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Targeted and Personalized Therapy for Nonmelanoma Skin Cancers

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Personalized Treatment Options in Dermatology

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Abstract

AK lesions are caused by chronic ultraviolet radiation exposure, and the presence of two or more AK lesions along with photodamage should raise consideration of a diagnosis of field cancerization. Treatment of AK and field cancerization should be driven by consideration of relevant patient, disease, and treatment factors, and appropriate treatment decisions will differ from patient to patient.

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Abbreviations

5-FU:

5-Fluorouracil

AK:

Actinic keratosis

ALA:

5-Aminolevulinic acid

AZA:

Azathioprine

BCC:

Basal cell carcinoma

CLL:

Chronic lymphocytic leukemia

CNI:

Calcineurin inhibitors such as cyclosporin A, tacrolimus

COX-2:

Cyclooxygenase-2

CsA:

Cyclosporin A

LSRs:

Local skin reactions

MAL:

Methyl aminolevulinate

MMF:

Mycophenolate mofetil

NHL:

Non-Hodgkin lymphoma

NMSC:

Nonmelanoma skin cancer

OTR:

Organ transplant recipients

PDT:

Photodynamic therapy

RCT:

Randomized controlled trial

REAKT:

Swiss Registry of Actinic Keratosis Treatment

SA:

Salicylic acid

SCC:

Squamous cell carcinoma

UV:

Ultraviolet

UVA:

Ultraviolet-A

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Authors and Affiliations

  1. Department of Dermatology, UniversitätsSpital Zürich, Zürich, 8091, Switzerland

    Chantal C. Bachmann MD & Günther F. L. Hofbauer MD

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  1. Chantal C. Bachmann MD
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Correspondence to Günther F. L. Hofbauer MD .

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Editors and Affiliations

  1. Department of Dermatology and Allergy, Center of Translational Medicine, University of Bonn, Bonn, Germany

    Thomas Bieber

  2. St. John's Institute of Dermatology, London, United Kingdom

    Frank Nestle

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Bachmann, C.C., Hofbauer, G.F.L. (2015). Targeted and Personalized Therapy for Nonmelanoma Skin Cancers. In: Bieber, T., Nestle, F. (eds) Personalized Treatment Options in Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45840-2_3

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