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Lead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

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VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016

Part of the book series: IFMBE Proceedings ((IFMBE,volume 60))

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Abstract

Lead (Pb++) is a toxic agent that can exert adverse effects on the cardiac human health. Pb++ blocks the L-type Ca++ channels. A decrease in L-type calcium current (I CaL ) is an important mechanism favoring atrial fibrillation. It is important to study the electrophysiological Pb++ effects on the atrial action potential in healthy people and those with AF. For this, we study the consequences of Pb++ on action potential, under normal and atrial fibrillation condition using in silico models. Our results suggest that Pb++ blocks I CaL current in a fraction greater as the concentration increases, resulting in an action potential duration shortening, Pb++ has a greater action potential duration effect on control conditions. To our knowledge, this is the first work that has developed mathe-matical models of Pb++ effect on I CaL current to study its effect on human atrial action potential.

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Author information

Authors and Affiliations

  1. MATBIOM, Universidad de Medellín, Medellín, Colombia

    C. Tobón

  2. GI2B, Instituto Tecnológico Metropolitano, Medellín, Colombia

    D. Pachajoa

  3. Grupo de Dinámica Cardiovascular, Universidad Pontificia Bolivariana, Medellín, Colombia

    J. P. Ugarte

  4. CI2B, Universitat Politècnica de València, Valencia, Spain

    J. Saiz

Authors
  1. C. Tobón
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  2. D. Pachajoa
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  3. J. P. Ugarte
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  4. J. Saiz
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Corresponding author

Correspondence to C. Tobón .

Editor information

Editors and Affiliations

  1. Asociación Colombiana de Bioingeniería y Electrónica Médica - ABIOIN, Bucamaranga, Colombia

    Isnardo Torres

  2. Universidad Pontificia Bolivariana - UPB, Centro de Bioingeniería, Medellín, Colombia

    John Bustamante

  3. Universidad Industrial de Santander, Escuela de Ing. Eléctrica, Electrónica, Bucaramanga, Colombia

    Daniel A. Sierra

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Tobón, C., Pachajoa, D., Ugarte, J.P., Saiz, J. (2017). Lead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study. In: Torres, I., Bustamante, J., Sierra, D. (eds) VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016. IFMBE Proceedings, vol 60. Springer, Singapore. https://doi.org/10.1007/978-981-10-4086-3_17

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  • DOI: https://doi.org/10.1007/978-981-10-4086-3_17

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4085-6

  • Online ISBN: 978-981-10-4086-3

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