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Energy Homeostasis and the Tumor/Host Interaction: The role of the Brain

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Integration/Interaction of Oncologic Growth

Part of the book series: Cancer Growth and Progression ((CAGP,volume 15))

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Abstract

The defensive regulation of energy homeostasis by neural and endocrine systems is examined to evaluate the role of the brain in macroenvironmental metabolic control systems that help counterattack the aggressive tumor. Brain homeostatic mechanisms (neural and hormonal) discussed are those linked to metabolic rhythms, food intake and adiposity. Homeostasis is discussed in terms of rheostasis, the low probability of dysregulation, and the potential risks for the defense. The perspective of this review is that many of the metabolic alterations observed in tumor progression may be due to appropriate central homeostatic regulation. Clear deficits in homeostatic regulation during tumor growth have not been unequivocally demonstrated. Yet the brain of the host is clearly under duress due to the tumor. Clarification of homeostatic macroenvironmental regulatory responses may be useful in developing strategies that collaborate with these brain mechanisms. Further analysis of these regulatory systems may identify key changes that ultimately subserve the lethal failure of all host responses. Strategies that protect the brain from the pathological consequences of tumor growth (glucoprivation, oxidative stress, ketogenic diets) and thereby enable a stronger defense are discussed.

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References

  1. Bernard, C., 1878, Leçons sur les phénomènes de la vie communs aux animaux et aux végétaux. J-B Baillière et fils, Paris, France.

    Google Scholar 

  2. Cannon, W.B., 1929, Organization for physiological homeostasis. Physiol Rev, 9:399–431.

    Google Scholar 

  3. Cannon, W.B., 1939, The wisdom of the body. W.W. Norton & Co. Inc., New York, NY, USA.

    Google Scholar 

  4. Mrosovsky, N., 1990, Rheostasis: the physiology of change.: Oxford University Press. New York

    Google Scholar 

  5. Saper, C.B., Chou, T.C., and Elmquist, J.K. 2002 The need to feed: homeostatic and hedonic control of eating. Neuron 36: 199–211.

    Article  PubMed  Google Scholar 

  6. Berthoud, H.R. 2002 Multiple neural systems controlling food intake and body weight. Neurosci Biobehav Rev 26: 393–428.

    Article  PubMed  Google Scholar 

  7. Blevins, J.E., Schwartz, M.W., and Baskin, D.G. 2002 Peptide signals regulating food intake and energy homeostasis. Can J Physiol Pharmacol 80: 396–406.

    Article  PubMed  Google Scholar 

  8. Horvath, T.L., Diano, S., and Tschop, M. 2004 Brain circuits regulating energy homeostasis. Neuroscientist 10: 235–46.

    Article  Google Scholar 

  9. Flier, J., and Maratos-Flier, E. 2000 Energy homeostasis and body weight. Curr Biol 10: R215–7.

    PubMed  Google Scholar 

  10. Havel, P.J. 2001 Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med (Maywood) 226: 963–77.

    Google Scholar 

  11. Meier, U., and Gressner, A.M. 2004 Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 50: 1511–25.

    Article  PubMed  Google Scholar 

  12. Cowley, M.A., Pronchuk, N., Fan, W., Dinulescu, D.M., Colmers, W.F., and Cone, R.D. 1999 Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24: 155–63.

    Article  PubMed  Google Scholar 

  13. Epstein, A.N., Nicolaïdis, S. and Miselis, R. 1975. The glucoprivic control of food intake and the glucostatic theory of feeding behaviour. Pp 146–168 in Neural integration of physiological mechanisms and behavior, Mogenson G.J. and Calaresu, F.R, eds. Toronto: University of Toronto Press.

    Google Scholar 

  14. La Fleur, S.E. 2003 Daily rhythms in glucose metabolism: suprachiasmatic nucleus output to peripheral tissue. J Neuroendocrinol 15: 315–22.

    Article  PubMed  Google Scholar 

  15. Kreier, F., Kalsbeek, A., Ruiter, M., Yilmaz, A., Romijn, J.A., Sauerwein, H.P., Fliers, E., and Buijs, R.M. 2003 Central nervous determination of food storage—a daily switch from conservation to expenditure: implications for the metabolic syndrome. Eur J Pharmacol 480: 51–65.

    Article  Google Scholar 

  16. Schibler, U., Ripperger, J., and Brown, S.A. 2003 Peripheral circadian oscillators in mammals: time and food. J Biol Rhythms 18: 250–60.

    Article  PubMed  Google Scholar 

  17. Challet, E., Caldelas, I., Graff, C., and Pevet, P. 2003 Synchronization of the molecular clockwork by light-and food-related cues in mammals. Biol Chem 384: 711–9.

    Article  Google Scholar 

  18. Rutter, J., Reick, M., and McKnight, S.L. 2002 Metabolism and the control of circadian rhythms. Annu Rev Biochem 71: 307–31.

    Article  PubMed  Google Scholar 

  19. Nagai, K., Nagai, N., Sugahara, K., Niijima, A., and Nakagawa, H. 1994 Circadian rhythms and energy metabolism with special reference to the suprachiasmatic nucleus. Neurosci Biobehav Rev 18: 579–84.

    Article  PubMed  Google Scholar 

  20. Strubbe, J.H., and van Dijk, G. 2002 The temporal organization of ingestive behaviour and its interaction with regulation of energy balance. Neurosci Biobehav Rev 26: 485–98.

    Article  Google Scholar 

  21. Stephan, F.K. 2002 The “other” circadian system: food as a Zeitgeber. J Biol Rhythms 17: 284–92.

    Article  PubMed  Google Scholar 

  22. Mistlberger, R.E. 1994 Circadian food-anticipatory activity: formal models and physiological mechanisms. Neurosci Biobehav Rev 18: 171–95.

    Article  PubMed  Google Scholar 

  23. Lee, K., Cho, M., Miaskowski, C., and Dodd, M. 2004 Impaired sleep and rhythms in persons with cancer. Sleep Med Rev 8: 199–212.

    Article  PubMed  Google Scholar 

  24. Sephton, S., and Spiegel, D. 2003 Circadian disruption in cancer: a neuroendocrine-immune pathway from stress to disease? Brain Behav Immun 17: 321–8.

    Article  PubMed  Google Scholar 

  25. Fu, L., and Lee, C.C. 2003 The circadian clock: pacemaker and tumour suppressor. Nat Rev Cancer 3: 350–61.

    Article  PubMed  Google Scholar 

  26. Mormont, M.C., and Levi, F. 2003 Cancer chronotherapy: principles, applications, and perspectives. Cancer 97: 155–69.

    Article  PubMed  Google Scholar 

  27. Argiles, J.M., Almendro, V., Busquets, S., and Lopez-Soriano, F.J. 2004 The pharmacological treatment of cachexia. Curr Drug Targets 5: 265–77.

    Article  PubMed  Google Scholar 

  28. Tayek, J.A. 1992 A review of cancer cachexia and abnormal glucose metabolism in humans with cancer. J Am Coll Nutr 11: 445–56.

    PubMed  Google Scholar 

  29. Thompson, M.G, and Palmer, R.M. 1998 Signalling pathways regulating protein turnover in skeletal muscle. Cell Signal 10: 1–11.

    Article  PubMed  Google Scholar 

  30. Baron, A., Migita, T., Tang, D., and Loda, M. 2004 Fatty acid synthase: a metabolic oncogene in prostate cancer? J Cell Biochem 91: 47–53.

    Article  PubMed  Google Scholar 

  31. Tisdale, M.J. 2004 Tumor-host interactions. J Cell Biochem 93: 871–7.

    Article  PubMed  Google Scholar 

  32. van Halteren, H.K., Bongaerts, G.P., and Wagener, D.J. 2003 Cancer cachexia: what is known about its etiology and what should be the current treatment approach? Anticancer Res 23: 5111–5.

    PubMed  Google Scholar 

  33. Morrison, S.D. 1976 Control of food intake in cancer cachexia: a challenge and a tool. Physiol Behav 17: 705–714.

    Article  PubMed  Google Scholar 

  34. Morrison, S.D. 1981 Control of food intake in experimental tumor growth. Cancer Treat Rep 65(Suppl 5): 9–14.

    Google Scholar 

  35. Molotkov, A., Satoh, M., and Tohyama, C. 1998 Tumor growth and food intake in interleukin-6 gene knock-out mice. Cancer Lett 132: 187–92.

    Article  PubMed  Google Scholar 

  36. Thompson, C.I., Kreider, J.W., and Margules, D.L. 1984 Food intake during tumor growth: anorexia in genetically obese ob/ob mice and hyperphagia in lean mice. Physiol Behav 32: 935–9.

    Article  PubMed  Google Scholar 

  37. Rofe, A.M., Porter, S.J., Bais, R., and Coyers, R.A.J. 1985 The metabolic response of tumour-bearing mice to fasting. Br J Cancer 52: 619–623.

    PubMed  Google Scholar 

  38. Devereux, D.F., Redgrave, T.G., Loda, M.F., Clowes, G.H. Jr, and Deckers, P.J. 1985 Tumorassociated metabolism in the rat is a unique physiologic entity. J Surg Res 38: 149–53.

    Article  Google Scholar 

  39. Coleman, D.L. 1979 Obesity genes: beneficial effects in heterozygous mice. Science 203: 663–5.

    PubMed  Google Scholar 

  40. Cabanac, M. and Russek, M. 1982 Régulation et contrôle en biologie. Les Presses de l'Université Laval, Québec.

    Google Scholar 

  41. Cryer, P.E. 2002 Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes. Diabetologia 45: 937–48.

    Article  PubMed  Google Scholar 

  42. Sanders, N.M., and Ritter, S. 2001 Acute 2DG-induced glucoprivation or dexamethasone abolishes 2DG-induced glucoregulatory responses to subsequent glucoprivation. Diabetes 50: 2831–6.

    PubMed  Google Scholar 

  43. Johnson, K.G., and Cabanac, M. 1982 Homeostatic competition between food intake and temperature regulation in rats. Physiol Behav 28: 675–9.

    Article  PubMed  Google Scholar 

  44. Mrosovsky, N. 1986 Body fat: what is regulated? Physiol Behav 38: 407–14.

    Article  PubMed  Google Scholar 

  45. Cancello, R., Tounian, A., Poitou, Ch., and Clement, K. 2004 Adiposity signals, genetic and body weight regulation in humans. Diabetes Metab 30: 215–27.

    PubMed  Google Scholar 

  46. Wynne, K., Stanley, S., and Bloom, S. 2004 The gut and regulation of body weight. J Clin Endocrinol Metab 89: 2576–82.

    Article  PubMed  Google Scholar 

  47. Tremblay, A. 2004 Dietary fat and body weight set point. Nutr Rev 62: S75–7.

    Article  PubMed  Google Scholar 

  48. Cone, R.D., Cowley, M.A., Butler, A.A., Fan, W., Marks, D.L., and Low, M.J. 2001 The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int J Obes Relat Metab Disord 25Suppl 5: S63–7.

    Article  Google Scholar 

  49. Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Hecht, R., Winters, D., Boone, T., and Collins, F. 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540–543

    PubMed  Google Scholar 

  50. Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., and Burn, P. 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546–549.

    PubMed  Google Scholar 

  51. Halaas, J.L., Gajiwala, K.S., Maffei, M., Cohen, S.L., Chait, B.T., Rabinowitz, D., Lallone, R.L., Burley, S.K., and Friedman, J.M. 1995 Weight regulation effects of the plasma protein encoding the obese gene. Science 269: 543–6.

    PubMed  Google Scholar 

  52. Matson, C.A., Wiater, M.F., and Weigle, D.S. 1996 Leptin and the regulation of body adiposity: A critical review. Diabetes Rev 4: 488–508.

    Google Scholar 

  53. Baile, C.A., Della-Fera, M.A., and Martin, R.J. 2000 Regulation of metabolism and body fat mass by leptin. Annu Rev Nutr 20: 105–27.

    Article  PubMed  Google Scholar 

  54. Spiegelman, B.M., and Flier, J.S. 2001 Obesity and the regulation of energy balance. Cell 104: 531–543.

    Article  PubMed  Google Scholar 

  55. Friedman, J.M., and Halaas, J.L. 1998 Leptin and the regulation of body weight in mammals. Nature 395: 763–70.

    Article  PubMed  Google Scholar 

  56. Azain, M.J., Wang, T., Hulsey, M.G., Qian, H., Hartzell, D.L., and Baile, C.A. 1999 Effects of intracerebroventricularly administered leptin on protein selection in the rat. Physiol Behav 66: 537–541.

    Article  PubMed  Google Scholar 

  57. Kaibara, A., Moshyedi, A., Auffenberg, T., Abouhamze, A., Copeland, E.M., III, Kalra, S., and Moldawer, L.L. 1998 Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting. Amer J Physiol 274: R1518–R1525.

    PubMed  Google Scholar 

  58. Chen, Y., and Heiman, M.L. 2000. Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats. Reg Peptides 92: 113–119.

    Article  Google Scholar 

  59. Dallman, M.F., Akana, S.K., Bhatnagar, S., Bell, M.E., Choi, S., Chu, A., Horsley, C., Levin, N., Meijer, O., Soriano, L.R., Strack A.M., and Viau, V. 1999 Starvation: early signals, sensors, and sequelae. Endocrinology 140: 4015–4023.

    Article  PubMed  Google Scholar 

  60. Goodman, M.N., and Ruderman, N.B. 1980 Starvation in the rat. I. Effect of age and obesity on organ weights, RNA, DNA, and protein. Am J Physiol 239: E269–E276.

    PubMed  Google Scholar 

  61. van Dijk, G., Seeley, R.J., Thiele, T.E., Friedman, M.I., Ji, H., Wilkinson, C.W., Burn, P., Campfield, L.A., Tenenbaum, R., Baskin, D.G., Woods, S.C., and Schwartz, M.W. 1999 Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat. Am J Physiol 276: R1425–33.

    PubMed  Google Scholar 

  62. Cohen, P., Zhao, C., Cai, X., Montez, J.M., Rohani, S.C. Feinstein, P., Mombaerts, P., and Friedman, J.M. 2001 Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 108: 1113–21.

    Article  PubMed  Google Scholar 

  63. Kowalski, T.J., Liu, S.M., Leibel, R.L., and Chua, S.C. Jr. 2001 Transgenic complementation of leptinreceptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes 50: 425–35.

    PubMed  Google Scholar 

  64. Duff, E., Li, C.L., Hartzell, D.L., Choi, Y.H., Della-Fera, M.A., and Baile, C.A. 2004 Ciliary neurotrophic factor injected icv induces adipose tissue apoptosis in rats. Apoptosis 9: 629–34.

    Article  PubMed  Google Scholar 

  65. Beretta, E., Dhillon, H., Kalra, P.S., and Kalra, S.P. 2002 Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods. Peptides 23: 975–84.

    Article  PubMed  Google Scholar 

  66. Jansson, J.O., Wallenius, K., Wernstedt, I., Ohlsson, C., Dickson, S.L., and Wallenius, V. 2003 On the site and mechanism of action of the anti-obesity effects of interleukin-6. Growth Horm IGF Res 13Suppl A: S28–32.

    Article  Google Scholar 

  67. Wallenius, K., Wallenius, V., Sunter, D., Dickson, S.L., and Jansson, J.O. 2002 Intracerebroventricular interleukin-6 treatment decreases body fat in rats. Biochem Biophys Res Commun 293: 560–5.

    Article  PubMed  Google Scholar 

  68. Plata-Salaman, CR. 1996 Anorexia induced by activators of the signal transducer gp 130. Neuroreport 7: 841–4.

    PubMed  Google Scholar 

  69. Ishihara, K., and Hirano, T. 2002 Molecular basis of the cell specificity of cytokine action. Biochim Biophys Acta 1592: 281–96.

    Article  Google Scholar 

  70. Taga, T., and Kishimoto, T. 1997 gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15: 797–819.

    Article  PubMed  Google Scholar 

  71. Heinrich, P.C., Behrmann, I., Haan, S., Hermanns, H.M., Muller-Newen, G., and Schaper, F. 2003 Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374: 1–20.

    Article  PubMed  Google Scholar 

  72. Van Wagoner, N.J., Choi, C., Repovic, P., and Benveniste, E.N. 2000 Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38. J Neurochem 75: 563–75.

    Article  Google Scholar 

  73. Hakansson, M.L., Brown, H., Ghilardi, N., Skoda, R.C., and Meister, B. 1998. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 18: 559–72.

    PubMed  Google Scholar 

  74. Schwartz, M.W., Seeley, R.J., Campfield, L.A., Burn, P., and Baskin, D.G. 1996 Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98: 1101–6.

    PubMed  Google Scholar 

  75. Sahu, A. 1998 Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 139: 795–8.

    Article  Google Scholar 

  76. Korner, J., Savontaus, E., Chua, S.C. Jr, Leibel, R.L., and Wardlaw, S.L. 2001 Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. J Neuroendocrinol 13: 959–66.

    Article  Google Scholar 

  77. Costa, A., Poma, A., Martignoni, E., Nazppi, G., Ur, E., and Grossman, A. 1997 Stimulation of corticotrophin-releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants. NeuroReport 8: 1131–34.

    PubMed  Google Scholar 

  78. Uehara, Y., Shimizu, H., Ohtani, K., Sato, N., and Mori, M. 1998 Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin. Diabetes 47: 890–93.

    PubMed  Google Scholar 

  79. Mercer, J.G., Moar, K.M., Findlay, P.A., Hoggard, N., and Adam, C.L. 1998 Association of leptin receptor (OB-Rb), NPY, and GLP-1 gene expression in the ovine and murine brainstem. Regul Pept 75–76: 271–278.

    Article  PubMed  Google Scholar 

  80. Forbes, S., Bui, S., Robinson, B.R., Hochgeschwender, U., and Brennan, M.B. 2001 Integrated control of appetite and fat metabolism by the leptin-prooopiomelanocortin pathway. Proc Natl Acad Sci USA 98: 4233–4237.

    Article  PubMed  Google Scholar 

  81. Sahu, A., Carraway, R.E., and Wang, Y.P. 2001 Evidence that neurotensin mediates the central effect of leptin on food intake in rat. Brain Res 888: 343–347.

    Article  Google Scholar 

  82. Kristensen, P., Judge, M.E., Thim, L., Ribel, U., Christjansen, K.N., Wulff, B.S., Clausen, J.T., Jensen, P.B., Madsen, O.D., Vrang, N., Larsen, P.J., and Hastrup, S. 1998 Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393: 72–76.

    Article  PubMed  Google Scholar 

  83. Pelleymounter, M.A., Cullen, M.J., and Wellman, C.L. 1995 Characteristics of BDNF-induced weight loss. Exp Neurol 131: 229–38.

    Article  Google Scholar 

  84. Kernie, S.G., Liebl, D.J., and Parada, L.F. 2000 BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19: 1290–300.

    Article  PubMed  Google Scholar 

  85. Prima, V., Tennant, M., Gorbatyuk, O.S., Muzyczka, N., Scarpace, P.J., and Zolotukhin, S. 2004 Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: microarray deoxyribonucleic acid-chip analysis of gene expression. Endocrinology 145: 2035–45.

    Article  PubMed  Google Scholar 

  86. Mattson, M.P. 2001 Lose weight STAT: CNTF tops leptin. Trends Neurosci 24: 313–4.

    Article  Google Scholar 

  87. Duff, E., Li, C.L., Hartzell, D.L., Choi, Y.H., Della-Fera, M.A., and Baile, C.A. 2004 Ciliary neurotrophic factor injected icv induces adipose tissue apoptosis in rats. Apoptosis 9: 629–34.

    Article  PubMed  Google Scholar 

  88. Anderson, K.D., Lambert, P.D., Corcoran, T.L., Murray, J.D., Thabet, K.E., Yancopoulos, G.D., and Wiegand, S.J. 2003 Activation of the hypothalamic arcuate nucleus predicts the anorectic actions of ciliary neurotrophic factor and leptin in intact and gold thioglucose-lesioned mice. J Neuroendocrinol 15: 649–60.

    Article  PubMed  Google Scholar 

  89. Beretta, E., Dhillon, H., Kalra, P.S., and Kalra, S.P. 2002 Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods. Peptides 23: 975–84.

    Article  PubMed  Google Scholar 

  90. Levi, A., Ferri, G.L., Watson, E., Possenti, R., and Salton, S.R. 2004 Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor. Cell Mol Neurobiol 24: 517–33.

    Article  PubMed  Google Scholar 

  91. Salton, S.R. 2003 Neurotrophins, growth-factor-regulated genes and the control of energy balance. Mt Sinai J Med 70: 93–100.

    PubMed  Google Scholar 

  92. Leibowitz, S.F., and Wortley, K.E. 2004 Hypothalamic control of energy balance: different peptides, different functions. Peptides 25: 473–504.

    Article  Google Scholar 

  93. Temoshok, L.R., and Wald, R.L. 2002 Change is complex: rethinking research on psychosocial interventions and cancer. Integr Cancer Ther 1: 135–45.

    Article  PubMed  Google Scholar 

  94. Ben-Eliyahu, S. 2003 The promotion of tumor metastasis by surgery and stress: immunological basis and implications for psychoneuroimmunology. Brain Behav Immun 17Suppl 1: S27–36.

    Article  PubMed  Google Scholar 

  95. Strange, K.S., Kerr, L.R., Andrews, H.N., Emerman, J.T., and Weinberg, J. 2000 Psychosocial stressors and mammary tumor growth: an animal model. Neurotoxicol Teratol. 2000 Jan–Feb;22(1):89–102.

    Article  PubMed  Google Scholar 

  96. Stefanski, V., and Ben-Eliyahu, S. 1996 Social confrontation and tumor metastasis in rats: Defeat and ß—adrenergic mechanisms. Physiol Behav 60: 277–282.

    Article  PubMed  Google Scholar 

  97. Temoshock, L., Peeke, H.V.S., and Mehard, C.W 1988 Individual behaviour differences related to induced tumor growth in the female syrian hamster: two studies. Int. J. Neurosci 38: 199–209.

    PubMed  Google Scholar 

  98. Stevenson, J.A., Box, B.M., and Wright, R.B. 1963 The effect of a cold environment on malignant anorexia. Can J Biochem Physiol 41: 531–2.

    PubMed  Google Scholar 

  99. Thompson, C.I., Margules, D.L., Kreider, J.W., Boha, S.P., Rejer, R.E. Jr, Quirey, R.A., and Reitz, J.A. 1993 Propensity to form conditioned taste aversions augments anorexia in obese (ob/ob) mice with B16 melanoma. Behav Neurosci 107: 786–98.

    Article  PubMed  Google Scholar 

  100. Norton, J.A., Moley, J.F., Green, M.V., Carson, R.E., and Morrison, S.D. 1985 Parabiotic transfer of cancer anorexia/cachexia in male rats. Cancer Res 45: 5547–52.

    PubMed  Google Scholar 

  101. Illig, K.A., Maronian, N., and Peacock, J.L. 1992 Cancer cachexia is transmisible in plasma J Surg Res 52: 353–358.

    Google Scholar 

  102. Donovan, H. 1954 Malignant cachexia. Proc R Soc Med 47: 27–31.

    PubMed  Google Scholar 

  103. McDonald, D.M., and Choyke, P.L. 2003 Imaging of angiogenesis: from microscope to clinic. Nat Med 9: 713–25.

    Article  PubMed  Google Scholar 

  104. Måseide, K., Kalliomäki, T., and Hill, R.P. Microenvironmental Effects on Tumour Progression and Metastasis. Chapter in this book.

    Google Scholar 

  105. Mulligan, H.D., and Tisdale, M.J. 1991 Metabolic substrate utilization by tumour and host tissues in cancer cachexia. Biochem J 277: 321–6.

    PubMed  Google Scholar 

  106. Svaninger, G., Gelin, J., and Lundholm, K. 1989 The cause of death in non-metastasizing sarcoma-bearing mice. A study with relevance for tumor treatment experiments in mice. Eur J Cancer Clin Oncol 25: 1295–302.

    Article  PubMed  Google Scholar 

  107. Ritter, S., Dinh, T.T., and Zhang, Y. 2000 Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res 856: 37–47.

    Article  PubMed  Google Scholar 

  108. Ritter, S., Bugarith, K., and Dinh, T.T. 2001 Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation. J Comp Neurol 432: 197–216.

    Article  PubMed  Google Scholar 

  109. Veech, R.L. 2004 The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids. 2004 70: 309–19.

    Article  PubMed  Google Scholar 

  110. Beck, S.A., and Tisdale, M.J. 1989 Nitrogen excretion in cancer cachexia and its modification by a high fat diet in mice. Cancer Res 49: 3800–4.

    PubMed  Google Scholar 

  111. Tisdale, M.J., Brennan, R.A., and Fearon, K.C. 1987 Reduction of weight loss and tumour size in a cachexia model by a high fat diet. Br J Cancer 56: 39–43.

    PubMed  Google Scholar 

  112. Fearon, K.C., Borland, W., Preston, T., Tisdale, M.J., Shenkin, A., and Calman, K.C. 1988 Cancer cachexia: influence of systemic ketosis on substrate levels and nitrogen metabolism. Am J Clin Nutr 47: 42–8.

    PubMed  Google Scholar 

  113. Fearon, K.C. 1988 Nutritional pharmacology in the treatment of neoplastic disease. Baillieres Clin Gastroenterol 2: 941–9.

    Article  PubMed  Google Scholar 

  114. Tisdale, M.J., and Brennan, R.A. 1988 A comparison of long-chain triglycerides and medium-chain triglycerides on weight loss and tumour size in a cachexia model. Br J Cancer 58: 580–3.

    PubMed  Google Scholar 

  115. Beck, S.A., and Tisdale, M.J. 1989 Effect of insulin on weight loss and tumour growth in a cachexia model. Br J Cancer 59: 677–81.

    PubMed  Google Scholar 

  116. Nebeling, L.C., and Lerner, E. 1995 Implementing a ketogenic diet based on medium-chain triglyceride oil in pediatric patients with cancer. J Am Diet Assoc 95: 693–7.

    Article  PubMed  Google Scholar 

  117. Wang, H.Y., Hochwald, S., Port, J., Harrison, L.E., Ng, B., and Burt, M. 1995 Hypoglycemia with glycerol salvage: a role in anti-neoplastic therapy? Anticancer Res 15: 1343–8.

    PubMed  Google Scholar 

  118. Bozzetti, F., Gavazzi, C., Mariani, L., and Crippa, F. 2004 Glucose-based total parenteral nutrition does not stimulate glucose uptake by humans tumours. Clin Nutr 23: 417–21.

    Article  PubMed  Google Scholar 

  119. Freitas, J.J., Pompeia, C., Miyasaka, C.K., and Curi, R. 2001 Walker-256 tumor growth causes oxidative stress in rat brain. J Neurochem 77: 655–63.

    Article  PubMed  Google Scholar 

  120. Zaleska, M.M., and Floyd, R.A. 1985 Regional lipid peroxidation in rat brain in vitro: possible role of endogenous iron. Neurochem Res 10: 397–410.

    Article  PubMed  Google Scholar 

  121. Theologides, A., Ingersoll-Stroubos, A.M., and Apple, F.S. 1994 TNF-alpha effect on oxygen free radical scavenging and generating enzymes in rat liver. Biochem Mol Biol Int 33: 205–10.

    PubMed  Google Scholar 

  122. Nadeau, S., and Rivest, S. 1999 Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier. Neuroscience 93: 1449–64.

    Article  PubMed  Google Scholar 

  123. Smythies, J., and Galzigna, L. 1998 The oxidative metabolism of catecholamines in the brain: a review. Biochim Biophys Acta 1380: 159–62.

    PubMed  Google Scholar 

  124. Chen, K.B., Lin, A.M., and Chiu, T.H. 2003 Oxidative injury to the locus coeruleus of rat brain: neuroprotection by melatonin. J Pineal Res 35: 109–17.

    Article  PubMed  Google Scholar 

  125. Kishi, T., Hirooka, Y., Kimura, Y., Ito, K., Shimokawa, H., and Takeshita, A. 2004 Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats. Circulation 109: 2357–62.

    Article  Google Scholar 

  126. Ramos, E.J., Suzuki, S., Marks, D., Inui, A., Asakawa, A., and Meguid, M.M. 2004 Cancer anorexia-cachexia syndrome: cytokines and neuropeptides. Curr Opin Clin Nutr Metab Care 7: 427–34.

    Article  PubMed  Google Scholar 

  127. Davis, M.P., Dreicer, R., Walsh, D., Lagman, R., and LeGrand, S.B. 2004 Appetite and cancer-associated anorexia: a review. J Clin Oncol 22: 1510–7.

    Article  PubMed  Google Scholar 

  128. Laviano, A., Russo, M., Freda, F., and Rossi-Fanelli, F. 2002 Neurochemical mechanisms for cancer anorexia. Nutrition 18: 100–5.

    Article  PubMed  Google Scholar 

  129. Inui, A., and Meguid, M.M. 2003 Cachexia and obesity: two sides of one coin? Curr Opin Clin Nutr Metab Care 6: 395–9.

    Article  PubMed  Google Scholar 

  130. Fanelli, F.R. and Laviano, A. Cancer anorexia: a model for the understanding and treatment of secondary anorexia. Int J Cardiology 85: 67–72.

    Google Scholar 

  131. Turrin, N.P., Ilyin, S.E., Gayle, D.A., Plata-Salaman, C.R., Ramos, E.J., Laviano, A., Das, U.N., Inui, A., and Meguid, M.M. 2004 Interleukin-1beta system in anorectic catabolic tumor-bearing rats. Curr Opin Clin Nutr Metab Care 7: 419–26.

    Article  PubMed  Google Scholar 

  132. Inui, A. 1999 Cancer anorexia-cachexia syndrome: are neuropeptides the key? Cancer Res 59: 4493–501.

    PubMed  Google Scholar 

  133. Inui, A. 1999 Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders? Mol Med Today 5: 79–85.

    Article  PubMed  Google Scholar 

  134. Wisse, BE., Schwartz M.W., and Cummings, D.E. 2003 Melanocortin signaling and anorexia in chronic disease states. Ann N Y Acad Sci 994: 275–81.

    PubMed  Google Scholar 

  135. Chance, W.T., Balasubramaniam, A., and Fischer, J.E. 1995 Neuropeptide Y and the development of cancer anorexia. Ann Surg 221: 579–87.

    PubMed  Google Scholar 

  136. Norton, J.A., Peacock, J.L., and Morrison, S.D. 1987 Cancer cachexia. Crit Rev Oncol Hematol 7: 289–327.

    PubMed  Google Scholar 

  137. Chance, W. T., Balasubramaniam, A., Sheriff, S., and Fischer, J. E. 1994 Possible role of neuropeptide Y in experimental cancer anorexia. Pp 185–201 in: Jacobs, M., ed. Diet and cancer: Markers, prevention and treatment. New York: Plenum Press.

    Google Scholar 

  138. Makarenko, I.G., Meguid, M.M., Gatto, L., Chen, C., and Ugrumov, M.V. 2003 Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexia. Brain Res 961: 100–8.

    Article  PubMed  Google Scholar 

  139. Chance, W.T., Balasubramaniam, A., Thompson, H., Mohapatra, B., Ramo, J., and Fischer, J.E. 1996 Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuropeptide Y. Peptides 17: 797–801.

    Article  PubMed  Google Scholar 

  140. Chance, W.T., Balasubramaniam, A., Borchers, M., and Fischer, J.E. 1995 Refractory hypothalamic adenylate cyclase in anorectic tumor-bearing rats: implications for NPY-induced feeding. Brain Res 691: 180–4.

    Article  PubMed  Google Scholar 

  141. Meguid, M.M., Ramos, E.J., Laviano, A., Varma, M., Sato, T., Chen, C., Qi, Y., and Das, U.N. 2004 Tumor anorexia: effects on neuropeptide Y and monoamines in paraventricular nucleus. Peptides 25: 261–6.

    Article  PubMed  Google Scholar 

  142. Chance, W.T., Balasubramaniam, A., Dayal, R., Brown, J., and Fischer, J.E. 1994 Hypothalamic concentration and release of neuropeptide Y into microdialysates is reduced in anorectic tumor-bearing rats. Life Sci 54: 1869–74.

    Article  PubMed  Google Scholar 

  143. Ramos, E.J., Suzuki, S., Meguid, M.M., Laviano, A., Sato, T., Chen, C., and Das, U. 2004 Changes in hypothalamic neuropeptide Y and monoaminergic system in tumor-bearing rats: pre-and post-tumor resection and at death. Surgery 136: 270–6.

    Article  PubMed  Google Scholar 

  144. McCarthy, H.D., McKibbin, P.E., Perkins, A.V., Linton, E.A., and Williams, G. 1993 Alterations in hypothalamic NPY and CRF in anorexic tumor-bearing rats. Am J Physiol 264: E638–43.

    PubMed  Google Scholar 

  145. Nara-ashizawa, N., Tsukada, T., Maruyama, K., Akiyama, Y., Kajimura, N., and Yamaguchi, K. 2001 Response of hypothalamic NPY mRNAs to a negative energy balance is less sensitive in cachectic mice bearing human tumor cells. Nutr Cancer 41: 111–8.

    Article  PubMed  Google Scholar 

  146. Nara-ashizawa., N., Tsukada, T., Maruyama, K., Akiyama, Y., Kajimura, N., Nagasaki, K., Iwanaga, T., and Yamaguchi, K. 2001 Hypothalamic appetite-regulating neuropeptide mRNA levels in cachectic nude mice bearing human tumor cells. Metabolism 50: 1213–9.

    Article  PubMed  Google Scholar 

  147. Chance, W.T., Sheriff, S., Kasckow, J.W., Regmi, A., and Balasubramaniam, A. 1998 NPY messenger RNA is increased in medial hypothalamus of anorectic tumor-bearing rats. Regul Pept 75–76: 347–53.

    Article  PubMed  Google Scholar 

  148. Jensen, P.B., Blume, N., Mikkelsen, J.D., Larsen, P.J., Jensen, H.I., Holst, J.J., and Madsen, O.D. 1998 Transplantable rat glucagonomas cause acute onset of severe anorexia and adipsia despite highly elevated NPY mRNA levels in the hypothalamic arcuate nucleus. J Clin Invest 101: 503–10.

    PubMed  Google Scholar 

  149. Bing, C., Taylor, S., Tisdale, M.J., and Williams, G. 2001 Cachexia in MAC16 adenocarcinoma: suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y. J Neurochem 79: 1004–12.

    Article  PubMed  Google Scholar 

  150. Plata-Salaman, C.R., Ilyin, S.E., and Gayle, D. 1998 Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells. Am J Physiol 275: R566–73.

    PubMed  Google Scholar 

  151. Wisse, B.E., Frayo, R.S., Schwartz, M.W., and Cummings, D.E. 2001 Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology 142: 3292–301.

    Article  Google Scholar 

  152. Chance, W. T., van Lammeren, F. M., and Fischer, J. E. 1988 Feeding elicited by cholinergic and adrenergic hypothalamic stimulation of anorectic tumor-bearing rats. Pharmacol. Biochem. Behav 31: 209–213.

    Article  PubMed  Google Scholar 

  153. Liebelt, R.A., Liebelt, A.G., Johnston, H.M. 1971 Lipid mobilization and food intake in experimentally obese mice bearing transplanted tumors. Proc Soc Exp Biol Med 138: 482–90.

    PubMed  Google Scholar 

  154. Boston, B.A. 2001 Pro-opiomelanocortin and weight regulation: from mice to men. J Pediatr Endocrinol Metab 14Suppl 6: 1409–16.

    PubMed  Google Scholar 

  155. Rahmouni, K., Haynes, W.G., Morgan, D.A, and Mark A.L. 2002 Selective resistance to central neural administration of leptin in agouti obese mice. Hypertension 39: 486–90.

    Article  PubMed  Google Scholar 

  156. Fei, H., Okano, H.J., Li, C., Lee, G.H., Zhao, C., Darnell, R., and Friedman, J.M. 1997 Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A 94: 7001–5.

    Article  PubMed  Google Scholar 

  157. Anderson, K.D., Lambert, P.D., Corcoran, T.L., Murray, J.D., Thabet, K.E., Yancopoulos, G.D., and Wiegand, S.J. 2003 Activation of the hypothalamic arcuate nucleus predicts the anorectic actions of ciliary neurotrophic factor and leptin in intact and gold thioglucose-lesioned mice. J Neuroendocrinol 15: 649–60.

    Article  PubMed  Google Scholar 

  158. Hahm, S., Fekete, C., Mizuno, T.M., Windsor, J., Yan, H., Boozer, C.N., Lee, C., Elmquist, J.K., Lechan, R.M., Mobbs, C.V., and Salton, S.R. 2002 VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin-and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 22: 6929–38.

    PubMed  Google Scholar 

  159. Kalra, S.P., Bagnasco, M., Otukonyong, E.E., Dube, M.G., and Kalra, P.S. 2003 Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul Pept 111: 1–11.

    Article  Google Scholar 

  160. Stephan, F.K., and Davidson, A.J. 1998 Glucose, but not fat, phase shifts the feeding-entrained circadian clock. Physiol Behav 65: 277–88.

    Article  PubMed  Google Scholar 

  161. Everson, C.A., and Wehr, T.A. 1993. Nutritional and metabolic adaptations to prolonged sleep deprivation in the rat. Am J Physiol 264: R376–87.

    PubMed  Google Scholar 

  162. Hastings, M.H., and Herzog, E.D. 2004 Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei. J Biol Rhythms 19: 400–13.

    Article  PubMed  Google Scholar 

  163. Buijs, R.M., van Eden, C.G., Goncharuk, V.D., and Kalsbeek, A. 2003 The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system. J Endocrinol 177: 17–26.

    Article  PubMed  Google Scholar 

  164. Filipski, E., King, V.M., Li, X., Granda, T.G., Mormont, M.C., Claustrat, B., Hastings, M.H., and Levi, F. 2003 Disruption of circadian coordination accelerates malignant growth in mice. Pathol Biol (Paris) 51: 216–9.

    Article  PubMed  Google Scholar 

  165. Filipski, E., King, V.M., Li, X., Granda, T.G., Mormont, M.C., Liu, X., Claustrat, B., Hastings, M.H., and Levi, F. 2002 Host circadian clock as a control point in tumor progression. J Natl Cancer Inst 94: 690–7.

    PubMed  Google Scholar 

  166. Filipski, E., Delaunay, F., King, V.M., Wu, M.W., Claustrat, B., Grechez-Cassiau, A., Guettier, C., Hastings, M.H., and Francis, L. 2004 Effects of chronic jet lag on tumor progression in mice. Cancer Res 64: 7879–85.

    Article  PubMed  Google Scholar 

  167. Csernus, V., and Mess, B. 2003 Biorhythms and pineal gland. Neuro Endocrinol Lett 24: 404–11.

    PubMed  Google Scholar 

  168. Simonneaux, V., and Ribelayga, C. 2003 Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 55: 325–95.

    Article  PubMed  Google Scholar 

  169. Morgan, P.J., Ross, A.W., Mercer, J.G., and Barrett, P. 2003 Photoperiodic programming of body weight through the neuroendocrine hypothalamus. J Endocrinol 177: 27–34.

    Article  PubMed  Google Scholar 

  170. Barrenetxe, J., Delagrange, P., and Martinez, J.A. 2004 Physiological and metabolic functions of melatonin. J Physiol Biochem 60: 61–72.

    PubMed  Google Scholar 

  171. Sanchez-Barcelo, E.J., Cos, S., Fernandez, R., and Mediavilla, M.D. 2003 Melatonin and mammary cancer: a short review. Endocr Relat Cancer 10: 153–9.

    Article  PubMed  Google Scholar 

  172. Blask, D.E., Dauchy, R.T., Sauer, L.A., Krause, J.A., and Brainard, G.C. 2002 Light during darkness, melatonin suppression and cancer progression. Neuro Endocrinol Lett 23Suppl 2: 52–6.

    PubMed  Google Scholar 

  173. Lissoni, P. 2002 Is there a role for melatonin in supportive care? Support Care Cancer 10: 110–6.

    Article  PubMed  Google Scholar 

  174. Karasek, M., and Pawlikowski, M. 1999 Pineal gland, melatonin and cancer. NEL Review. Neuro Endocrinol Lett 20: 139–144.

    Google Scholar 

  175. Sauer, L.A., Dauchy, R.T., and Blask, D.E. 2001 Polyunsaturated fatty acids, melatonin, and cancer prevention. Biochem Pharmacol 61: 1455–62.

    Article  PubMed  Google Scholar 

  176. Blask, D.E., Sauer, L.A., and Dauchy, R.T. 2002 Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr Top Med Chem 2: 113–32.

    Article  Google Scholar 

  177. El-Domeiri, A.A., and Das Gupta, T.K. 1976 The influence of pineal ablation and administration of melatonin on growth and spread of hamster melanoma. J Surg Oncol 8: 197–205.

    PubMed  Google Scholar 

  178. Catrina, S.B., Curca, E., Catrina, A.I., Radu, C., and Coculescu, M. 2002 Melatonin shortens the survival rate of Ehrlich ascites-inoculated mice. Neuro Endocrinol Lett 22: 432–4.

    Google Scholar 

  179. Collins, A., Yuan, L., Kiefer, T.L., Cheng, Q., Lai, L., and Hill, S.M. 2003 Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. Cancer Lett 189: 49–57.

    Article  PubMed  Google Scholar 

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  1. Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164-6520, USA

    Michael F. Wiater

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  1. Washington State University, Pullman, WA, USA

    Gary G. Meadows

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Wiater, M.F. (2005). Energy Homeostasis and the Tumor/Host Interaction: The role of the Brain. In: Meadows, G.G. (eds) Integration/Interaction of Oncologic Growth. Cancer Growth and Progression, vol 15. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3414-8_14

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