Recent evidence suggests that substance P (SP) may be involved in central regulation of cardiovascular function (1). SP and SP receptors are found in several brainstem structures, among them the nucleus tractus solitarius (NTS) (2, 3), which plays a major role in regulating blood pressure (bp) (4). Afferent fibers of the vagus and glossopharyngeal nerves, some containing SP (5), come from baroreceptors in the carotid sinus and aortic arch, activation of which leads to a depressor effect (fall in bp) (4). Removal of the nodose ganglion leads to a decline in the SP content of those regions of the NTS that receive baroreceptor afferents (6).
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- Central Modulation of Blood Pressure by N- and C-Terminal Fragments of Substance P
I. M. Stewart
M. E. Hall
- Springer New York
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