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Breast Cancer Patients: Diagnostic Epigenetic Markers in Blood

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Methods of Cancer Diagnosis, Therapy and Prognosis

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 1))

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Epigenetic changes are defined as changes of gene expression without changes in the DNA sequence. Both DNA methylation and histone modifications are essential in normal mammalian development. Recently, it has been shown that epigenetic alterations play an important role in tumorigenesis and represent alternative means of activation of tumor oncogenes, inactivation of tumor suppressor genes, and induction of genomic instability (Jones and Baylin, 2007). During the last 2 decades, much effort has been focused on the role of DNA methylation changes in cancer development and their utilities in cancer detection. It is now clear that histone modifications are an integral part of the epigenetic programming.

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Authors and Affiliations

  1. Department of Pathology, School of Medicine, University of Washington, Box 358050, 815 Mercer St., Seattle, WA, 98109

    Qinghua Feng & Nancy B. Kiviat

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  1. Qinghua Feng
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  2. Nancy B. Kiviat
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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Union, NJ, USA

    M. A. Hayat

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Feng, Q., Kiviat, N.B. (2008). Breast Cancer Patients: Diagnostic Epigenetic Markers in Blood. In: Hayat, M.A. (eds) Methods of Cancer Diagnosis, Therapy and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8369-3_11

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  • DOI: https://doi.org/10.1007/978-1-4020-8369-3_11

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