Skip to main content
SpringerLink
Log in

Angiotensin as a Determinant of Renal Perfusion and Function

  • Chapter
Captopril and Hypertension

Part of the book series: Topics in Cardiovascular Disease ((TCAD))

  • 79 Accesses

Abstract

Investigation of the renin-angiotensin system has focused primarily on control of blood pressure and hypertension on the one hand, and sodium homeostasis via angiotensin’s control of aldosterone release on the other. A number of lines of evidence have accumulated over the last decade which point to a central role for angiotensin in the normal control of the renal cir-culation19,49,90,96 and in the pathogenesis of a variety of diseases that involve the kidney. Indeed, a compelling argument can be made for assigning a primal function of renin and angiotensin II to control of renal circulation early during phylogeny, with the other influences of angiotensin on blood pressure and on the adrenal gland arising later.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Aiken JW, Vane JR: Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin. J Pharmacol Exp Ther 181:678–687, 1973.

    Google Scholar 

  2. Anderson RJ, Taher S, Cronin RE, McDonald KM, Schrier RW: Effect of β-adrenergic blockade and inhibitors of angiotensin II and prostaglandins on renal autoregulation. Am J Physiol 229:731–736, 1975.

    PubMed  CAS  Google Scholar 

  3. Aukland K: Effect of adrenaline, noreadrenaline, angiotensin and renal nerve stimulation on intrarenal distribution of blood flow in dogs. Acta Physiol Scand 72:498, 1968.

    Article  PubMed  CAS  Google Scholar 

  4. Aurell M: Renal response in man to plasma volume expansion and angiotensin. Scand J Clin Lab Invest 24(suppl 112):1–59, 1969.

    Google Scholar 

  5. Bailie MD Barbour JA: Effect of inhibition of peptidase activity on distribution of intrarenal blood flow. Am J Physiol 228:850–853, 1975.

    PubMed  Google Scholar 

  6. Bailie MD, Loutzenhiser R, Moyer S: Relation of renal hemodynamics to angiotensin II in renal hilar lymph of the dog. Am J Physiol 222:1075–1078, 1972.

    PubMed  CAS  Google Scholar 

  7. Bailie MD, Rector FC Jr., Seldin DW: Angiotensin II in arterial and renal venous plasma and renal lymph in the dog. J Clin Invest 50:119–126, 1971.

    Article  PubMed  CAS  Google Scholar 

  8. Barajas L: Anatomical considerations in the control of renal secretion, in Assaykeen TA (ed): Control of Renin Secretion. New York, Plenum Press, 1972, pp 1–16.

    Google Scholar 

  9. Barger AC: Renal hemodynamic factors in congestive heart failure. Ann NY Acad Sci 139:273–284, 1966.

    Article  Google Scholar 

  10. Barger AC, Herd JA: The renal circulation. N EnglJ Med 284:482–490, 1971.

    Article  CAS  Google Scholar 

  11. Baylis C, Shinagawa L, Wilson CB, Brenner BM: A relationship between systemic protein concentration and glomerular capillary ultrafiltration coefficient. Fed Proc 35:542, 1976.

    Google Scholar 

  12. Becker CG: Demonstration of actomyosin in mesangial cells of the renal glomerulus. Circulation 14:11–66, 1971.

    Google Scholar 

  13. Bern HA: Hormones and endocrine glands of fishes. Science 158:455–462, 1967.

    Article  PubMed  CAS  Google Scholar 

  14. Bernik MB: Contractile activity of human glomeruli in culture. Nephron 6:1, 1969.

    Article  PubMed  CAS  Google Scholar 

  15. Blantz RC: Effect of manitol on glomerular ultrafiltration in the hydropenic rat. J Clin Invest 54:1135–1143, 1974.

    Article  PubMed  CAS  Google Scholar 

  16. Blantz RC, Konnen KS, Tucker BJ: Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat. J Clin Invest 57:419–434, 1976.

    Article  PubMed  CAS  Google Scholar 

  17. Bock KD, Krecke HJ: Die Wirkung von synthetischem Hypertensin II auf die PAH-und Inulin-clearance, die renale Hamodynamik und die Diurese beim Menschen. Klin Wochnschr 36:69, 1958.

    Article  CAS  Google Scholar 

  18. Boyer CS: The vascular pattern of the renal glomerulus as revealed by plastic reconstruction from serial sections. Anat Rec 125:443–440, 1956.

    Article  Google Scholar 

  19. Brown JJ, Chinn RH, Gavras H, Leckie B, Lever AF, McGregor J, Morton J, Robertson JIS: Renin and renal function, in Genest J, Koiw E (eds) Hypertension ’72, Berlin, Springer-Verlag, 1972, pp 81–97.

    Google Scholar 

  20. Brown JJ, Peart WS: The effect of angiotensin on urine flow and electrolyte excretion in hypertensive patients. Clin Sci 22:1–17, 1962.

    PubMed  CAS  Google Scholar 

  21. Brunner HR, Chang P, Wallach R, Sealey JE, Laragh JH: Angiotensin II vascular receptors: Their avidity in relationship to sodium balance, the autonomic nervous system, and hypertension. J Clin Invest 51:58–67, 1972.

    Article  PubMed  CAS  Google Scholar 

  22. Bulger RE, Trump BF: Ultrastructure of granulated arteriolar cells (juxtaglomerular cells) in kidney of a fresh and a salt water teleost. Am J Anat 124:77–88, 1969.

    Article  PubMed  CAS  Google Scholar 

  23. Burger BM, Hopkins T, Tulloch A, Hollenberg NK: The role of angiotensin in the canine renal vascular response to barbiturate anesthesia. Circ Res 38:196–202, 1976.

    PubMed  CAS  Google Scholar 

  24. Caldicott WJH, Hollenberg NK, Abrams HL: Characteristics of the response of the renal vascular bed to contrast media: Evidence of vasoconstriction induced by the renin-angiotensin system. Invest Radiol 5:539–547, 1970.

    Article  PubMed  CAS  Google Scholar 

  25. Cannon PJ, Ames RP, Laragh JH: Indirect action of angiotensin infusion to inhibit tubular sodium reabsorption in dogs. Am J Physiol 211:1021–1030, 1966.

    PubMed  CAS  Google Scholar 

  26. Capelli JP, Wesson LG Jr, Aponte GE: A phylogenetic study of the renin-angiotensin system. Am J Physiol 218:1171, 1970.

    PubMed  CAS  Google Scholar 

  27. Carlson DE, Schramm LP: Renal autoregulation in the cat: Effects of angiotensin II blockade and indomethacin. Fed Proc 35:705, 1976.

    Google Scholar 

  28. Carriere S: Effect of norepinephrine, isoproterenol and adrenergic blockers upon the intrarenal distribution of blood flow. Can J Physiol Pharmacol 47:199–208, 1969.

    Article  PubMed  CAS  Google Scholar 

  29. Davis JD, Freeman RH: Mechanisms regulating renin release. Physiol Rev 56:1–56, 1976.

    PubMed  CAS  Google Scholar 

  30. DeBono E, Lee GdeJ, Mottram FR, Pickering GW, Brown JJ, Keen H, Peart WS, Sanderson PH: The action of angiotensin in man. Clin Sci 25:123–157, 1963.

    PubMed  CAS  Google Scholar 

  31. DiSalvo J, Fell C: Effects of angiotensin on canine renal blood flow. Proc Soc Exp Biol Med 133:1432, 1970.

    PubMed  CAS  Google Scholar 

  32. DiSalvo J, Peterson A, Montefusco C, Menta M: Intrarenal conversion of angiotensin I to angiotensin II in the dog. Circ Res 29:398–406, 1971.

    CAS  Google Scholar 

  33. Eide I, Loyning E, Aars H, Akre S: Autoregulation of renal blood flow in rabbits immunized with angiotensin II. Scand J Clin Lab Invest 31:123–127, 1973.

    Article  PubMed  CAS  Google Scholar 

  34. Eide I, Loyning E, Kiil F: Evidence for hemodynamic autoregulation of renin release. Circ Res 32:237–245, 1973.

    PubMed  CAS  Google Scholar 

  35. Epstein M, Berke DP, Hollenberg NK, Adams DF, Chalmers TC, Abrams HL, Merrill JP: Renal failure in the patient with cirrhosis: The role of active vasoconstriction. Am J Med 49:175–185, 1970.

    Article  PubMed  CAS  Google Scholar 

  36. Finnerty FA: Hemodynamics of angiotensin in man. Circulation 25:255–258, 1962.

    PubMed  CAS  Google Scholar 

  37. Freeman RH, Davis JO, Spielman WS, Lohmeier TE: High-output heart failure in the dog: Systemic and intrarenal role of angiotensin II. Am J Physiol 229:474–478, 1975.

    PubMed  CAS  Google Scholar 

  38. Freeman RH, Davis JO, Vitale SJ, Johnson JA: Intrarenal role of angiotensin II. Circ Res 32:692–698, 1973.

    PubMed  CAS  Google Scholar 

  39. Frega N, Guerther B, Dibona D, Leaf A: The role of angiotensin II in the impaired reflow following hemorrhagic hypotension. Am Soc Nephrol 6:37, 1973.

    Google Scholar 

  40. Furuyama T, Suzuki C, Shioji R, Saito H, Maebashi M, Aida M: Effect of angiotensin on renal function of the dog. Tohoku J Exp Med 92:73–81, 1967.

    Article  PubMed  CAS  Google Scholar 

  41. Gagnon JC, Rice MK, Flamenbaum W: Effect of angiotensin converting enzyme inhibition on renal autoregulation. Proc Soc Exp Biol Med 146:414–418, 1974.

    PubMed  CAS  Google Scholar 

  42. Gassee JP, Decoodt P, Verniory A, Lambert PP: Autoregulation of effective glomerular filtration pressure. J Physiol (Lond) 226:616–623, 1974.

    CAS  Google Scholar 

  43. Gertz KH, Mangos JA, Braun G, Pagel HD: Pressure in the glomerular capillaries of the rat kidney and its relation to arterial pressure. PflĂĽgers Arch 288:369, 1966.

    Article  CAS  Google Scholar 

  44. Goormaghtigh N: La doctrine de la cellule musculaire affibrillaire endocrine en pathologie humaine. Le rein de l’eclampsie puerpuale. Bull Acad R Med Belg 7:194, 1942.

    Google Scholar 

  45. Granger P, Dahlheim H, Thurau K: Enzyme activities of the single juxtaglomerular apparatus in the rat kidney. Kidney Internat 1:78–88, 1972.

    Article  CAS  Google Scholar 

  46. Gutman RA, Forrey AW, Fleet WP, Cutler RE: Vasopressor-induced natriuresis and altered intrarenal haemodynamics in cirrhotic man. Clin Sci Mol Med 45:19–34, 1973.

    CAS  Google Scholar 

  47. Hall BV, Roth LE: Preliminary studies on the development and differentiation of cells and structures of the renal corpuscle. Proc Stockholm Conference on Electron Microscopy, pp 176–179, 1956.

    Google Scholar 

  48. Hall JE, Guyton AC, Trippodo NC, Lohmeier TE, McCaa RE, Cowley AW: Intrarenal control of electrolyte excretion by angiotensin II. Am J Physiol 232:F538–F544, 1977.

    PubMed  CAS  Google Scholar 

  49. Hollenberg NK: The physiology of the renal circulation, in Renal Disease, Fourth Edition (Black, D, Jones NF, eds) Oxford, Blackwell Scientific Publications, chap 2.

    Google Scholar 

  50. Hollenberg NK, Adams DF, Rashid A, Epstein M, Abrams HL, Merrill JP: The renal vascular response to salt restriction in norman man: Evidence against adrenergic mediation. Circulation 43:845–851, 1971.

    PubMed  CAS  Google Scholar 

  51. Hollenberg NK, Chenitz WR, Adams DF, Williams GH: Reciprocal influence of salt intake on adrenal glomerulosa and renal vascular responses to angiotensin II in normal man. J Clin Invest 54:34–42, 1974.

    Article  PubMed  CAS  Google Scholar 

  52. Hollenberg NK, Epstein M, Basch RI, Merrill JP, Hickler RB: Renin secretion in the patient with hypertension: Relationship to intrarenal blood flow distribution. Circ Res 14:113–122, 1969.

    Google Scholar 

  53. Hollenberg NK, Solomon HS, Adams DF, Abrams HL, Merrill JP: Renal vascular response to angiotensin and norepinephrine in normal man: The effect of salt intake. Circ Res 31:750–757, 1972.

    PubMed  CAS  Google Scholar 

  54. Hollenberg NK, Swartz SL, Passan DR, Williams GH: Increased glomerular filtration rate following converting enzyme inhibition in essential hypertension. N Engl J Med 301:9–12, 1979.

    Article  PubMed  CAS  Google Scholar 

  55. Hollenberg NK, Williams GH, Burger B, Chenitz WR, Hooshmand I, Adams DF: Renal blood flow and its response to angiotensin II: An interaction between oral contraceptive agents, sodium intake and the renin-angiotensin system in healthy young women. Circ Res 38:35–40, 1976.

    PubMed  CAS  Google Scholar 

  56. Hollenberg NK, Williams GH, Burger BM, Hooshmand I: Potassium’s influence on the renal vasculature, the adrenal and their responsiveness to angiotensin II in normal man. Clin Sci Mol Med 49:527–534, 1975.

    PubMed  CAS  Google Scholar 

  57. Hollenberg NK, Williams GH, Burger BM, Ishikawa I, Adams DF: Blockade and stimulation of renal, adrenal and vascular receptors for angiotensin II with 1-Sar, 8-Ala angiotensin II in normal man. J Clin Invest 57:39–46, 1976.

    Article  PubMed  CAS  Google Scholar 

  58. Hollenberg NK, Williams GH, Taub KJ, Ishikawa I, Brown C, Adams DF: Renal vascular response to interruption of the renin-angiotensin system in normal man. Kidney Int 12:285–293, 1977.

    Article  PubMed  CAS  Google Scholar 

  59. Hornych H, Beaufils M, Richet G: The effect of exogenous angiotensin on superficial and deep glomeruli in the rat kidney. Kidney Int 2:336–343, 1972.

    Article  PubMed  CAS  Google Scholar 

  60. Ishikawa I, Hollenberg NK: Pharmacologic interruption of the renin-angiotensin system in myohemoglobinuric acute renal failure. Kidney Int 10:S183–S190, 1976.

    Google Scholar 

  61. Jakschik BA, McKnight RC, Marshall GR, Feldhaus RA, Needleman P: Renal vascular changes during hemorrhagic shock. Circ Shock 1:231–237, 1974.

    Google Scholar 

  62. Jamison RL: Micropunture study of superficial and juxtamedullary nephrons in the rat. Am J Physiol 218:46–55, 1970.

    PubMed  CAS  Google Scholar 

  63. Kaloyanides GJ, Bastron RD, DiBona GF: Impaired autoregulation of blood flow and glomerular filtration rate in the isolated dog kidney depleted of renin. Circ Res 35:400–412, 1974.

    PubMed  CAS  Google Scholar 

  64. Kiil F: Influence of autoregulation on renin release and sodium excretion. Kidney Int 8:S208–S218, 1975.

    Google Scholar 

  65. Kiil F, Kjekshus J, Loyning E: Renal autoregulation during infusion of noradrenaline, angiotensin and acetylcholine. Acta Physiol Scand 76:10–23, 1969.

    Article  PubMed  CAS  Google Scholar 

  66. Kimbrough HM Jr, Vaughan ED Jr, Carey RM, Ayers CR: Effect of intrarenal AII blockade on renal function in dogs. Cir Res 40:174–178, 1977.

    CAS  Google Scholar 

  67. Krahe P, Hofbauer KG, Gross F: Effects of endogenous renin on the function of the isolated kidney. Life Sci 9:1317–1320, 1970.

    Article  CAS  Google Scholar 

  68. Lachance JG, Arnoux E, Brunette MG, Carriere SC: Factors responsible for the outer cortical ischemia observed during hemorrhagic hypotension in dogs. Circ Shock 1:131–144, 1974.

    Google Scholar 

  69. Laragh JH, Cannon PG, Bentzel CJ, Sicinski AM, Meltzer JI: Angiotensin II, norepinephrine and renal transport of electrolytes and water in normal man in cirrhosis with ascites. J Clin Invest 42:1179, 1963.

    Article  PubMed  CAS  Google Scholar 

  70. Leckie B, Gavras H, McGregor J, McElwee G: The conversion of angiotensin I to angiotensin II by rabbit glomeruli. J Endocrinol 55:229–230, 1972.

    Article  PubMed  CAS  Google Scholar 

  71. Lever AF: The vasa recta and countercurrent multiplication. Acta Med Scand 178:434, 1965.

    Google Scholar 

  72. Lewis OH: The vascular arrangement of the mammalian renal glomerulus as revealed by a study of its development. J Anat 92:433–440, 1958.

    PubMed  CAS  Google Scholar 

  73. Ljungqvist A: Ultrastructural demonstration of a connection between afferent and efferent juxtamedullary glomerular arterioles. Kidney Int 8:239–244, 1975.

    Article  PubMed  CAS  Google Scholar 

  74. Malvin RL, Vander AJ: Plasma renin activity in marine teleosts and cetacea. Am J Physiol 213:1582–1584, 1967.

    PubMed  CAS  Google Scholar 

  75. Mandel MJ, Sapirstein LA: Effect of angiotensin infusion on regional blood flow and regional vascular resistance in the rat. Circ Res 10:807–816, 1962.

    PubMed  CAS  Google Scholar 

  76. McGiff JC, Crowshaw K, Terragno NA, Lonigro AJ: Release of a prostaglandin-like substance into renal venous blood in response to angiotensin II. Circ Res 26–27(suppl1):I121–I130, 1970.

    Google Scholar 

  77. McGiff JCM, Fasy TM: The relationship of the renal vascular activity of angiotensin II to the autonomic nervous system. J Clin Invest 44:1911, 1965.

    Article  PubMed  CAS  Google Scholar 

  78. McGiff JC, Itskovitz HD: Loss of the renal vasoconstrictor activity of angiotensin II during renal ischemia. J Clin Invest 43:2359–2367, 1964.

    Article  PubMed  CAS  Google Scholar 

  79. Mimran A, Guiod L, Hollenberg NK: Angiotensin’s role in the cardiovascular and renal response to salt restriction. Kidney Int 5:348–355, 1974.

    Article  PubMed  CAS  Google Scholar 

  80. Myers BD, Deen WM, Breener BM: Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal tubule fluid reabsorption in the rat. Circ Res 37:101–110, 1975.

    PubMed  CAS  Google Scholar 

  81. Navar LG, Langford HG: Effects of angiotensin on the renal circulation. Angiotensin: Handbook of Experimental Pharmacology 37:455–474, 1974.

    CAS  Google Scholar 

  82. Ng KKF, Vane JR: Conversion of angiotensin I to angiotensin II. Nature 216:762–766, 1967.

    Article  PubMed  CAS  Google Scholar 

  83. Nishimura H, Ogawa M, Sawyer WH: Renin-angiotensin system in primitive bony fishes and a holocephalian. Am J Physiol 224:950–956, 1973.

    PubMed  CAS  Google Scholar 

  84. Osborne MJ, Drox B, Meyer P, Morel F: Angiotensin II: Renal localization in glomerular mesangial cells by autoradiography. Kidney Int 8:245–254, 1975.

    Article  PubMed  CAS  Google Scholar 

  85. Peart WS, Brown JJ: Effect of angiotensin (hypertensin or angiotonin) on urine flow and electrolyte excretion in hypertensive patients. Lancet 1:28–29, 1961.

    Article  PubMed  CAS  Google Scholar 

  86. Regoli D, Gauthier R: Site of action of angiotensin and other vasoconstrictors on the kidney. Can J Physiol Pharmacol 49:608–612, 1971.

    Article  PubMed  CAS  Google Scholar 

  87. Sasaki H, Okomura H, Ikeda H, Kawasaki I, Fukiyama K: Hypotensive response to angiotensin II analog in Bartter’s syndrome. N EnglJ Med 294:611–612, 1976.

    CAS  Google Scholar 

  88. Satoh S, Zimmerman BG: Effect of (Sar1-Ala8)angiotensin II on renal vascular resistance. Am J Physiol 229:640–645, 1975.

    PubMed  CAS  Google Scholar 

  89. Sawyer WH, Blair-West JR, Simpson PA, Sawyer MK: Renal responses of Australian lungfish to vasotocin, angiotensin II, and NaCl infusion. Am J Physiol 231:593–602, 1976.

    PubMed  CAS  Google Scholar 

  90. Schmid HE Jr: Renin, a physiologic regulator of renal hemodynamics. Circ Res 11:185–193, 1962.

    PubMed  CAS  Google Scholar 

  91. Schmid HE Jr: Action of angiotensin in normal, adrenalectomized, and renal hypertensive trained dogs. Nephron 5:265–281, 1968.

    Article  PubMed  Google Scholar 

  92. Schroeder ET, Anderson GH, Goldman SH, Streeten DHP: Effects of angiotensin II (AII) blockade with l-Sar-8-Ala AII (Saralasin) in patients with cirrhosis and ascites. Kidney Int 9:511–519, 1976.

    Article  PubMed  CAS  Google Scholar 

  93. Smeby RR, Bumpus FM: Renin, in Page IH, McCubbins JW (eds) Renal Hypertension, Chicago, Year Book Medical Publishers, 1968, pp 14–61.

    Google Scholar 

  94. Smith HW: Lectures on the Kidney, Lawrence, University of Kansas Press, 1943.

    Google Scholar 

  95. Smith HW: The Kidney: Structure and Function in Health and Disease. New York, Oxford University Press, 1951.

    Google Scholar 

  96. Sokabe H: Phylogeny of the renal effects of angiotensin. Kidney Int 6:263–271, 1974.

    Article  PubMed  CAS  Google Scholar 

  97. Sokabe H, Mizogame S, Sato A: Role of renin in adaptation to sea water in eruyhaline fishes. Jpn J Pharmacol 18:332–343, 1968.

    Article  PubMed  CAS  Google Scholar 

  98. Sraer JD, Sraer J, Adraillou R, Mimoune O: Evidence for renal glomerular receptors for angiotensin II. Kidney Int 6:241–246, 1974.

    Article  PubMed  CAS  Google Scholar 

  99. Swartz SL, Williams GH, Hollenberg NK, Moore TJ, Dluhy RG: Converting enzyme inhibition in essential hypertension: The hypotensive response does not reflect only reduced angiotensin II formation. Hypertension 1:106–111, 1979.

    PubMed  CAS  Google Scholar 

  100. Kaub KH, Caldicott WJH, Hollenberg NK: Identity of renal vascular receptors for angiotensin II (AII) and the 2–8 heptapeptide (AIII). Am Soc Nephrol 8:48, 1975.

    Google Scholar 

  101. Thurston H, Laragh JH: Prior receptor occupancy as a determinant of the pressor activity of infused angiotensin II in the rat. Circ Res 36:113–117, 1975.

    PubMed  CAS  Google Scholar 

  102. Vander AJ: Control of renin release. Physiol Rev 47:359, 1967.

    PubMed  CAS  Google Scholar 

  103. Villarreal H, Arcila H, Diaz J, Sierra P: Effect of angiotensin on the renal transport of sodium in essential hypertension. Circulation 35:889, 1967.

    PubMed  CAS  Google Scholar 

  104. Warren DJ, Ledingham JGG: Effects of beta adrenergic receptor blockade on the renal vascular response to a low sodium diet in the rabbit. Clin Sci Mol Med 48:533–535, 1975.

    CAS  Google Scholar 

  105. Williams GH, Hollenberg NK: Accentuated vascular and endocrine response to SQ 20,881 in hypertension. N EnglJ Med 297:184–188, 1977.

    Article  CAS  Google Scholar 

  106. Zimmerman BG: Involvement of angiotensin-mediated renal vasoconstriction in renal hypertension. Life Sci 13:507–515, 1973.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Harvard Medical School, USA

    Norman K. Hollenberg M.D., Ph.D.

  2. Renal Division, Peter Bent Brigham Hospital, Boston, Massachusetts, 02115, USA

    Norman K. Hollenberg M.D., Ph.D.

Authors
  1. Norman K. Hollenberg M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. New York Hospital/Cornell Medical Center, New York, New York, USA

    David B. Case  & John H. Laragh  & 

  2. Albert Einstein College of Medicine, The Bronx, New York, USA

    Edmund H. Sonnenblick

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Publishing Corporation

About this chapter

Cite this chapter

Hollenberg, N.K. (1980). Angiotensin as a Determinant of Renal Perfusion and Function. In: Case, D.B., Sonnenblick, E.H., Laragh, J.H. (eds) Captopril and Hypertension. Topics in Cardiovascular Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9179-5_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9179-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9181-8

  • Online ISBN: 978-1-4615-9179-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation