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Biosynthesis of Fungal Polyketides

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Physiology and Genetics

Part of the book series: The Mycota ((MYCOTA,volume 15))

Abstract

Fungal polyketides comprise a diverse group of secondary metabolites that play an important role for drug discovery, as pigments, and as mycotoxins. Their biosynthesis is governed by multidomain enzymes, so-called fungal type I polyketide synthases (PKS). Investigating the molecular basis of polyketide biosynthesis in fungi is of great importance for ecological and pharmacological reasons. Cloning, functional analysis and expression of fungal PKS genes also set the basis for engineering a yet largely untapped biosynthetic potential. This review summarizes the current knowledge on fungal PKS.

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  1. Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745, Jena, Germany

    Julia Schuemann & Christian Hertweck

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  1. Julia Schuemann
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  2. Christian Hertweck
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Correspondence to Christian Hertweck .

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  1. Inst. Biotechnologie und, TU Kaiserslautern, Erwin-Schrödinger-Str. 56, Kaiserslautern, 67663, Germany

    Timm Anke

  2. MIP Pharma GmbH, Mühlstr. 50, St.Ingbert, 66386, Germany

    Daniela Weber

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Schuemann, J., Hertweck, C. (2009). Biosynthesis of Fungal Polyketides. In: Anke, T., Weber, D. (eds) Physiology and Genetics. The Mycota, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00286-1_16

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