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Erschienen in:
Age-Related Changes in Whole-Bone Structure and Strength Kapitel lesen Erstes Kapitel lesen

2013 | OriginalPaper | Buchkapitel

Changes in Cortical Bone Mineral and Microstructure with Aging and Osteoporosis

verfasst von : Janardhan Yerramshetty, Ozan Akkus

Erschienen in: Skeletal Aging and Osteoporosis

Verlag: Springer Berlin Heidelberg

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Abstract

Microstructural and nanocompositional changes in bone’s fabric with age and osteoporosis have not been reviewed as much in-depth as the macroscale changes. This chapter discusses alterations in the size and shape of mineral crystallites as a function of aging and, also, as result of osteoporosis. The review also covers the variations in the microstructure, specifically, porosity, fraction of osteonal bone and collagen orientation. Besides the average values for these variables, the variation (i.e. heterogeneity) of these variables is also discussed. The observed results are discussed within the context of changes in the dynamics of remodeling with age and osteoporosis. Overall, there are discrepancies in the literature for a significant portion of the variables reported due to a host of issues such as the lack of statistical power, large scatter inherent in the biological data, variation of age-range, gender, anatomical region or the methodology employed to assess a given variable.

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Vorheriges Kapitel Bone Microdamage and Its Contributions to Fracture
Nächstes Kapitel Factor of Risk for Fracture
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Metadaten
Titel
Changes in Cortical Bone Mineral and Microstructure with Aging and Osteoporosis
verfasst von
Janardhan Yerramshetty
Ozan Akkus
Copyright-Jahr
2013
Verlag
Springer Berlin Heidelberg
Buch
Skeletal Aging and Osteoporosis

Print ISBN: 978-3-642-18052-1

Electronic ISBN: 978-3-642-18053-8

Copyright-Jahr: 2013

DOI
https://doi.org/10.1007/8415_2012_114

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