nach oben

Erschienen in:

01.04.2014

Change in quality of life and predictors of change among patients with multiple sclerosis: a prospective cohort study

verfasst von: Darija Kisic Tepavcevic, Tatjana Pekmezovic, Nebojsa Stojsavljevic, Jelena Kostic, Irena Dujmovic Basuroski, Sarlota Mesaros, Jelena Drulovic

Erschienen in: Quality of Life Research | Ausgabe 3/2014

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

Purpose

The aim of this study was to determine the changes in the health-related quality of life (HRQoL) and predictors of change among patients with multiple sclerosis (MS) at 3 and 6 years during the follow-up period.

Methods

A group of 109 consecutive MS patients (McDonald’s criteria) referred to the Clinic of Neurology, Belgrade, were enrolled in the study. At three time points during the study (baseline, and at 3 and 6 years during the follow-up period), the HRQoL (measured by MSQoL-54), Expanded Disability Status Scale, and Hamilton Rating Scale for Depression and Fatigue Severity Scale were assessed.

Results

During the study period, 93 patients provided both follow-up assessments. Statistically significant deterioration in the HRQoL at each subsequent time point was detected for all scales of the MSQoL-54 except for the pain and change in health scales. A higher level of education was a significant prognostic factor for a better HRQoL on the cognitive function scale throughout the entire period of observation, while marital status (single, including divorced and widowed) and increased age at the onset of MS had significant predictive values of poorer quality-of-life scores on the overall quality-of-life scale at 6-year follow-up. Higher levels of physical disability and depression at baseline were statistically significant prognostic markers for deterioration in HRQoL for the majority of MSQoL-54 scales during the entire follow-up period.

Conclusions

Our study suggests that baseline demographic and clinical characteristics could be applied as prognostic markers of the HRQOL for patients diagnosed with MS.

Vorheriger Artikel The impact of severe preeclampsia on maternal quality of life

Nächster Artikel The mediating role of disability and social support in the association between low vision and depressive symptoms in older adults

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Rudick, R. A., & Miller, D. M. (2008). Health-related quality of life in multiple sclerosis: Current evidence, measurement and effects of disease severity and treatment. CNS Drugs, 22(10), 827–839.PubMedCrossRef

Hopman, W. M., Coo, H., Edgar, C. M., McBride, E. V., Day, A. G., & Brunet, D. G. (2007). Factors associated with health-related quality of life in multiple sclerosis. Canadian Journal of Neurological Sciences, 34(2), 160–166.PubMed

Benedict, R. H., Wahlig, E., Bakshi, R., Fishman, I., Munschauer, F., Zivadinov, R., et al. (2005). Predicting quality of life in multiple sclerosis: Accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change. Journal of the Neurological Sciences, 231(1–2), 29–34.PubMedCrossRef

Mitchell, A. J., Benito-León, J., González, J. M., & Rivera-Navarro, J. (2005). Quality of life and its assessment in multiple sclerosis: Integrating physical and psychological components of wellbeing. Lancet Neurology, 4(9), 556–566.PubMedCrossRef

Rothwell, P. M., McDowell, Z., Wong, C. K., & Dorman, P. J. (1997). Doctors and patients don’t agree: Cross sectional study of patients’ and doctors’ perceptions and assessments of disability in multiple sclerosis. British Medical Journal, 314(7094), 1580–1583.PubMedCentralPubMedCrossRef

Hadgkiss, E. J., Jelinek, G. A., Weiland, T. J., Rumbold, G., Mackinlay, C. A., Gutbrod, S., et al. (2013). Health-related quality of life outcomes at 1 and 5 years after a residential retreat promoting lifestyle modification for people with multiple sclerosis. Journal of the Neurological Sciences, 34(2), 187–195.CrossRef

Drulovic, J., Pekmezovic, T., Matejic, B., Mesaros, S., Manigoda, M., Dujmovic, I., et al. (2007). Quality of life in patients with multiple sclerosis in Serbia. Acta Neurologica Scandinavica, 115(3), 147–152.PubMedCrossRef

Tepavcevic, D. K., Kostic, J., Basuroski, I. D., Stojsavljevic, N., Pekmezovic, T., & Drulovic, J. (2008). The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis. Multiple Sclerosis, 14(8), 1131–1136.PubMedCrossRef

Miller, D. M., Weinstock-Guttman, B., Bourdette, D., You, X., Foulds, P., & Rudick, R. A. (2011). Change in quality of life in patients with relapsing-remitting multiple sclerosis over 2 years in relation to other clinical parameters: results from a trial of intramuscular interferon {beta}-1a. Multiple Sclerosis, 17(6), 734–742.PubMedCrossRef

10.

Rudick, R. A., Miller, D., Hass, S., Hutchinson, M., Calabresi, P. A., Confavreux, C., et al. (2007). Health-related quality of life in multiple sclerosis: effects of natalizumab. Annals of Neurology, 62(4), 335–346.PubMedCrossRef

11.

Nortvedt, M. W., Riise, T., Myhr, K. M., & Nyland, H. I. (1999). Quality of life in multiple sclerosis: Measuring the disease effects more broadly. Neurology, 53(5), 1098–1103.PubMedCrossRef

12.

Hermann, B. P., Vickrey, B., Hays, R. D., Cramer, J., Devinsky, O., Meador, K., et al. (1996). A comparison of health-related quality of life in patients with epilepsy, diabetes and multiple sclerosis. Epilepsy Research, 25(2), 113–118.PubMedCrossRef

13.

Riazi, A., Hobart, J. C., Lamping, D. L., Fitzpatrick, R., Freeman, J. A., Jenkinson, C., et al. (2003). Using the SF-36 measure to compare the health impact of multiple sclerosis and Parkinson’s disease with normal population health profiles. Journal of Neurology, Neurosurgery and Psychiatry, 74(6), 710–714.PubMedCentralPubMedCrossRef

14.

Miller, D. M., Rudick, R. A., Baier, M., Cutter, G., Doughtery, D. S., Weinstock-Guttman, B., et al. (2003). Factors that predict health-related quality of life in patients with relapsing-remitting multiple sclerosis. Multiple Sclerosis, 9(1), 1–5.PubMedCrossRef

15.

Füvesi, J., Bencsik, K., Losonczi, E., Fricska-Nagy, Z., Mátyás, K., Mészáros, E., et al. (2010). Factors influencing the health-related quality of life in Hungarian multiple sclerosis patients. Journal of the Neurological Sciences, 293(1–2), 59–64.PubMedCrossRef

16.

Lobentanz, I. S., Asenbaum, S., Vass, K., Sauter, C., Klösch, G., Kollegger, H., et al. (2004). Factors influencing quality of life in multiple sclerosis patients: disability, depressive mood, fatigue and sleep quality. Acta Neurologica Scandinavica, 110(1), 6–13.PubMedCrossRef

17.

Pfaffenberger, N., Pfeiffer, K. P., Deibl, M., Höfer, S., Günther, V., & Ulmer, H. (2006). Association of factors influencing health-related quality of life in MS. Acta Neurologica Scandinavica, 114(2), 102–108.PubMedCrossRef

18.

Patti, F., Cacopardo, M., Palermo, F., Ciancio, M. R., Lopes, R., Restivo, D., et al. (2003). Health-related quality of life and depression in an Italian sample of multiple sclerosis patients. Journal of the Neurological Sciences, 211(1–2), 55–62.PubMedCrossRef

19.

McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H. P., Lublin, F. D., et al. (2001). Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International panel on the diagnosis of multiple sclerosis. Annals of Neurology, 50(1), 121–127.PubMedCrossRef

20.

Kurtzke, J. F. (1983). Rating neurologic instrument in multiple sclerosis: An expanded disability status scale (EDSS). Neurology, 33, 1444–1452.PubMedCrossRef

21.

Vickrey, B. G., Hays, R. D., Harooni, R., Myeres, L. W., & Ellison, G. W. (1995). A health-related quality of life measure for multiple sclerosis. Quality of Life Research, 4(3), 187–206.PubMedCrossRef

22.

Pekmezovic, T., Kisic Tepavcevic, D., Kostic, J., & Drulovic, J. (2007). Validation and cross-cultural adaptation of the disease-specific questionnaire MSQoL-54 in Serbian multiple sclerosis patients sample. Quality of Life Research, 16(8), 1383–1387.PubMedCrossRef

23.

Likert, R. A. (1932). A technique for the development of attitudes. Archives of Psychology, 140, 5–55.

24.

Krupp, L. B., Larocca, N. G., Nash, J. M., & Steinberg, A. D. (1989). The Fatigue Severity Scale. Application to patients with multiple sclerosis and systematic lupus erythematosus. Archives of Neurology, 46, 1121–1123.PubMedCrossRef

25.

Hamilton, M. (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–286.PubMedCrossRef

26.

Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). New York: Academic Press.

27.

Hopman, W. M., Coo, H., Pavlov, A., Day, A. G., Edgar, C. M., McBride, E. V., et al. (2009). Multiple sclerosis: Change in health-related quality of life over two years. Canadian Journal of Neurological Sciences, 36(5), 554–561.PubMed

28.

Hopman, W. M., Coo, H., Brunet, D. G., Edgar, C. M., & Singer, M. A. (2000). Longitudinal assessment of health-related quality of life (HRQL) of patients with multiple sclerosis. International Journal of MS Care, 2, 15–26.CrossRef

29.

Solari, A., Ferrari, G., & Radice, D. (2006). A longitudinal survey of self-assessed health trends in a community cohort of people with multiple sclerosis and their significant others. Journal of Neurological Sciences, 243(1–2), 13–20.CrossRef

30.

Wynia, K., van Wijlen, A. T., Middel, B., Reijneveld, S. A., & Meilof, J. F. (2012). Change in disability profile and quality of life in multiple sclerosis patients: A five-year longitudinal study using the Multiple Sclerosis Impact Profile (MSIP). Multiple Sclerosis, 18(5), 654–661.PubMedCrossRef

31.

Busche, K. D., Fisk, J. D., Murray, T. J., & Metz, L. M. (2003). Short term predictors of unemployment in multiple sclerosis patients. Canadian Journal of Neurological Sciences, 30(2), 137–142.PubMed

32.

Spain, L. A., Tubridy, N., Kilpatrick, T. J., Adams, S. J., & Holmes, A. C. (2007). Illness perception and health-related quality of life in multiple sclerosis. Acta Neurologica Scandinavica, 116(5), 293–299.PubMedCrossRef

33.

Merkelbach, S., Sittinger, H., & Koenig, J. (2002). Is there a differential impact of fatigue and physical disability on quality of life in multiple sclerosis? Journal of Nervous and Mental Disease, 190(6), 388–393.PubMedCrossRef

34.

Chwastiak, L., Ehde, D. M., Gibbons, L. E., Sullivan, M., Bowen, J. D., & Kraft, G. H. (2002). Depressive symptoms and severity of illness in multiple sclerosis: Epidemiologic study of a large community sample. American Journal of Psychiatry, 159(11), 1862–1868.PubMedCrossRef

35.

Fruehwald, S., Loeffler-Stastka, H., Eher, R., Saletu, B., & Baumhackl, U. (2001). Depression and quality of life in multiple sclerosis. Acta Neurologica Scandinavica, 104(5), 257–261.PubMedCrossRef

Titel: Change in quality of life and predictors of change among patients with multiple sclerosis: a prospective cohort study
verfasst von: Darija Kisic Tepavcevic
Tatjana Pekmezovic
Nebojsa Stojsavljevic
Jelena Kostic
Irena Dujmovic Basuroski
Sarlota Mesaros
Jelena Drulovic
Publikationsdatum: 01.04.2014
Verlag: Springer International Publishing
Erschienen in: Quality of Life Research / Ausgabe 3/2014
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-013-0535-1

Springer Professional

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Wirtschaft"

Weitere Artikel der Ausgabe 3/2014

The EORTC QLQ-C15-PAL questionnaire: validation study for Spanish bone metastases patients

Equivalence and measurement properties of an electronic version of the Psoriasis Symptom Inventory

Development and validation of the functional assessment of chronic illness therapy treatment satisfaction (FACIT TS) measures

Measuring pediatric patient-reported outcomes: good progress but a long way to go

Health-risk behaviors and quality of life among young men

Assessing the performance of the EQ-VAS in the NHS PROMs programme