreeramulu T (1970) An annotated list of the marine algae of Visakhapatnam (India). Bot J Linn Soc 63:23–45CrossRef
6.
Zurück zum Zitat Dharallear VK, Kavlekar DP (2004) Seaweeds: a field manual. National Institute of Oceanography, Goa Dharallear VK, Kavlekar DP (2004) Seaweeds: a field manual. National Institute of Oceanography, Goa
7.
Zurück zum Zitat Sambarmurty AVSS (2005) A text book of algae. I.K. International Pvt Ltd, New Delhi, pp 65–97 Sambarmurty AVSS (2005) A text book of algae. I.K. International Pvt Ltd, New Delhi, pp 65–97
8.
Zurück zum Zitat Hashimoto Y (1979) Marine toxins and other bioactive marine metabolites. Japan Scientific Societies Press, Tokyo, p 369 Hashimoto Y (1979) Marine toxins and other bioactive marine metabolites. Japan Scientific Societies Press, Tokyo, p 369
9.
Zurück zum Zitat Naqvi SWA, Kamat SY, Fernandes L, Reddy CVG, Bhakuni DS, Dhawan BN (1980) Screening of some marine plants from the Indian coast for biological activity. Bot Mar 24(1):51-55 Naqvi SWA, Kamat SY, Fernandes L, Reddy CVG, Bhakuni DS, Dhawan BN (1980) Screening of some marine plants from the Indian coast for biological activity. Bot Mar 24(1):51-55
10.
Zurück zum Zitat Barbier M (1981) Marine chemical ecology: the roles of chemical communication and chemical pollution. In: Scheuer PJ (ed) Marine natural products: chemical and biological prospectives, vol 4. Academic Press Inc., New York, pp 148–186 Barbier M (1981) Marine chemical ecology: the roles of chemical communication and chemical pollution. In: Scheuer PJ (ed) Marine natural products: chemical and biological prospectives, vol 4. Academic Press Inc., New York, pp 148–186
11.
Zurück zum Zitat Scheuer Paul J (ed) (1982) Marine natural products: chemical and biological prospectives, vol 1–5. Academic Press Inc., New York Scheuer Paul J (ed) (1982) Marine natural products: chemical and biological prospectives, vol 1–5. Academic Press Inc., New York
12.
Zurück zum Zitat Faukner DJ (1984) Marine natural products: metabolites of marine algae and herbivorous marine mollusks. Nat Product Rep 1:251CrossRef Faukner DJ (1984) Marine natural products: metabolites of marine algae and herbivorous marine mollusks. Nat Product Rep 1:251CrossRef
13.
Zurück zum Zitat Hatano T, Kagawa H, Yasuhara T (1988) Evaluation of marine algae Ulva lactuca. L as a source of Natural Preservative Ingredient. American-Eurasian J Agric Environ Sci 3:434–444 Hatano T, Kagawa H, Yasuhara T (1988) Evaluation of marine algae Ulva lactuca. L as a source of Natural Preservative Ingredient. American-Eurasian J Agric Environ Sci 3:434–444
14.
Zurück zum Zitat Mayer AMS, Lehmann VKB (2000) Marine pharmacology in 1998: Marine compounds with antibacterial, anticoagulant, anti-inflammatory, anthelmintic, antiplatelet, antiprotozoan, and antiviral activities; with actions on the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action. Pharmacologist 42:62–69 Mayer AMS, Lehmann VKB (2000) Marine pharmacology in 1998: Marine compounds with antibacterial, anticoagulant, anti-inflammatory, anthelmintic, antiplatelet, antiprotozoan, and antiviral activities; with actions on the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action. Pharmacologist 42:62–69
15.
Zurück zum Zitat Awad NE (2000) Biologically active steroid from the green alga Ulva lactuca. Phytother Res 14:641–643CrossRef Awad NE (2000) Biologically active steroid from the green alga Ulva lactuca. Phytother Res 14:641–643CrossRef
16.
Zurück zum Zitat Chakraborty K, Paulraj R (2010) Sesquiterpenoids with free-radical-scavenging properties from marine macroalga Ulva fasciata Delile. Food Chem 122:31–41CrossRef Chakraborty K, Paulraj R (2010) Sesquiterpenoids with free-radical-scavenging properties from marine macroalga Ulva fasciata Delile. Food Chem 122:31–41CrossRef
17.
Zurück zum Zitat Ribeiro-do-Valle RM (2005) Antiangiogenic and antitumoral properties of polysaccharide isolated from the seaweed Sargassum stenophyllum. Cancer Chemother Pharmacol 56:436–446CrossRef Ribeiro-do-Valle RM (2005) Antiangiogenic and antitumoral properties of polysaccharide isolated from the seaweed Sargassum stenophyllum. Cancer Chemother Pharmacol 56:436–446CrossRef
18.
Zurück zum Zitat Albano RM, Pavao MS, Mourao PA, Mulloy B (1990) Structural studies of a sulfated L-galactan from Styela plicata (Tunicate): analysis of the smith-degraded polysaccharide. Carbohydr Res 208:163–167CrossRef Albano RM, Pavao MS, Mourao PA, Mulloy B (1990) Structural studies of a sulfated L-galactan from Styela plicata (Tunicate): analysis of the smith-degraded polysaccharide. Carbohydr Res 208:163–167CrossRef
19.
Zurück zum Zitat Zandi K, Ahmadzadeh S, Tajbakhsh S, Rastian Z, Yousefi F, Farshadpour F, Sartavi K (2007) Anticancer activity of Sargassum oligocystum water extract against human cancer cell lines. Phytother Res 21:170–175CrossRef Zandi K, Ahmadzadeh S, Tajbakhsh S, Rastian Z, Yousefi F, Farshadpour F, Sartavi K (2007) Anticancer activity of Sargassum oligocystum water extract against human cancer cell lines. Phytother Res 21:170–175CrossRef
20.
Zurück zum Zitat Sundaram M, Patra S, Maniarasu G (2012) Antitumor activity of ethanol extract of Gracilaria edulis (Gmelin) Silva on Ehrlich ascites carcinoma-bearing mice. J Chin Integr Med/Zhong Xi Yi Jie He Xue Bao 10(4):430–435CrossRef Sundaram M, Patra S, Maniarasu G (2012) Antitumor activity of ethanol extract of Gracilaria edulis (Gmelin) Silva on Ehrlich ascites carcinoma-bearing mice. J Chin Integr Med/Zhong Xi Yi Jie He Xue Bao 10(4):430–435CrossRef
21.
Zurück zum Zitat John MC (1995) Lipid peroxidation and antioxidants as biomarkers for tissue damage European Beckmen Conference. Clinical Chem 41(12):1819–1828 John MC (1995) Lipid peroxidation and antioxidants as biomarkers for tissue damage European Beckmen Conference. Clinical Chem 41(12):1819–1828
22.
Zurück zum Zitat Han X, Shen T, Lou H (2007) Dietary polyphenols and their biological significance. Int J Mol Sci 8:950–988CrossRef Han X, Shen T, Lou H (2007) Dietary polyphenols and their biological significance. Int J Mol Sci 8:950–988CrossRef
23.
Zurück zum Zitat Abd El-Baky HH, El Baz FK, Gamal SE, Baroty I (2008) Evaluation of marine alga Ulva lactuca L. as a source of natural preservative ingredient. American-Eurasian J Agric Environ Sci 3(3):434–444 Abd El-Baky HH, El Baz FK, Gamal SE, Baroty I (2008) Evaluation of marine alga Ulva lactuca L. as a source of natural preservative ingredient. American-Eurasian J Agric Environ Sci 3(3):434–444
Metadaten
Titel
Anti-cancer Activity of Selected Seaweeds Against HeLa, K-562 and MDA-MB Cell Lines
verfasst von
Ilahi Shaik
A. Shameem
P. Sasi Bhushana Rao
Copyright-Jahr
2015
Verlag
Springer Singapore
DOI
https://doi.org/10.1007/978-981-287-050-6_4

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