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Über dieses Buch

To comment at length on the importance of the benzodiazepines seems superfluous within the scope of this preface. No other class of active substances has experienced an even approximately compa­ rable advance in the past two decades. It is therefore not surprising that the formerly dominant barbiturates and bromocarbamides have had to give way in many fields to the benzodiazepines, which now rank first (Proudfoot and Park [1828]). Closely linked with the great therapeutic importance of the benzodia­ zepines are analytical problems. Detection and the determination of blood levels can be necessary under therapeutic aspects, for instance in working out optimally effective levels in the treatment of epileptic conditions ("drug monitoring"), but also in connection with questions at issue in toxicology and traffic medicine. A toxicological analysis can be subdivided into the following steps: Detection (identification including screening) Determination (e. g. blood, plasma or serum levels) Interpretation of the analytical results. This book is intended as a contribution to each of these chapters: The part "Analytical Data" (pp.I-122) gives a comprehensive collec­ tion of data, e.g. general and chromatographic data (TLC, GLC) as well as spectra (UV, IR, MS) of 19 commercial preparations, 23 important metabolites and 18 hydrolysis derivatives. Information about biotransformation and the possible formation of aminobenzo­ phenone derivatives is also given. The most important analytical methods are presented in an extensive review on pp.123-204 in order to make it possible to select the optimum method on the basis of the essential data.

Inhaltsverzeichnis

Frontmatter

Formula Index and Melting Points

Formelverzeichnis und Schmelzpunkte
Without Abstract
Harald Schütz

Biotransformation

Major Pathways
Without Abstract
Harald Schütz

Index of Treated Substances

Liste der bearbeiteten Substanzen
Without Abstract
Harald Schütz

Formation of Aminobenzophenones and Other Hydrolysis Products (Survey)

Die Entstehung der Aminobenzophenone und anderer Hydrolyseprodukte
Without Abstract
Harald Schütz

Formation of the Hydrolysis Derivatives

Without Abstract
Harald Schütz

Some Important Data

Einige wichtige Daten
Without Abstract
Harald Schütz

TLC — Data

DC-Daten
Without Abstract
Harald Schütz

GLC — Data

GC-Daten
Abstract
The gas Chromatograph was a Varian Aerograph Series 2100 with a flame-ionization detector; integration was carried out with a Spectra Physics Minigrator and a Varian Aerograph Model 480 respectively. Column: 1,5 m × 2 mm I.D. glass column packed with 3 % 0V-17 or 3 % SE-30 on Chromosorb G AW DMCS (80 – 100 mesh).
Harald Schütz

Infrared- and Mass-Spectra

Without Abstract
Harald Schütz

Ultraviolet-Spectra

Without Abstract
Harald Schütz

Presentation of Analytical Methods

Darstellung der Analysenmethoden
Without Abstract
Harald Schütz

Blood-, Serum- and Plasma-Levels and Other Pharmacokinetic Data from Literature

Blut-, Serum und Plasma-Spiegel und andere pharmakokinetische Daten aus der Literatur
Without Abstract
Harald Schütz

Ranges of Maximum Concentrations After Oral Administration

Bereiche maximaler Konzentration nach oraler Verabreichung
Without Abstract
Harald Schütz

Survey of Benzodiazepine Literature

Übersicht zur Benzodiazepinliteratur
Without Abstract
Harald Schütz

Backmatter

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