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Influence of the Bone Microenvironment on Breast Cancer Metastasis to Bone

  • Chapter
Integration/Interaction of Oncologic Growth

Part of the book series: Cancer Growth and Progression ((CAGP,volume 15))

Abstract

Cancer patients do not generally die as a direct consequence of the primary tumour, but due to the formation of secondary tumours — metastases — that arise during tumour progression. Bone metastases are a common complication in patients with advanced breast and prostate cancer. Once established, bone metastases cause intractable pain, hypocalcaemia, spinal cord compression and bone frailty. The mechanisms regulating sitespecific metastasis are not well understood despite being the focus of research for over a century. However, it is becoming clear that the microenvironment at the secondary tumour site contributes to metastatic progression by regulating the properties of metastatic cells. The stromal microenvironment provides an opportunistic niche in which circulating tumour cells can evade the immune system and be refractory to conventional therapies. A better understanding of tumour-stroma interactions may identify critical factors regulating metastatic progression and lead to the development of stromal therapies for breast and other malignancies. Here, the evidence implicating stromal factors in the metastasis of breast tumours to bone will be reviewed.

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  1. Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia, 3002

    B.L. Eckhardt, N. Pouliot & R.L. Anderson

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  2. N. Pouliot
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  1. Washington State University, Pullman, WA, USA

    Gary G. Meadows

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Eckhardt, B., Pouliot, N., Anderson, R. (2005). Influence of the Bone Microenvironment on Breast Cancer Metastasis to Bone. In: Meadows, G.G. (eds) Integration/Interaction of Oncologic Growth. Cancer Growth and Progression, vol 15. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3414-8_8

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