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Polymer Bulletin
Erschienen in: Polymer Bulletin 12/2017

05.04.2017 | Original Paper

Biological properties and enzymatic degradation studies of clindamycin-loaded PLA/HAp microspheres prepared from crocodile bones

verfasst von: Juntima Pradid, Wirunya Keawwatana, Upsorn Boonyang, Siree Tangbunsuk

Erschienen in: Polymer Bulletin | Ausgabe 12/2017

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Abstract

Polylactic acid (PLA)/hydroxyapatite (HAp) biocomposite microspheres with a specific core–shell structure for application as drug carriers were synthesised using an ultrasound field. In addition, the loading efficiency of clindamycin phosphate increased when the HAp content was increased to 30%. The effect of HAp content on enzymatic degradation of PLA/HAp microspheres loaded with clindamycin phosphate was that the degradation rate increased with increasing HAp content. Apatite formed on the surfaces of the PLA and PLA/HAp microsphere loading of clindamycin phosphate showed Ca and P peaks in energy-dispersive X-ray spectroscopy (EDX) data. In addition, the PLA and PLA/HAp microspheres loaded with clindamycin phosphate did not show any cytotoxicity against the human lung fibroblast MRC-5.
Vorheriger Artikel Real-time polymerization monitoring in a dual-cured resin cement by magnetic resonance
Nächster Artikel Novel sulfonated poly(glycidyl methacrylate) grafted Nafion membranes for fuel cell applications

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Literatur
1.
Yu D, Wong J, Matsuda Y, Fox JL, Higuchi WI, Otsuka M (1992) Self-setting hydroxyapatite cement: a novel skeletal drug-delivery system for antibiotics. J Pharm Sci 81(6):529–532CrossRef
2.
Yang L-X, Yin J-J, Wang L-L, Xing G-X, Ying P, Liu Q-W (2012) Hydrothermal synthesis of hierarchical hydroxyapatite: preparation, growth mechanism and drug release property. Ceram Int 38:495–502CrossRef
3.
Tomoda K, Ariizumi H, Nakaji T, Makino K (2010) Hydroxyapatite particles as drug carriers for proteins. Coll Surf B 76:226–235CrossRef
4.
Palazzo B, Sidoti MC, Roveri N, Tampieri A, Sandri M, Bertolazzi L, Galbusera F, Dubini G, Vena P, Contro R (2005) Controlled drug delivery from porous hydroxyapatite grafts: an experimental and theoretical approach. Mater Sci Eng C 25:207–213CrossRef
5.
Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI (1994) A novel skeletal drug delivery system using a self-setting calcium phosphate cement. 5. Drug release behavior from a heterogenous drug-loaded cement containing ananticancer drug. J Pharm Sci 83(11):1565–1568CrossRef
6.
Oner M, Yetiz E, Ay E, Uysal U (2011) Ibuprofen release from porous hydroxyapatite tablets. Ceram Int 37:2117–2125CrossRef
7.
Deirmengian CA, Lonner JH (2012) What’s new in adult reconstructive knee surgery. J Bone Joint Surg Inc 94:181–188CrossRef
8.
Vukomanović M, Škapin I, Žagar E, Kralj B, Ignjatović N, Uskoković D (2011) Poly(D, L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: simultaneous release of a drug and a prodrug (clindamycin and clindamycinphosphate). Coll Surf B 82:414–421CrossRef
9.
Vukomanović M, Skapin SD, Jančar B, Maksin T, Ignjatović N, Uskoković V, Uskoković D (2011) Poly(d, l-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: a multifunctional system for controlled drug delivery. Colloids Surf B: Biointerfaces 82:404–413CrossRef
10.
Ige OO, Umoru LE, Aribo S (2012) Natural products: a minefield of biomaterials. ISRN Mater Sci 2012:1–20CrossRef
11.
Murugan R, Ramakrishna S (2005) Development of nanocomposites for bone grafting. Compos Sci Technol 65:2385–2406CrossRef
12.
Gaharwar KA, Schexnailder PJ, Schmidt G (2011) Nanobiomaterials Handbook Taylor and Francis Group, LLC
13.
Rasal RM, Janorkar AV, Hirt DE (2010) Poly(lactic acid) modifications. Prog Polym Sci 35:338–356CrossRef
14.
Spinu M, Jackson C, Keating MY, Gardner KH (1996) Material design in poly(lactic acid) systems: block copolymers, star homo- and copolymers and stereocomplexs. Pure Appl Chem A33(10):1497–1530
15.
Smieja M (1998) Current indications for the use of clindamycin: a critical review. Can J Infect Dis 9(1):22–28CrossRef
16.
O’Grady F, Finch RG, Lambert HP, Greenwood D (1997) Antibiotic and chemotherapy: anti-infective agents and their use in therapy. Elsevier, UK
17.
Darley ESR (2004) Antibiotic treatment of Gram-positive bone and joint infections. J Antimicrob Chemoth 53(6):928–935CrossRef
18.
Kokubo T, Takadama H (2006) How useful is SBF in predicting in vivo bone bioactivity. Biomaterials 27:2907–2915CrossRef
19.
Pradid JKW, Tangbunsuk S (2014) Study the Effect of HAp content in PLA/HAp microphere on the efficiency of drug (Clindamycin) loading process. Adv Mat Res 834–836:559–562
20.
Jevti´c M, Radulovic´ A, Ignjatovic´ N, Mitric´ M, Uskokovic´ D (2009) Controlled assembly of poly(D, L-lactide-co-glycolide)/hydroxyapatitecore–shell nanospheres under ultrasonic irradiation. Acta Biomater 5:208–218CrossRef
21.
Jafari S, Maleki-Dizaji N, Barar J, Barzegar-Jalali M, Rameshrad M, Adibkia K (2016) Methylprednisolone acetate-loaded hydroxyapatite nanoparticles as a potential drug delivery system for treatment of rheumatoid arthritis: in vitro and in vivo evaluations. Eur J Pharm Sci 91:225–235CrossRef
22.
Ignjatovic NL, Penov-Gasi KM, Wu VM, Ajdukovic JJ, Kojic VV, Vasiljevic-Radovic D, Kuzmanovic M, Uskokovic V, Uskokovic DP (2016) Selective anticancer activity of hydroxyapatite/chitosan-poly(d, l)-lactide-co-glycolide particles loaded with an androstane-based cancer inhibitor. Coll Surf B Biointerfaces 148:629–639CrossRef
23.
Guo Y, Shi X, Fang Q, Zhang J, Fang H, Jia W, Yang G, Yang L (2014) Facile preparation of hydroxyapatite–chondroitin sulfate hybrid mesoporous microrods for controlled and sustained release of antitumor drugs. Mater Lett 125:111–115CrossRef
24.
Pistner H, Bendix DR, Muhling J, Reuther JF (1993) Poly(L-lactide): a long-term degradation study in vivo Part III. Analytical characterization. Biomaterials 14:291–304CrossRef
25.
Li S, Tenon M, Garreau H, Braud C, Vert M (2000) Enzymatic degradation of stereocopolymers derived from l-, dl- and meso-lactides. Polym Degrad Stab 67:85–90CrossRef
26.
Lin PL, Fang HW, Tseng T, Lee WH (2007) Effects of hydroxyapatite dosage on mechanical and biological behaviors of polylactic acid composite materials. Mater Lett 61:3009–3013CrossRef
27.
Wong KL, Wong CT, Liu WC, Pan HB, Fong MK, Lam WM, Cheung WL, Tang WM, Chiu KY, Luk KDK, Lu WW (2009) Mechanical properties andin vitro response of strontium-containinghydroxyapatite/polyetheretherketone composites. Biomaterials 30:3810–3817CrossRef
28.
Kim HM, Himeno T, Kokubo T, Nakamura T (2005) Process and kinetics of bonelike apatite formation on sinteredhydroxyapatite in a simulated body fluid. Biomaterials 26:4366–4373CrossRef
29.
Iqbal N, Kadir MRA, Mahmood NH, Salim N, Froemming GRA, Balaji HR, Kamarul T (2013) Characterization, antibacterial andin vitro compatibilityof zinc–silver doped hydroxyapatite nanoparticles preparedthrough microwave synthesis. Ceram Int 40:4507–4513CrossRef
30.
Ramana Ramya J, Thanigai Arul K, Elayaraja K, Narayana Kalkura S (2014) Physicochemical and biological properties of iron and zinc ions co-doped nanocrystalline hydroxyapatite, synthesized by ultrasonication. Ceram Int 40(10):16707–16717CrossRef
31.
Thanigai Arul K, Ramana Ramya J, Bhalerao GM, Narayana Kalkura S (2014) Physicochemical characterization of the superhydrophilic, magnesium and silver ions co-incorporated nanocrystalline hydroxyapatite, synthesized by microwave processing. Ceram Int 40:13771–13779CrossRef
32.
Thanigaiarul K, Elayaraja K, Magudapathy P, Kamachi MU, Nair KGM, Sudarshan M, Krishna JBM, Chakraborty A, Narayana Kalkura S (2013) Surface modification of nanocrystalline calcium phosphate bioceramic by low energy nitrogen ion implantation. Ceram Int 39(3):3027–3034CrossRef
33.
Athanasiou KA, Gabriele GN, Agrawal CM (1996) Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials 17:93–102CrossRef
Metadaten
Titel
Biological properties and enzymatic degradation studies of clindamycin-loaded PLA/HAp microspheres prepared from crocodile bones
verfasst von
Juntima Pradid
Wirunya Keawwatana
Upsorn Boonyang
Siree Tangbunsuk
Publikationsdatum
05.04.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 12/2017
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-017-2006-2

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