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PET/CT for Interventional Use

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Intraoperative Imaging and Image-Guided Therapy

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Abstract

We believe that image-guided therapy is slowly but surely moving into a new phase: molecular imaging (MI)-guided therapy. MI-guided surgeries and interventions require validated MI imaging agents, and the presence of a PET/CT system in the AMIGO suite gives us a unique platform for in vivo human validation of these agents, at present primarily for brain and prostate cancer but eventually for other malignancies. Multiple pathological samples from open brain surgery or prostate biopsies will be acquired and compared to PET data from corresponding image locations. Very precise mapping of sampling sites to image locations will be possible. This capability will make possible the much-needed translational steps for the validation of new tumor localizing and characterizing MI agents. Accurately defined tumor extent can guide the radiologist or interventional radiologist to achieve full or maximal resection or ablation. Using this technology, physicians can localize and target viable tumor tissue before the procedures and ensure the complete removal or destruction of tumors by visualizing any residual cancer tissue before concluding the procedure. The combined use of MRI and CT with PET enables clinicians to integrate anatomical, functional, and metabolic information to guide their decision-making during tumor resections and percutaneous thermal ablations.

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Authors and Affiliations

  1. Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA

    Marie Foley Kijewski ScD

  2. National Center for Image Guided Therapy, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Clare M. C. Tempany MD, Alexandra J. Golby MD & Ferenc A. Jolesz MD

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  1. Marie Foley Kijewski ScD
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  2. Clare M. C. Tempany MD
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  3. Alexandra J. Golby MD
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  4. Ferenc A. Jolesz MD
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Corresponding author

Correspondence to Ferenc A. Jolesz MD .

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Editors and Affiliations

  1. National Center for Image Guided Therapy, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Ferenc A. Jolesz

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Kijewski, M.F., Tempany, C.M.C., Golby, A.J., Jolesz, F.A. (2014). PET/CT for Interventional Use. In: Jolesz, F. (eds) Intraoperative Imaging and Image-Guided Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7657-3_15

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  • DOI: https://doi.org/10.1007/978-1-4614-7657-3_15

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7656-6

  • Online ISBN: 978-1-4614-7657-3

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