The theory that tumor growth is dependent upon angiogenesis started with the works of Folkman in the 1970s (Folkman, 1971). Since then, research activities in this field have led to the discovery of cellular markers and mediators associated with angiogenesis. One such family of markers is the integrin proteins (Tamkun et al., 1986), the structure and functions of which have been the subject of numerous publications, totaling in excess of 35,000 hits in PubMed.
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Bach-Gansmo, T., Tobin, D. (2008). Breast Cancer: Detection by In-Vivo Imaging of Angiogenesis. In: Hayat, M.A. (eds) Methods of Cancer Diagnosis, Therapy and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8369-3_4
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