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2013 | OriginalPaper | Buchkapitel

Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery

verfasst von : Zengyou He, Robert Z. Qi, Weichuan Yu

Erschienen in: Applications of MALDI-TOF Spectroscopy

Verlag: Springer Berlin Heidelberg

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Abstract

In this chapter we first describe the applications of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) in biomarker discovery. After a summary of the general analysis pipeline of MALDI MS data, each step of the pipeline will be elaborated in detail. In particular we try to provide a categorization of existing solutions with the hope that the reader can obtain a global picture on this topic. In addition we show how to apply such an analysis pipeline in protein and glycan profiling for biomarker discovery and for a deeper understanding of diseases. Finally we discuss the limitations of current analysis methods and the perspectives of future research.

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Titel: Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery
verfasst von: Zengyou He
Robert Z. Qi
Weichuan Yu
Verlag: Springer Berlin Heidelberg
Buch: Applications of MALDI-TOF Spectroscopy
Print ISBN: 978-3-642-35664-3

Electronic ISBN: 978-3-642-35665-0

Copyright-Jahr: 2013
DOI: https://doi.org/10.1007/128_2012_365