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Journal of Sol-Gel Science and Technology

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21.05.2022 | Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications

Bone formation with high bacterial inhibition and low toxicity behavior by melding of Al₂O₃ on nanobioactive glass ceramics via sol-gel process

verfasst von: M. S. Kairon Mubina, S. Shailajha, R. Sankaranarayanan, M. Iyyadurai

Erschienen in: Journal of Sol-Gel Science and Technology | Ausgabe 1/2022

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Abstract

Bioactive glasses have been popular as coating materials on bone implants in recent years to increase their integration with the host tissue and overall biological function. Infection and toxicity are significant factors in the failure of bone-implant material. The goal of this research is to develop a sol-gel derived, Al₂O₃ doped nanobioactive glass-ceramics (nBGC) with non-toxic and antibacterial activity. The main crystalline phase of sodium calcium silicate was transformed to sodium calcium aluminium silicate by increasing the Al₂O₃ concentration, it was confirmed by X-ray diffraction (XRD) and Fourier Transform Infra-Red (FTIR) spectroscopy analysis. The density and mechanical strength were increased as 2.63–3.12 g/cm³ and 75–105 MPa, respectively for the sample x = 0 to 10 wt.%. The formation of hydroxyapatite (HAp) was proved by XRD, FTIR, and FESEM (Field Emission Scanning Electron Microscope) with EDS (Energy Dispersive X-ray Spectroscopy) analysis through variations in pH, zeta potential, and degradation behavior. Higher cell viability percentage was attained as >99% for L929 cells, outstanding antibacterial activity against E. coli and S. aureus and excellent hydrophilic nature were obtained for the sample nBGC-10Al. Altogether, a higher concentration of Al₂O₃ in nBGC could enhance the physical and biological properties and it can be used as an excellent candidate for orthopedic applications.

Vorheriger Artikel Preparation and properties of pH-responsive magnetic mesoporous silica drug carrier

Nächster Artikel Preparation and activity evaluation of B4C/ZnO composite photocatalyst

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Titel: Bone formation with high bacterial inhibition and low toxicity behavior by melding of Al2O3 on nanobioactive glass ceramics via sol-gel process
verfasst von: M. S. Kairon Mubina
S. Shailajha
R. Sankaranarayanan
M. Iyyadurai
Publikationsdatum: 21.05.2022
Verlag: Springer US
Erschienen in: Journal of Sol-Gel Science and Technology / Ausgabe 1/2022
Print ISSN: 0928-0707
Elektronische ISSN: 1573-4846
DOI: https://doi.org/10.1007/s10971-022-05842-9

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