Abstract
Speculation concerning the mechanisms responsible for normal erythrocyte destruction dates back at least to Ponfick’s observations [18] of damaged cells. The systematic studies by Rous [22] clearly implied progressive intrinsic alteration of the cell as an important determinant in the normal fate of the erythrocyte and confirmed the earlier suggestion that the spleen was of particular importance in erythrocyte destruction. Currently it is considered that the normal erythrocyte’s life span is a function of time dependent changes of the erythrocyte which adversely affect its capacity to survive severe flow requirements of the microcirculation and the phagocytic elements of the reticuloendothelial system.
Supported by USPHS Research Grant AM-15148, USPHS Training Grant AM-1004, USPHS Fellowship HL-34600, by Army Contract # DA-49-193-MD-2656 and by the U.S. Atomic Energy Project at the University of Rochester. It has been assigned publication # UR-3490-460. A part of this work was presented at the II Internationales Symposium über Stoffwechsel und Membran Permeabilität von Erythrozyten, Thrombozyten und Leukozyten. Vienna, 14-16 June, 1972.
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© 1973 Masson & Cie, Editeurs, Paris
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La Celle, P.L., Kirkpatrick, F.H., Udkow, M.P., Arkin, B. (1973). Membrane Fragmentation and Ca++-Membrane Interaction : Potential Mechanisms of Shape Change in the Senescent Red Cell. In: Bessis, M., Weed, R.I., Leblond, P.F. (eds) Red Cell Shape. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88062-9_9
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DOI: https://doi.org/10.1007/978-3-642-88062-9_9
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