Skip to main content

2014 | OriginalPaper | Buchkapitel

Can Distance Measures Based on Lempel-Ziv Complexity Help in the Detection of Alzheimer’s Disease from Electroencephalograms?

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

This pilot study applied three distance-based bivariate Lempel-Ziv complexity (LZC) measures to investigate the changes in electroencephalogram (EEG) signals between 11 patients with Alzheimer’s disease (AD) and 11 age matched controls. These methods measure richness of complexity between pairs of signals. Complexity of control subjects’ EEGs was richer, i.e. signals were made from a greater number and greater range of subsequences, than those from AD patients in almost all cases in two non-normalized distance-based methods. Only some pairs including electrode T4 (2.1% of the total) occasionally showed the reverse result. Statistically significant differences were found with these two methods in 21 and 18 of 120 tested electrode pairs, respectively (Student’s t test, p<0.01). Receiver operating curves were used to calculate the sensitivity (number of correctly classified AD patients) and specificity (number of correctly classified controls). Accuracy is the combined correct classification of controls and AD patients. The maximum sensitivity found was 100%, specificity 90.9% and accuracy 86.4% at various electrode pairs with both non-normalized methods. The normalized method showed many electrode pairs with increased richness of complexity for AD patients than controls (67.5% of the total). It was found that this was due to the normalization procedure modifying the distribution of the original complexities from the electrode pairs. These findings suggest non-normalized distance-based bivariate LZC measures can be reliably applied to complex physiological signals such as human EEGs to further understand the effect of AD on the complexity of brain signals of patients. However, care must be taken when normalization procedures are applied.

.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Metadaten
Titel
Can Distance Measures Based on Lempel-Ziv Complexity Help in the Detection of Alzheimer’s Disease from Electroencephalograms?
verfasst von
S. Simons
D. Abásolo
Copyright-Jahr
2014
DOI
https://doi.org/10.1007/978-3-319-00846-2_173