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Erschienen in:
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2011 | OriginalPaper | Buchkapitel

3. Biomedical Integrated Instrumentation

verfasst von : Jordi Colomer-Farrarons, Pere Lluís Miribel-Català

Erschienen in: A CMOS Self-Powered Front-End Architecture for Subcutaneous Event-Detector Devices

Verlag: Springer Netherlands

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Abstract

This Chapter is focused on the development of an integrated instrumentation to work with three electrodes amperometric Biosensor. First of all, it is introduced the conception of three electrodes configuration and how it works. Moreover, some typical electrochemical techniques like Voltammetry, EIS and amperometry, are introduced to the reader. The instrumentation electronics is based on a potentiostat architecture, which is explained in detail and experimentally validated. The obtained results with the full-custom approach are compared with the ones obtained using a commercial potentiostat. In that way, the correct operation of the designed circuits is fully validated. Furthermore, this chapter explains the conception of a Lock-In amplifier circuit used to detect the real and imaginary components of the complex impedance measured from the Biosensor. This circuit is theoretically explained and some simulated results are shown. Finally, the conception of Biotelemetry or how to transmit information from the subcutaneous device to the external reader is introduced. Then, the implemented protocol in this work is detailed. In summary, this chapter presents the developed BioChip IC that is able to drive the sensor, process the measured data and transmit the data to the external side through an inductive link.

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Vorheriges Kapitel Energy Harvesting (Multi Harvesting Power Chip)
Nächstes Kapitel CMOS Front-End Architecture for In-vivo Biomedical Subcutaneous Detection Devices
Literatur
1.
P.H. King, R.C. Fries, Design of Biomedical Devices and Systems, 2nd edn. (CRC Press, Florida, USA, 2009), ISBN: 978-1-4200-6179-6
2.
J.G. Webster, Medical Instrumentation Application and Design, 3rd edn. (Wiley, New York, USA, 1998), ISBN: 0-471-15368-0
3.
R.P. Areny, Sensores y Acondicionadores de Señal. 3ª Edición, (Marcombo, Barcelona, Spain, 1998), ISBN 84-267-1171-5
4.
C. Wen-Yaw, P. Arnold, W. Ying-Hsiang, T. Tseng, A 600 μW Readout Circuit with Potentiostat for Amperometric Chemical Sensors and Glucose Meter Applications, IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC 2007, 20–22 (2007)
5.
F.Z. Padmadinata, J.J. Veerhoek, G.J.A. van Dijk, J.H. Huijsing, Microelectronic skin electrode. Sens. Actuators B Chem. 1(1–6), 491–494 (1990)CrossRef
6.
7.
S.K. Kailasa, S.H. Kang, Microchip-based capillary electrophoresis for DNA analysis in modern biotechnology: A review, Taylor. Francis. Sep. Purif. Rev. 38, 242–288 (2009)CrossRef
8.
V.M. Ivama, S.H.P. Serrano, Rhodium – Prussian Blue modified carbon paste electrode (Rh – PBMCPE) for amperometric detection of0020hydrogen peroxide. J. Brazilin. Chem. Soc. 14(4), (Aug 2003). ISSN: 0103–5053
9.
X. Ji, C.E. Banks, A. Crossley, R.G. Compton, Oxygenated edge plane sites slow the electron transfer of the ferro-/ferricyanide redox couple at graphite electrodes. Chem. Phys. Chem. 7, 1337–1344 (2006)CrossRef
10.
F. Heer et al., CMOS microelectrode array for the monitoring of electrogenic cells. Biosens. Bioelecron 20, 358–366 (2004)CrossRef
11.
S.M. Radke, E.C. Alocilja, A microfabricated biosensor for detecting foodborne bioterrorism agents. IEEE Sens. J. 5(4), 744–750 (2005)CrossRef
12.
D.L. McCulloch, G.B. Boemel, M.S. Borchert, Comparison of contact lens, foil, fiber, and skin electrodes for patterns electroretinograms. Doc. Ophtalmol 94, 4 (1997)CrossRef
13.
O. Chailapakul, J. Promnil, M. Somasundrum, M. Tanticharoen, Immobilized K3Fe(CN)6 and glucose oxidase in polypyrrole on a gold micro-electrode and the it application as a glucose sensor. J. Sci. Res. Chula. Unit. 25, 1 (2006)
14.
S.V. Dzyadevych et al., Electrochem. Enzyme. Biosens. (2006). ISBN: 966-02-4200-X
15.
F. Mizutani, E. Yamanaka, Y. Tanabe, K. Tsuda, An enzyme electrode for L-lactate with chemically amplified electrode. Anal. Chem. Acta. 117, 153–166 (1985)CrossRef
16.
P.N. Bartlett, R.G. Whitaker, Strategies for the development of amperometric enzyme electrodes. Biosensors 3, 359–379 (1987)CrossRef
17.
L.E. Morrison, Time resolved detection of energy transfer: Theory and application to immunoassays. Anal. Biochem. 174, 101–120 (1988)CrossRef
18.
H.A. Lee, M.R.A. Morgan, Food immunoassay: Application of polyclonal, monoclonal and remobinant antibodies. Trends Food Sci. Technol. 3, 129–134 (1993)
19.
C. Dumschat et al., Pesticide-sensitive ISFET based on enzyme inhibition. Anal. Chim. Acta. 252, 7–9 (1991)CrossRef
20.
P. Bergveld, Thirty years of ISFETOLOGY. What happened in the past 30 years and what may happen in the next 30 years. Sens. Actuators B 88, 1–20 (2003)CrossRef
21.
E. Lorenzo et al., Analytical strategies for amperometric biosensors based on chemically modified electrodes. Biosens. Bioelectron 13, 319–332 (1998)CrossRef
22.
D.B. Kell, C.L. Dave, Conductimetric and Impediometric Devices in Biosensors. A Practical Approach, (IRL Press, Oxford, 1990)
23.
D.C. Cullen et al., Multi-analyte miniature conductance biosensor. Anal. Chim. Acta. 231, 33–40 (1990)CrossRef
24.
J. Colomer-Farrarons, P. Miribel-Català, A. Saiz-Vela, J. Samitier, in Proceeding of the 16th IEEE International Conference on Very Large Scale Integration VLSI – SOC, A 50 μW low-voltage CMOS Biopotentiostat for low frequency Capacitive Biosensor, 2008
25.
A. Gore, S. Chakrabartty, S. Pal, E. Alocilja, A multi-channel femtoampere-sensitivity conductometric array for biosensing applications. IEEE Transactions on Circuits and Systems I: Regular Papers, 53(11), 2357–2363 (2006)
26.
L.Y. Woo, L.P. Martin, R. Glass, R.J. Gorte. Impedance characterization of a model Au/Yttria-Stabilized Zirconia/Au electrochemical cell in variying oxygen and NOx concentrations. J. Electrochem. Soc. 154(4), 129–135 (2007)CrossRef
27.
J.M. Flores, R.D. Romero, J.G. Llongueras, Espectroscopía de impedancia electroquímica en corrosión, Instituto Mexicano del Petróleo, UNAM, Available at: depa.pquim.unam.mx/labcorr/libro/Manual-EIS-IMP-UNAM.PDF
28.
A. Lasia. Electrochemical Impedance Spectroscopy and Its Applications. Modern Aspects of Electrochemistry, vol. 32. (Kluwer Academic/Plenum Publisher, New York, USA, 1999), Chapter 2, p. 143
29.
R.J. Reay, S.P. Kounaves, G.T.A. Kovacs, An integrated CMOS potentiostat for miniaturized electroanalytical instrumentation, IEEE International 41st ISSCC Solid-State Circuits Conference, pp. 162–163 (1994)
30.
C. Berggren, B. Bjarnason, G. Johansson, Capacitive biosensors, Electroanalysis 13(3), 173–180 (2001)CrossRef
31.
S. Grimnes, O.G. Martinsen, Bioimpedance and Bioelectricity Basics, 2nd edn. (Academic Press, Elseiver, London, UK, 2008). ISBN: 0-12-303260-1
32.
33.
34.
C.G. Zoski, Handbook of Electrochemistery, (Elsevier, The Netherlands, 2007), ISBN: 0-444-51958-0
35.
36.
37.
J. Braz, Rhodium–prussian blue modified carbon paste electrode (Rh-PBMCPE) for amperometric detection of hydrogen peroxide. J. Brazilian Chem. Soc. 14, 4 (2003). ISSN 0103–5053
38.
A.J. Bard, L.R. Faulkner, Electrochemical Methods. Fundamentals and Applications, 2nd edn. (Wiley, New York, NY, 2001). ISBN 0-471-04372-9
39.
S.M. Martin, F.H. Gebara, T.D. Strong, R.B. Brown, A low.voltage, chemical sensor interface for system-on-chip: The fully-differential potentiostat, Proceeding of the 2004 International Symposium on Circuits and Systeems ISCAS’02, vol. 4, pp. IV–892–895, (2004)
40.
E. Lauwers, J. Suls, W. Gumbrecht, D. Maes, G. Gielen, W. Sansen, A CMOS multiparameter biochemical microsensor with temperature control and signal interfacing. IEEE J. Solid-State Circuits 36, 12 (2001)CrossRef
41.
S.M.R. Hasan, Stability analysis and novel compensation of a CMOS current-feedback potentiostat circuit for electrochemical sensors. Sens. J. IEEE. 7(5), 814–824 (May 2007)CrossRef
42.
J. Colomer-Farrarons, P. Miribel-Català, A. Saiz-Vela, I. Rodriguez, J. Samitier, in Proceedings of the IEEE MWSCAS Conference, A low power CMOS Biopotentiostat in a Low-Voltage 0.13 μm Digital technology, Cancún, Mexico, 2009
43.
J. Colomer-Farrarons, P. Miribel-Català, I. Rodriguez, J. Samitier, in Proceedings of the XX IECON Conference, CMOS Front-end Architecture for In-Vivo Biomedical Implantable devices, Porto, Portugal, 2009
44.
J. Colomer-Farrarons, P. Miribel-Català, A. Saiz-Vela, M. Puig, J. Samitier, A. Errachid, A 50 μW low-voltage CMOS Biopotentiostat for low-frequenciy Capacitive Biosensor, Proceedings of the XX IEEE VLSI Conference, Rhodes, Greece, 2008
45.
S.M. Martin, F.H. Gebara, B.J. Larivee, R.B. Brown, A CMOS-integrated microinstrument for trace detection of heavy metals. IEEE J. Solid-State Circuits 40(12), 2777–2786 (2005)CrossRef
46.
T.D. Strong, S.M. Martin, R.F. Franklin, R.B. Brown, in Proceedings of the IEEE International Symposium on Circuits and Systems, Integrated electrochemical neurosensors, 2006, pp. 4110–4113
47.
R. Jacob Baker, CMOS: Circuit Design, Layout, and Simulation, Revised 2nd edn. (Wiley – Interscience, NJ, USA, 2008). ISBN 978–0-470-22941-5
48.
R. Gregorian, Introduction to CMOS Op-Amps and Comparators, (Wiley, New York, USA, 1999). ISBN 0-471-31778-0
49.
J.H. Huijsing, Operational Amplifiers, Theory and Design, (Kluwer Academic Publishers, Dordrecht, The Netherlands, 2001). ISBN: 0-7923-7284-0
50.
F. Maloberti, Analog Design for CMOS VLSI Systems, (Kluwer Academic Publishers, The Netherlands, 2001). ISBN: 0-7923-7550-5
51.
A.C. Patil, F. Xiao, M. Mehregany, S.L. Garverick, Fully-monolithic, 600°C differential amplifier in 6H-SiC JFET IC technology, Custom Integrated Circuits Conference, CICC’09, pp. 73–76, (2009)
52.
J.P. Close, F. Santos, in Proceeding of the Bipolar/BiCMOS Circuits and Technology Meeting. A JFET input single supply operational amplifier with rail-to-rail output, pp. 149–152, (1993)
53.
F. Serra-Graells, A. Rueda, J.L. Huertas, Low-Voltage CMOS Log Companding Analog Design, (Springer, Netherlands, 2003). ISBN: 978-1-4020-7445-5
54.
R.J. Baker, CMOS: Mixed-Signal Circuit Design, 2nd edn. (Wiley – IEEE Press Series on Microelectronic Systems, NJ, USA, 2008). ISBN: 978-0-470-29026-2
55.
56.
X. Gan, Y. Wu, L. Liu, W. Hu, Effects of K4Fe(CN)6 on electroless copper plating using hypophospite as reducing agent. J. Appl. Electrochem. 37, 899–904 (Springer, Apr 2007)
57.
58.
59.
N.I. Bojorge Ramírez, M.Fortes, A.M. Salgado, B. Valdman, Construction of an Amperometric Immunosensor Using Solanum Tuberosum Potato Apyrase for the Detection of Schistosomiasis. Información Tecnológica 20, 3 (2009). ISSN: 0718–0764
60.
K.K. Kasem, S. Jones, Platinum as a reference electrode in electrochemical measurements, Platinum Metal Rev. 52, 100–106 (Apr 2008)CrossRef
61.
H.E.A. Ferreira, D. Daniel, M. Bertotti, E.M. Richter, A novel disposable electrochemical microcell construction and characterization, J. Brazilian Chem. Soc. 19, 8 (2008)CrossRef
62.
I. Bontidean, C. Berggren, G. Johansson, E. Csöregi, B. Mattiasson, J.R. Lloyd, K.J. Jakeman, N.L. Brown, Detection of heavy metal ions at femtomolar levels using protein-based biosensors. Anal. Chem. 70(19), 4162–4169 (1998)CrossRef
63.
E. Katz, I. Willner, Probing biomolecular interactions at conductive and semiconductive surfaces by impedance spectroscopy:Routes to impedimetric immunosensors, DNA-sensors, and enzyme biosensors, Electroanalysis 15(11), 913–947 (2003)
64.
L. Yang, Y. Li, C.L. Griffis, M.G. Johnson, Interdigitated microelectrode (IME) impedance sensor for the detection of ciable Salmonella typhimurium, Biosens. Bioelectron 19, (10), 1139–1147 (2004)CrossRef
65.
B. Robert, C. Northrop, in Analysis and Application of Analog Electronic Circuits to Biomedical Instrumentation, ed. by M.R. Neuman. The Biomedical Engineering Series (CRC Press, Florida, USA, 2004)
66.
A. De Marcellis, G. Ferri, M. Patrizi, V. Stornelli, A.D’ Amico, C. Di Natale, E. Martinelli, A. Alimelli, R. Paolesse, An integrated analog lock-in amplifier for low-voltage low-frequency sensor interface, in Proceddings of the Interational Workshop on Advances in Sensors and Interface, IWASI, pp. 1–5 June 2007
67.
D. Rairigh, A. Mason, C. Yang, Analysis of on-chip impedance spectroscopy methodologies for sensor arrays. Sensor. Lett. 4(4), 398–402 (2006)CrossRef
68.
A.E. Moe, S.R. Marx, I. Bhinderwala, D.M. Wilson, A miniaturuzed lock-in amplifier design suitable for impedance measurements in cells. Proc. IEEE Sens. 1(24–27), 215–218 (AUTRICHE 2004)
69.
W. Xu, E.G. Friedman, Clock Feedthrough in CMOS analog transmission gate switches. Anal. Int. Circuits and Signal Process 44, 271–281 (2005)CrossRef
70.
R. Hogervost, J.P. Tero, R.G.H. Eschauzier, J.H. Huijsin. A compact power-efficient 3 V CMOS rail-to-rail input/ouput omperational amplifier for VLSI cell libraries. IEEE J. Solid-State Circuits 29, 1505–1513 (1994)CrossRef
71.
A. Veeravalli, E. Sánchez-Sinencio. J. Silva-Martínez, Transconductance amplifiers with very small transconductances: A comparative design approach. IEEE J. Solid-State Circuits 37(6), 770–775 (June 2002)CrossRef
72.
A. Arnaud, R. Fiorelli, C. Galup-Montoro, Nanowatt, sub-nS OTAs, with Sub-10-mV input offset, using series-parallel current mirrors. IEEE J. Solid-State Circuits 41(9), 2009–2018 (Sept 2006)CrossRef
73.
J.M. Fiore, in Amplificadores Operacionales y Circuitos Integrados Lineales, ed. by Thomson. (Mohawk Valley Community College, Ed. Paraninfo, Madrid, Spain, 2002)
74.
R.S. Machay, Bio–Medical Telemetry, 2nd edn. (Wiley, New York, NY, 1970)
75.
H.P. Kimmich, in Biotelemetry, eds. by J.G. Webster. Encyclopedia of Medical Devices and Instrumentation, (Wiley, New York, NY, 1980)
76.
A. Santic, M.R. Neuman, A low-power infrared biotelemetry system, Biotelemetry VIII, (Kimmich/Klewe, Netherlands, 1984)
77.
S.A.P. Haddad, W.A. Serdijn, Ultra low-power biomedical signal processing: An analog wavelet filter approach for pacemakers, Anal. Circuits and Signal Process. (Springer 2009). ISBN: 978-1-4020-9072-1
78.
M.R. Haider, S.K. Islam, M. Zhang, A low-power signal processing unit for in vivo monioring and transmission of sensor signals. Sens. Trans. J. 84(10), 1625–1632 (2007)
79.
80.
K. Van Schuylengergh, R. Puers, Inductive Powering. Basic Theory and Application to Biomedical Systems, (Springer, The Netherlands, 2009). ISBN: 978-90-481-2411-4
81.
B. Lenaerts, R. Puers, Omnidirectional Inductive Powering for Biomedical Implants, (Springer, The Netherlands, 2009). ISBN: 978-1-4020-9074-5
82.
W.C. Lin, S.K. Pillay, A micropower pulsewidht-modulation-pulse-position-modulation two-channel telemetry system for biomedical applications. IEEE Trans. Biomed. Eng. BME – 21, 273–280 (1974)CrossRef
83.
C. Weller, Electrocardiography by infrared telemetry. J. Physiol. (London) 267, 11–12 (1977)ADS
84.
Z. Tang, B. Smith, J.H. Schild, P.H. Peckham, Data transmission from an implantable biotelemeter by load-shift keying using circuit configuration modulator. IEEE Trans. Biomed. Eng. BME-42, 524–528 (1995)CrossRef
85.
A. Santic, M.R. Neuman, A low-power infrared biotelemetry system, Biotelemetry VIII, (Kimmich/Klewe, Netherlands, 1984)
86.
H.P. Kimmich, Biotelemetry, Enciclopedia of Medical Devices and Instrumentation, (Willey, New York, USA, 1988), pp. 409–425
87.
88.
D. Gajski, Principios de Diseño Digital, (Prentice Hall, Madrid, España, 2000). ISBN: 84-8322-004-0
Metadaten
Titel
Biomedical Integrated Instrumentation
verfasst von
Jordi Colomer-Farrarons
Pere Lluís Miribel-Català
Copyright-Jahr
2011
Verlag
Springer Netherlands
Buch
A CMOS Self-Powered Front-End Architecture for Subcutaneous Event-Detector Devices

Print ISBN: 978-94-007-0685-9

Electronic ISBN: 978-94-007-0686-6

Copyright-Jahr: 2011

DOI
https://doi.org/10.1007/978-94-007-0686-6_3

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