Abstract
Polymeric controlled drug delivery systems have emerged as important pharmaceutical dosage forms because it was recognized that drug delivery affords many medical and commercial advantages. Also, advances in polymer science and technology have enabled the economic manufacture and reproducible performance characteristics of drug devices. This paper provides an overview of oral controlled-release dosage forms: their rationale, principles governing their design and development, technologies available for drug delivery and their selection, and physiochemical principles governing the kinetics of drug release. Polymers studied for drug delivery applications and their selection, approaches to achieve constant release rates, and commercially important controlled drug delivery devices are discussed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
References
J. P. Skelly, G. L. Amidon, W. H. Barr, L. Z. Benet, J. E. Carter, J. R. Robinson, V. P. Shah and A. Yacobi, Int. J. Pharm., 63, 83–93 (1990). “Reporting on the workshop on: in vitro and in vivo testing and correlation for oral controlled/modified release dosage forms.”
J. R. Cardinal, et al., 2nd AAPS National Meeting, Boston, MA (June 1987). “Geometric approaches to constant rate controlled release drug delivery systems.”
Additional Reading
J. R. Robinson, Ed., “Sustained and Controlled Release Drug Delivery Systems,” Marcel Dekker, Inc., New York, 1978.
A. G. Thombre and J. R. Cardinal, in “Encyclopedia of Pharmaceutical Technology,” James Swarbrick and James C. Boylan, Eds., Vol. 2, Marcel Dekker, Inc., 1990, pp. 61–88. “Biopolymers for Controlled Drug Delivery.”
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Thombre, A.G. (1991). Polymeric Controlled Drug Delivery Systems: Rational Design and Development. In: Gebelein, C.G., Cheng, T.C., Yang, V.C. (eds) Cosmetic and Pharmaceutical Applications of Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3858-5_16
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3858-5_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6722-2
Online ISBN: 978-1-4615-3858-5
eBook Packages: Springer Book Archive