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2014 | OriginalPaper | Buchkapitel

32. Bioinformatics and Nanotechnologies: Nanomedicine

verfasst von : Federico Ambrogi, Danila Coradini, Niccolò Bassani, Patrizia Boracchi, Elia M. Biganzoli

Erschienen in: Springer Handbook of Bio-/Neuroinformatics

Verlag: Springer Berlin Heidelberg

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Abstract

In this chapter we focus on the bioinformatics strategies for translating genome-wide expression analyses into clinically useful cancer markers with a specific focus on breast cancer with a perspective on new diagnostic device tools coming from the field of nanobiotechnology and the challenges related to high-throughput data integration, analysis, and assessment from multiple sources.

Great progress in the development of molecular biology techniques has been seen since the discovery of the structure of deoxyribonucleic acid (DNA) and the implementation of a polymerase chain reaction (PCR) method. This started a new era of research on the structure of nucleic acids molecules, the development of new analytical tools, and DNA-based analyses that allowed the sequencing of the human genome, the completion of which has led to intensified efforts toward comprehensive analysis of mammalian cell struc ture and metabolism in order to better understand the mechanisms that regulate normal cell behavior and identify the gene alterations responsible for a broad spectrum of human diseases, such as cancer, diabetes, cardiovascular diseases, neurodegenerative disorders, and others.

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Titel: Bioinformatics and Nanotechnologies: Nanomedicine
verfasst von: Federico Ambrogi
Danila Coradini
Niccolò Bassani
Patrizia Boracchi
Elia M. Biganzoli
Verlag: Springer Berlin Heidelberg
Buch: Springer Handbook of Bio-/Neuroinformatics
Print ISBN: 978-3-642-30573-3

Electronic ISBN: 978-3-642-30574-0

Copyright-Jahr: 2014
DOI: https://doi.org/10.1007/978-3-642-30574-0_32

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