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Nanoparticles Against Schistosomiasis

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Nanoparticles in the Fight Against Parasites

Part of the book series: Parasitology Research Monographs ((Parasitology Res. Monogr.,volume 8))

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Abstract

Schistosomiasis is an important parasitic disease caused by trematode worms of the genus Schistosoma. Schistosomiasis control strategies are predominantly based on the treatment of infected individuals with effective drugs. Recently, nanotechnology holds promise for medication and nutrition, because materials at the nanometer dimension exhibit novel properties different from those of both isolated atoms and bulk material. Developed nanoparticles have great potential to overcome the limitations associated with products currently available in the market for the treatment of schistosomiasis. Also, the use of nanotechnology can provide a novel diagnostic assay for Schistosomasis. In this chapter, we showed our results on the effect of nanogold on the S. mansoni induced infection in the brain of mice. Neuroschistosomiasis is the infection of the central nervous system by Schistosoma spp. However, neurological complications generally occur during chronic hepatointestinal schistosomiasis. Gold nanoparticles have anti-neuroschistosomal effects and could decrease the neuro-oxidative stress and regulated the genes expression in brain of mice infected with S. mansoni.

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Authors and Affiliations

  1. Department of Zoology, College of Science, King Saud University, 2455, Riyadh, 11451, Saudi Arabia

    Mohamed A. Dkhil & Saleh Al-Quraishy

  2. Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt

    Mohamed A. Dkhil & Amira A. Bauomy

  3. Department of Graphic Design, Faculty of Architectural Engineering and Digital Design, Dar Al Uloom University, Riyadh, Saudi Arabia

    Dina A. Nafady

  4. The Higher Institute of Applied Arts, 6th of October City, Cairo, Egypt

    Dina A. Nafady

  5. Molecular Drug Evaluation Department, National Organization for Drug Control & Research (NODCAR), Giza, Egypt

    Marwa S. M. Diab

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  1. Mohamed A. Dkhil
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  2. Dina A. Nafady
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  4. Amira A. Bauomy
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  5. Saleh Al-Quraishy
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Correspondence to Mohamed A. Dkhil .

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  1. Department of Parasitology, Heinrich Heine University Department of Parasitology, Düsseldorf, Germany

    Heinz Mehlhorn

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Dkhil, M.A., Nafady, D.A., Diab, M.S.M., Bauomy, A.A., Al-Quraishy, S. (2016). Nanoparticles Against Schistosomiasis. In: Mehlhorn, H. (eds) Nanoparticles in the Fight Against Parasites. Parasitology Research Monographs, vol 8. Springer, Cham. https://doi.org/10.1007/978-3-319-25292-6_10

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