Weitere Artikel dieser Ausgabe durch Wischen aufrufen
To assess the predictive value for local tumor progression (LTP) of geometrical tumor coverage using the contrast-enhanced (ce-)CT images acquired before and within 24 h after radiofrequency (RF) ablation.
Twenty patients (6 male and 14 female, median age 62 years) with 45 focal hypovascular liver metastases (16 colorectal carcinoma, 3 melanoma and 1 breast carcinoma) underwent RF ablation under CT-guidance and received a ce-PET/CT scan within 24 h post-procedure. Pre- and post-ablation ce-CT-images were aligned using an interactive procedure and used to verify the tumor coverage of the RF ablation. Results were correlated to LTP as recorded during follow-up performed every 2–3 months after the intervention (mean follow-up of 110 weeks) and compared to standard reading performed by three readers of the ce-CT images.
Eleven tumors (25%) showed LTP during the follow-up period. One lesion, which did not show LTP, was excluded from analysis due to the poor quality of the alignment. For the remaining, 29 (66%) tumors were completely covered by the ablation zone, 9 (20%) were not, and for 6 (14%) tumors the edges coincided with the edge of the ablation zone. The sensitivity, specificity, PPV and NPV for LTP of having incomplete tumor coverage or no apparent ablative margin versus standard reading of ce-CT were 100, 88, 73 and 100% versus 42, 88, 58 and 82%, respectively.
Verifying the tumor coverage of liver metastases by an ablation zone through alignment of pre- and early post-ablation ce-CT images has a high predictive value for LTP.
Ahmed M, Solbiati L, Brace CL, Breen DJ, Callstrom MR, Charboneau JW, Chen MH, Choi BI, de Baere T, Dodd GD, 3rd, Dupuy DE, Gervais DA, Gianfelice D, Gillams AR, Lee FT, Jr., Leen E, Lencioni R, Littrup PJ, Livraghi T, Lu DS, McGahan JP, Meloni MF, Nikolic B, Pereira PL, Liang P, Rhim H, Rose SC, Salem R, Sofocleous CT, Solomon SB, Soulen MC, Tanaka M, Vogl TJ, Wood BJ, Goldberg SN, International Working Group on Image-Guided Tumor A, Interventional Oncology Sans Frontieres Expert P, Technology Assessment Committee of the Society of Interventional R, Standard of Practice Committee of the C, Interventional Radiological Society of E (2014) Image-guided tumor ablation: standardization of terminology and reporting criteria—a 10-year update. J Vasc Interv Radiol 25(11):1691–1705 e1694. https://doi.org/10.1016/j.jvir.2014.08.027
Mulier S, Ni Y, Jamart J, Ruers T, Marchal G, Michel L (2005) Local recurrence after hepatic radiofrequency coagulation: multivariate meta-analysis and review of contributing factors. Ann Surg 242(2):158–171 CrossRef
Penna C, Nordlinger B (2002) Colorectal metastasis (liver and lung). Surg Clin North Am 82(5):1075–1090 x-xi CrossRef
Abdalla EK, Vauthey JN, Ellis LM, Ellis V, Pollock R, Broglio KR, Hess K, Curley SA (2004) Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg 239(6):818–825 (discussion 825–817) CrossRef
Shady W, Petre EN, Gonen M, Erinjeri JP, Brown KT, Covey AM, Alago W, Durack JC, Maybody M, Brody LA, Siegelbaum RH, D’Angelica MI, Jarnagin WR, Solomon SB, Kemeny NE, Sofocleous CT (2016) Percutaneous radiofrequency ablation of colorectal cancer liver metastases: factors affecting outcomes—a 10-year experience at a single center. Radiology 278(2):601–611. https://doi.org/10.1148/radiol.2015142489 CrossRefPubMed
Choi H, Loyer EM, DuBrow RA, Kaur H, David CL, Huang S, Curley S, Charnsangavej C (2001) Radio-frequency ablation of liver tumors: assessment of therapeutic response and complications. Radiographics: a review publication of the Radiological Society of North America, Inc 21 Spec No:S41–54 CrossRef
Schraml C, Clasen S, Schwenzer NF, Koenigsrainer I, Herberts T, Claussen CD, Pereira PL (2008) Diagnostic performance of contrast-enhanced computed tomography in the immediate assessment of radiofrequency ablation success in colorectal liver metastases. Abdom Imaging 33(6):643–651. https://doi.org/10.1007/s00261-007-9351-9 CrossRefPubMed
Fujioka C, Horiguchi J, Ishifuro M, Kakizawa H, Kiguchi M, Matsuura N, Hieda M, Tachikake T, Alam F, Furukawa T, Ito K (2006) A feasibility study: evaluation of radiofrequency ablation therapy to hepatocellular carcinoma using image registration of preoperative and postoperative CT. Acad Radiol 13(8):986–994. https://doi.org/10.1016/j.acra.2006.05.011 CrossRefPubMed
Vandenbroucke F, Vandemeulebroucke J, Ilsen B, Verdries D, Belsack D, Everaert H, Buls N, Ros PR, de Mey J (2014) Predictive value of pattern classification 24 hours after radiofrequency ablation of liver metastases on CT and positron emission tomography/CT. J Vasc Interv Radiol. https://doi.org/10.1016/j.jvir.2014.04.020 CrossRefPubMed
Stang A, Oldhafer KJ, Weilert H, Keles H, Donati M (2014) Selection criteria for radiofrequency ablation for colorectal liver metastases in the era of effective systemic therapy: a clinical score based proposal. BMC Cancer 14:500. https://doi.org/10.1186/1471-2407-14-500 CrossRefPubMedPubMedCentral
Vandenbroucke F, Ilsen B, Craggs B, Op de Beeck B, de Mey J (2007) Radiofrequency ablation of the liver: how do we do it. JBR-BTR 90(6):490–491 PubMed
Dromain C, de Baere T, Elias D, Kuoch V, Ducreux M, Boige V, Petrow P, Roche A, Sigal R (2002) Hepatic tumors treated with percutaneous radio-frequency ablation: CT and MR imaging follow-up. Radiology 223(1):255–262 CrossRef
Chopra S, Dodd GD 3rd, Chintapalli KN, Leyendecker JR, Karahan OI, Rhim H (2001) Tumor recurrence after radiofrequency thermal ablation of hepatic tumors: spectrum of findings on dual-phase contrast-enhanced CT. AJR Am J Roentgenol 177(2):381–387. https://doi.org/10.2214/ajr.177.2.1770381 CrossRefPubMed
Filippone A, Iezzi R, Di Fabio F, Cianci R, Grassedonio E, Storto ML (2007) Multidetector-row computed tomography of focal liver lesions treated by radiofrequency ablation: spectrum of findings at long-term follow-up. J Comput Assist Tomogr 31(1):42–52. https://doi.org/10.1097/01.rct.0000232264.36178.1e CrossRefPubMed
Smith S, Gillams A (2008) Imaging appearances following thermal ablation. Clin Radiol 63(1):1–11. https://doi.org/10.1016/j.crad.2007.06.002 CrossRefPubMed
Tani S, Tatli S, Hata N, Garcia-Rojas X, Olubiyi OI, Silverman SG, Tokuda J (2016) Three-dimensional quantitative assessment of ablation margins based on registration of pre- and post-procedural MRI and distance map. Int J Comput Assist Radiol Surg 11(6):1133–1142. https://doi.org/10.1007/s11548-016-1398-z CrossRefPubMedPubMedCentral
Kettenbach J, Kostler W, Rucklinger E, Gustorff B, Hupfl M, Wolf F, Peer K, Weigner M, Lammer J, Muller W, Goldberg SN (2003) Percutaneous saline-enhanced radiofrequency ablation of unresectable hepatic tumors: initial experience in 26 patients. AJR Am J Roentgenol 180(6):1537–1545. https://doi.org/10.2214/ajr.180.6.1801537 CrossRefPubMed
Pawlik TM, Izzo F, Cohen DS, Morris JS, Curley SA (2003) Combined resection and radiofrequency ablation for advanced hepatic malignancies: results in 172 patients. Ann Surg Oncol 10(9):1059–1069 CrossRef
Wood TF, Rose DM, Chung M, Allegra DP, Foshag LJ, Bilchik AJ (2000) Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations, and complications. Ann Surg Oncol 7(8):593–600 CrossRef
Vandenbroucke F, Vandemeulebroucke J, Ilsen B, Verdries D, Belsack D, Everaert H, Buls N, Ros PR, de Mey J (2014) Predictive value of pattern classification 24 hours after radiofrequency ablation of liver metastases on CT and positron emission tomography/CT. J Vasc Interv Radiol 25(8):1240–1249. https://doi.org/10.1016/j.jvir.2014.04.020 CrossRefPubMed
Makino Y, Imai Y, Igura T, Hori M, Fukuda K, Sawai Y, Kogita S, Fujita N, Takehara T, Murakami T (2015) Comparative evaluation of three-dimensional Gd-EOB-DTPA-enhanced MR fusion imaging with CT fusion imaging in the assessment of treatment effect of radiofrequency ablation of hepatocellular carcinoma. Abdom Imaging 40(1):102–111. https://doi.org/10.1007/s00261-014-0201-2 CrossRefPubMed
Rieder C, Geisler B, Bruners P, Isfort P, Na H-S, Mahnken AH, Hahn HK (2014) Software-assisted post-interventional assessment of radiofrequency ablation. In: SPIE medical imaging, 2014. SPIE, p 8
Voglreiter P, Mariappan P, Pollari M, Flanagan R, Blanco Sequeiros R, Portugaller RH, Futterer J, Schmalstieg D, Kolesnik M, Moche M (2018) RFA guardian: comprehensive simulation of radiofrequency ablation treatment of liver tumors. Sci Rep 8(1):787. https://doi.org/10.1038/s41598-017-18899-2 CrossRefPubMedPubMedCentral
- Can tumor coverage evaluated 24 h post-radiofrequency ablation predict local tumor progression of liver metastases?
Ruedi F. Thoeni
Johan de Mey
- Springer International Publishing
International Journal of Computer Assisted Radiology and Surgery
A journal for interdisciplinary research, development and applications of image guided diagnosis and therapy
Print ISSN: 1861-6410
Elektronische ISSN: 1861-6429
Neuer Inhalt/© ITandMEDIA