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2013 | Buch

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Bio-synthetic Polymer Conjugates

herausgegeben von: Helmut Schlaad

Verlag: Springer Berlin Heidelberg

Buchreihe : Advances in Polymer Science

Enthalten in: Springer Professional "Wirtschaft+Technik" , Springer Professional "Technik"

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Über dieses Buch

Polypeptide-Polymer Conjugates, by Henning Menzel Chemical Strategies for the Synthesis of Protein-Polymer Conjugates, by Björn Jung and Patrick Theato Glycopolymer Conjugates, by Ahmed M. Eissa and Neil R. Cameron DNA-Polymer Conjugates: From Synthesis, Through Complex Formation and Self-assembly to Applications, by Dawid Kedracki, Ilyès Safir, Nidhi Gour, Kien Xuan Ngo and Corinne Vebert-Nardin Synthesis of Terpene-Based Polymers, by Junpeng Zhao and Helmut Schlaad

Inhaltsverzeichnis

Frontmatter

Polypeptide–Polymer Conjugates

Abstract

Conventional block copolymers are able to self-assemble in bulk, resulting in a microphase separation or formation of aggregates in solution. Polypeptides show secondary structure effects and specific non-covalent interactions, which can cause a specific aggregation behavior and result in interesting supramolecular structures. Conjugation of polypeptides with simple synthetic polymers combines these phenomena with the advantages of synthetic polymers like solubility and processability. Various chemical strategies have been developed for conjugating different synthetic polymers with smaller and larger peptides. Here, we emphasize conjugation methods for peptides prepared by solid phase peptide synthesis having a controlled sequence as well as for polypeptides consisting of only one or two amino acids, which can be prepared by polymerization of the corresponding N-carboxyanhydride. By consecutive polymerization using a macroinitiator, block copolymers as conjugates are accessible. Different methods using this approach are highlighted. Furthermore, examples of conjugation of peptides with preformed polymers by “click” chemistry are presented.

Henning Menzel

Chemical Strategies for the Synthesis of Protein–Polymer Conjugates

Abstract

Protein-polymer conjugates have achieved tremendous attention in the last few years. The synergistic combination of properties has led to certain advantages in bio-applications. Over the past few years, numerous chemical strategies have been developed to conjugate different synthetic polymers onto proteins, most of which can be summarized within the scope of click-chemistry. Here we highlight conjugation strategies based on available functional groups present on the synthetic polymer and existing groups of proteins from the natural pool. In particular, the chapter organizes the various possible reactions by classes of functional groups present on protein surfaces, deriving from selected amino acid residues.

Björn Jung, Patrick Theato

Glycopolymer Conjugates

Abstract

This review describes recent developments in the field of glycopolymer (polymer–carbohydrate conjugate) synthesis. The interest in this class of polymers that have a wide range of biological recognition properties has grown rapidly in the last decade due to their application in the areas of biotechnology and medicinal chemistry. Modern synthetic methodologies such as controlled radical polymerization, ionic polymerization, ring-opening polymerization (ROP), ring-opening metathesis polymerization (ROMP) and Click chemistry have recently been proven to be extremely efficient and versatile tools for building tailor-made functional polymers with different molecular architectures. The use of these synthetic methods to prepare glycopolymer conjugates is outlined and discussed in detail. The self-assembling behavior of these glycopolymer designs and their interactions with their corresponding lectins (cell surface receptor proteins) are also presented in this review.

Ahmed M. Eissa, Neil R. Cameron

DNA–Polymer Conjugates: From Synthesis, Through Complex Formation and Self-assembly to Applications

Abstract

With this review, we aim at achieving a comprehensive and up to date look at the broad topic of DNA conjugates as well as summarizing the important trends in the particular field of materials based on nucleic acids.

Dawid Kedracki, Ilyès Safir, Nidhi Gour, Kien Xuan Ngo, Corinne Vebert-Nardin

Synthesis of Terpene-Based Polymers

Abstract

Terpenes or terpenoids are a large class of diverse biological compounds derived from isoprene. Due to their abundance in nature and desirable properties, there has been great interest in producing polymers with terpenes as either functional entities or as the main constituent. Terpene-based polymers have found applications as biomedical or liquid crystalline materials and, more importantly, have greatly contributed to the concept of sustainable polymer chemistry. The design and preparation of terpene-based polymers have involved different chemical strategies and a wide variety of polymerization techniques, making use of the chemical functionalities in terpene molecules, e.g. (conjugated) double bonds, hydroxyl and carboxyl groups. This review describes the synthetic methodologies for terpene-based polymers, classified by the position of terpene entities in the polymer chains, i.e., main chain, terminal or central group, and pendant group.

Junpeng Zhao, Helmut Schlaad

Backmatter

Titel: Bio-synthetic Polymer Conjugates
herausgegeben von: Helmut Schlaad
Verlag: Springer Berlin Heidelberg
Electronic ISBN: 978-3-642-34350-6
Print ISBN: 978-3-642-34349-0
DOI: https://doi.org/10.1007/978-3-642-34350-6

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