Skip to main content

2017 | OriginalPaper | Buchkapitel

Assisting the Diagnosis of Neurodegenerative Disorders Using Principal Component Analysis and TensorFlow

verfasst von : Fermín Segovia, Marcelo García-Pérez, Juan Manuel Górriz, Javier Ramírez, Francisco Jesús Martínez-Murcia

Erschienen in: International Joint Conference SOCO’16-CISIS’16-ICEUTE’16

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Neuroimaging data provides a valuable tool to assist the diagnosis of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). During last years many research efforts have focused on the development of computer systems that automatically analyze neuroimaging data and allow improving the diagnosis of those diseases. This field has benefited from modern machine learning techniques, which provide a higher generalization ability, however the high dimensionality of the data is still a challenge and there is room for improvement. In this work we demonstrate a computer system based on Principal Component Analysis and TensorFlow, the machine learning library recently released by Google. The proposed system is able to successfully separate AD or PD patients from healthy subjects, as well as distinguishing between PD and other parkinsonian syndromes. The obtained results suggest that TensorFlow is a suitable environment to classify neuroimaging data and can help to improve the diagnosis of AD and Parkinsonism.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
2.
Zurück zum Zitat Abadi, M., Agarwal, A., Barham, P., Brevdo, E., Chen, Z., Citro, C., Corrado, G.S., Davis, A., Dean, J., Devin, M., Ghemawat, S., Goodfellow, I., Harp, A., Irving, G., Isard, M., Jia, Y., Jozefowicz, R., Kaiser, L., Kudlur, M., Levenberg, J., Mané, D., Monga, R., Moore, S., Murray, D., Olah, C., Schuster, M., Shlens, J., Steiner, B., Sutskever, I., Talwar, K., Tucker, P., Vanhoucke, V., Vasudevan, V., Viégas, F., Vinyals, O., Warden, P., Wattenberg, M., Wicke, M., Yu, Y., Zheng, X.: TensorFlow: large-scale machine learning on heterogeneous systems (2015). http://tensorflow.org/, software available from tensorow.org Abadi, M., Agarwal, A., Barham, P., Brevdo, E., Chen, Z., Citro, C., Corrado, G.S., Davis, A., Dean, J., Devin, M., Ghemawat, S., Goodfellow, I., Harp, A., Irving, G., Isard, M., Jia, Y., Jozefowicz, R., Kaiser, L., Kudlur, M., Levenberg, J., Mané, D., Monga, R., Moore, S., Murray, D., Olah, C., Schuster, M., Shlens, J., Steiner, B., Sutskever, I., Talwar, K., Tucker, P., Vanhoucke, V., Vasudevan, V., Viégas, F., Vinyals, O., Warden, P., Wattenberg, M., Wicke, M., Yu, Y., Zheng, X.: TensorFlow: large-scale machine learning on heterogeneous systems (2015). http://​tensorflow.​org/​, software available from tensorow.org
3.
Zurück zum Zitat Bach, J., Ziegler, U., Deuschl, G., Dodel, R., Doblhammer-Reiter, G.: Projected numbers of people with movement disorders in the years 2030 and 2050. Mov. Disord. 26(12), 2286–2290 (2011)CrossRef Bach, J., Ziegler, U., Deuschl, G., Dodel, R., Doblhammer-Reiter, G.: Projected numbers of people with movement disorders in the years 2030 and 2050. Mov. Disord. 26(12), 2286–2290 (2011)CrossRef
4.
Zurück zum Zitat Brookmeyer, R., Johnson, E., Ziegler-Graham, K., Arrighi, H.M.: Forecasting the global burden of Alzheimer’s disease. Alzheimer’s Dement. J. Alzheimer’s Assoc. 3(3), 186–191 (2007)CrossRef Brookmeyer, R., Johnson, E., Ziegler-Graham, K., Arrighi, H.M.: Forecasting the global burden of Alzheimer’s disease. Alzheimer’s Dement. J. Alzheimer’s Assoc. 3(3), 186–191 (2007)CrossRef
5.
Zurück zum Zitat Duin, R.: Classifiers in almost empty spaces. In: Proceedings of 15th International Conference on Pattern Recognition, vol. 2, pp. 1–7 (2000) Duin, R.: Classifiers in almost empty spaces. In: Proceedings of 15th International Conference on Pattern Recognition, vol. 2, pp. 1–7 (2000)
6.
Zurück zum Zitat Foster, N.L., Heidebrink, J.L., Clark, C.M., Jagust, W.J., Arnold, S.E., Barbas, N.R., DeCarli, C.S., Turner, R.S., Koeppe, R.A., Higdon, R., Minoshima, S.: FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer’s disease. Brain 130(10), 2616–2635 (2007)CrossRef Foster, N.L., Heidebrink, J.L., Clark, C.M., Jagust, W.J., Arnold, S.E., Barbas, N.R., DeCarli, C.S., Turner, R.S., Koeppe, R.A., Higdon, R., Minoshima, S.: FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer’s disease. Brain 130(10), 2616–2635 (2007)CrossRef
7.
Zurück zum Zitat Fougère, C.I., Pöpperl, G., Levin, J., Wängler, B., Böning, G., Uebleis, C., Cumming, P., Bartenstein, P., Bötzel, K., Tatsch, K.: The value of the dopamine D2/3 receptor ligand 18F-Desmethoxyfallypride for the differentiation of idiopathic and nonidiopathic parkinsonian syndromes. J. Nucl. Med. 51(4), 581–587 (2010)CrossRef Fougère, C.I., Pöpperl, G., Levin, J., Wängler, B., Böning, G., Uebleis, C., Cumming, P., Bartenstein, P., Bötzel, K., Tatsch, K.: The value of the dopamine D2/3 receptor ligand 18F-Desmethoxyfallypride for the differentiation of idiopathic and nonidiopathic parkinsonian syndromes. J. Nucl. Med. 51(4), 581–587 (2010)CrossRef
8.
Zurück zum Zitat Friston, K., Büchel, C.: Functional connectivity: eigenimages and multivariate analyses. In: Friston, K., Ashburner, J., Kiebel, S., Nichols, T., Penny, W. (eds.) Statistical Parametric Mapping, Chap. 37, pp. 492–507. Academic Press, London (2007)CrossRef Friston, K., Büchel, C.: Functional connectivity: eigenimages and multivariate analyses. In: Friston, K., Ashburner, J., Kiebel, S., Nichols, T., Penny, W. (eds.) Statistical Parametric Mapping, Chap. 37, pp. 492–507. Academic Press, London (2007)CrossRef
9.
Zurück zum Zitat Friston, K.J., Ashburner, J.T., Kiebel, S.J., Nichols, T.E., Penny, W.D.: Statistical Parametric Mapping: The Analysis of Functional Brain Images, 1st edn. Academic Press, Amsterdam, Boston (2006) Friston, K.J., Ashburner, J.T., Kiebel, S.J., Nichols, T.E., Penny, W.D.: Statistical Parametric Mapping: The Analysis of Functional Brain Images, 1st edn. Academic Press, Amsterdam, Boston (2006)
10.
Zurück zum Zitat Gilman, S., Wenning, G.K., Low, P.A., Brooks, D.J., Mathias, C.J., Trojanowski, J.Q., Wood, N.W., Colosimo, C., Dürr, A., Fowler, C.J., Kaufmann, H., Klockgether, T., Lees, A., Poewe, W., Quinn, N., Revesz, T., Robertson, D., Sandroni, P., Seppi, K., Vidailhet, M.: Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71(9), 670–676 (2008)CrossRef Gilman, S., Wenning, G.K., Low, P.A., Brooks, D.J., Mathias, C.J., Trojanowski, J.Q., Wood, N.W., Colosimo, C., Dürr, A., Fowler, C.J., Kaufmann, H., Klockgether, T., Lees, A., Poewe, W., Quinn, N., Revesz, T., Robertson, D., Sandroni, P., Seppi, K., Vidailhet, M.: Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71(9), 670–676 (2008)CrossRef
11.
Zurück zum Zitat Hughes, A.J., Daniel, S.E., Ben-Shlomo, Y., Lees, A.J.: The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 125(4), 861–870 (2002)CrossRef Hughes, A.J., Daniel, S.E., Ben-Shlomo, Y., Lees, A.J.: The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain 125(4), 861–870 (2002)CrossRef
12.
Zurück zum Zitat Illán, I.A., Górriz, J.M., Ramírez, J., Segovia, F., Jiménez-Hoyuela, J.M., Lozano, S.J.O.: Automatic assistance to parkinson’s disease diagnosis in DaTSCAN SPECT imaging. Med. Phys. 39(10), 5971–5980 (2012)CrossRef Illán, I.A., Górriz, J.M., Ramírez, J., Segovia, F., Jiménez-Hoyuela, J.M., Lozano, S.J.O.: Automatic assistance to parkinson’s disease diagnosis in DaTSCAN SPECT imaging. Med. Phys. 39(10), 5971–5980 (2012)CrossRef
13.
Zurück zum Zitat Koch, W., Radau, P.E., Hamann, C., Tatsch, K.: Clinical testing of an optimized software solution for an automated, observer-independent evaluation of dopamine transporter SPECT studies. J. Nucl. Med. 46(7), 1109–1118 (2005) Koch, W., Radau, P.E., Hamann, C., Tatsch, K.: Clinical testing of an optimized software solution for an automated, observer-independent evaluation of dopamine transporter SPECT studies. J. Nucl. Med. 46(7), 1109–1118 (2005)
14.
Zurück zum Zitat Litvan, I., Agid, Y., Calne, D., Campbell, G., Dubois, B., Duvoisin, R.C., Goetz, C.G., Golbe, L.I., Grafman, J., Growdon, J.H., Hallett, M., Jankovic, J., Quinn, N.P., Tolosa, E., Zee, D.S.: Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47(1), 1–9 (1996)CrossRef Litvan, I., Agid, Y., Calne, D., Campbell, G., Dubois, B., Duvoisin, R.C., Goetz, C.G., Golbe, L.I., Grafman, J., Growdon, J.H., Hallett, M., Jankovic, J., Quinn, N.P., Tolosa, E., Zee, D.S.: Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology 47(1), 1–9 (1996)CrossRef
15.
Zurück zum Zitat Lopez, M., Ramirez, J., Gorriz, J., Salas-Gonzalez, D., Alvarez, I., Segovia, F., Puntonet, C.G.: Automatic tool for Alzheimer’s disease diagnosis using PCA and bayesian classification rules. Electron. Lett. 45(8), 389–391 (2009)CrossRef Lopez, M., Ramirez, J., Gorriz, J., Salas-Gonzalez, D., Alvarez, I., Segovia, F., Puntonet, C.G.: Automatic tool for Alzheimer’s disease diagnosis using PCA and bayesian classification rules. Electron. Lett. 45(8), 389–391 (2009)CrossRef
16.
Zurück zum Zitat Murray, D.G., McSherry, F., Isaacs, R., Isard, M., Barham, P., Abadi, M.: Naiad: a timely dataflow system. In: Proceedings of the Twenty-Fourth ACM Symposium on Operating Systems Principles, SOSP 2013, pp. 439–455. ACM, New York (2013) Murray, D.G., McSherry, F., Isaacs, R., Isard, M., Barham, P., Abadi, M.: Naiad: a timely dataflow system. In: Proceedings of the Twenty-Fourth ACM Symposium on Operating Systems Principles, SOSP 2013, pp. 439–455. ACM, New York (2013)
17.
Zurück zum Zitat Pedregosa, F., Varoquaux, G., Gramfort, A., Michel, V., Thirion, B., Grisel, O., Blondel, M., Prettenhofer, P., Weiss, R., Dubourg, V., Vanderplas, J., Passos, A., Cournapeau, D., Brucher, M., Perrot, M., Duchesnay, E.: Scikit-learn: machine learning in python. J. Mach. Learn. Res. 12, 2825–2830 (2011)MathSciNetMATH Pedregosa, F., Varoquaux, G., Gramfort, A., Michel, V., Thirion, B., Grisel, O., Blondel, M., Prettenhofer, P., Weiss, R., Dubourg, V., Vanderplas, J., Passos, A., Cournapeau, D., Brucher, M., Perrot, M., Duchesnay, E.: Scikit-learn: machine learning in python. J. Mach. Learn. Res. 12, 2825–2830 (2011)MathSciNetMATH
18.
Zurück zum Zitat Saxena, P., Pavel, D.G., Quintana, J.C., Horwitz, B.: An automatic threshold-based scaling method for enhancing the usefulness of Tc-HMPAO SPECT in the diagnosis of Alzheimer’s disease. In: Wells, W.M., Colchester, A., Delp, S. (eds.) MICCAI 1998. LNCS, vol. 1496, pp. 623–630. Springer, Heidelberg (1998). doi:10.1007/BFb0056248CrossRef Saxena, P., Pavel, D.G., Quintana, J.C., Horwitz, B.: An automatic threshold-based scaling method for enhancing the usefulness of Tc-HMPAO SPECT in the diagnosis of Alzheimer’s disease. In: Wells, W.M., Colchester, A., Delp, S. (eds.) MICCAI 1998. LNCS, vol. 1496, pp. 623–630. Springer, Heidelberg (1998). doi:10.​1007/​BFb0056248CrossRef
19.
Zurück zum Zitat Segovia, F., Górriz, J.M., Ramírez, J., Salas-Gonzalez, D., Álvarez, I., López, M., Chaves, R.: A comparative study of feature extraction methods for the diagnosis of Alzheimer’s disease using the ADNI database. Neurocomputing 75(1), 64–71 (2012)CrossRef Segovia, F., Górriz, J.M., Ramírez, J., Salas-Gonzalez, D., Álvarez, I., López, M., Chaves, R.: A comparative study of feature extraction methods for the diagnosis of Alzheimer’s disease using the ADNI database. Neurocomputing 75(1), 64–71 (2012)CrossRef
20.
Zurück zum Zitat Segovia, F., Bastin, C., Salmon, E., Górriz, J.M., Ramírez, J., Phillips, C.: Combining PET images and neuropsychological test data for automatic diagnosis of Alzheimer’s disease. PLoS ONE 9(2), e88687 (2014)CrossRef Segovia, F., Bastin, C., Salmon, E., Górriz, J.M., Ramírez, J., Phillips, C.: Combining PET images and neuropsychological test data for automatic diagnosis of Alzheimer’s disease. PLoS ONE 9(2), e88687 (2014)CrossRef
21.
Zurück zum Zitat Towey, D.J., Bain, P.G., Nijran, K.S.: Automatic classification of 123I-FP-CIT (DaTSCAN) SPECT images. Nucl. Med. Commun. 32(8), 699–707 (2011)CrossRef Towey, D.J., Bain, P.G., Nijran, K.S.: Automatic classification of 123I-FP-CIT (DaTSCAN) SPECT images. Nucl. Med. Commun. 32(8), 699–707 (2011)CrossRef
22.
Zurück zum Zitat Trambaiolli, L.R., Lorena, A.C., Fraga, F.J., Kanda, P.A.M., Anghinah, R., Nitrini, R.: Improving Alzheimer’s disease diagnosis with machine learning techniques. Clin. EEG Neurosci. 42(3), 160–165 (2011)CrossRef Trambaiolli, L.R., Lorena, A.C., Fraga, F.J., Kanda, P.A.M., Anghinah, R., Nitrini, R.: Improving Alzheimer’s disease diagnosis with machine learning techniques. Clin. EEG Neurosci. 42(3), 160–165 (2011)CrossRef
Metadaten
Titel
Assisting the Diagnosis of Neurodegenerative Disorders Using Principal Component Analysis and TensorFlow
verfasst von
Fermín Segovia
Marcelo García-Pérez
Juan Manuel Górriz
Javier Ramírez
Francisco Jesús Martínez-Murcia
Copyright-Jahr
2017
DOI
https://doi.org/10.1007/978-3-319-47364-2_5