Recent technological advancements and methodologies have been developed to perform global analysis of tissue-specific ‘signatures’ of microRNAs in humans. The emerging view from such studies is that altered miRNA expression commonly occurs in a variety of cancers, which underscores the potential utility of miRNA profiling for diagnostic and prognostic applications. We present here a high-throughput methodology for miRNA profiling that is sufficiently sensitive for routine use on clinical specimens with limited starting material.
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Mattie, M.D., Getts, R.C. (2008). Breast and Prostate Biopsies: Use of Optimized High-Throughput MicroRNA Expression for Diagnosis (Methodology). In: Hayat, M.A. (eds) Methods of Cancer Diagnosis, Therapy and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8369-3_5
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DOI: https://doi.org/10.1007/978-1-4020-8369-3_5
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