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Erschienen in:
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2017 | OriginalPaper | Buchkapitel

4. Case Study: Osseointegration of Strontium Containing Glass Ceramic

verfasst von : Bikramjit Basu, Sourabh Ghosh

Erschienen in: Biomaterials for Musculoskeletal Regeneration

Verlag: Springer Singapore

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Abstract

The most important property of bone cement or a bone substitute in load bearing orthopaedic implants is good integration with host bone with reduced bone resorption and increased bone regeneration at the implant interface. Long term implantation of metal-based joint replacements often results in corrosion and particle release, initiating chronic inflammation leading onto osteoporosis of host bone. An alternative solution is the coating of metal implants with hydroxyapatite (HA) or bioglass or the use of bulk bioglass or HA-based composites. One of the desired properties for any new biomaterial composition is its long term stability in a suitable animal model and such property cannot be appropriately assessed by performing short term implantation studies. While hydroxyapatite or bioglass coated metallic biomaterials are being investigated for in vivo biocompatibility properties, such study is not extensively being pursued for bulk glass ceramics. In view of their inherent brittle nature, the implant stability as well as impact of long term release of metallic ions on bone regeneration have been a major concern. In the above perspective, the present study reports the in vivo biocompatibility and bone healing of the strontium (Sr)-stabilized bulk glass ceramics with the nominal composition of 4.5SiO2–3Al2O3–1.5P2O5–3SrO–2SrF2 during short term implantation of up to 12 weeks in rabbit animal model followed by long term implantation for 26 weeks in cylindrical bone defects in rabbit model. The progression of healing and bone regeneration was qualitatively and quantitatively assessed using fluorescence microscopy, histological analysis and micro-computed tomography. The overall assessment of the present study establishes that the investigated glass-ceramic is biocompatible in vivo with regards to local effects after short term implantation in rabbit animal model. Excellent healing was observed, which is comparable to that seen in response to a commercially available implant of HA-based bioglass.

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Vorheriges Kapitel Case Study: Hydroxyapatite Based Microporous/Macroporous Scaffolds
Nächstes Kapitel Microstructure and Composition Dependent Physical and Cytocompatibility Property of Glass-Ceramics for Dental Restoration
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Metadaten
Titel
Case Study: Osseointegration of Strontium Containing Glass Ceramic
verfasst von
Bikramjit Basu
Sourabh Ghosh
Copyright-Jahr
2017
Verlag
Springer Singapore
Buch
Biomaterials for Musculoskeletal Regeneration

Print ISBN: 978-981-10-3016-1

Electronic ISBN: 978-981-10-3017-8

Copyright-Jahr: 2017

DOI
https://doi.org/10.1007/978-981-10-3017-8_4

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