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Erschienen in: Adsorption 4/2017

14.03.2017

Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach

verfasst von: Laurent David, Jay Yun, Roger-Marc Nicoud

Erschienen in: Adsorption | Ausgabe 4/2017

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Abstract

This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized” conditions, the behavior of the real systems associated with columns of finite efficiencies are simulated with ChromWorks™ and compared. It is shown that the SMB performs better than single column elution chromatography, and that, for the application selected, ISMB and SSMB are very similar and perform better than SMB.

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Literatur
Zurück zum Zitat Agrawal, G., Kawajiri, Y.: Full superstructure for multiobjective optimization of multicolumn chromatography for ternary separations. Chem. Eng. Technol. 38, 1677–1682 (2015)CrossRef Agrawal, G., Kawajiri, Y.: Full superstructure for multiobjective optimization of multicolumn chromatography for ternary separations. Chem. Eng. Technol. 38, 1677–1682 (2015)CrossRef
Zurück zum Zitat Baudouin, S., Lancrenon, X.: Desugarization of low purity syrups and molasses: the sequential simulated moving bed (SSMB) is a new step of progress in the development of chromatographic separation for two fractions systems. In: CITS Proceedings of the 22nd general assembly of the International Commission on Sugar Technology. pp. 295–302 (2003) Baudouin, S., Lancrenon, X.: Desugarization of low purity syrups and molasses: the sequential simulated moving bed (SSMB) is a new step of progress in the development of chromatographic separation for two fractions systems. In: CITS Proceedings of the 22nd general assembly of the International Commission on Sugar Technology. pp. 295–302 (2003)
Zurück zum Zitat Biressi, G., Ludemann-Hombourger, O., Mazzotti, M., Nicoud, R.-M., Morbidelli, M.: Design and optimisation of a simulated moving bed unit: role of deviations from equilibrium theory. J. Chromatogr. A. 876, 3–15 (2000)CrossRef Biressi, G., Ludemann-Hombourger, O., Mazzotti, M., Nicoud, R.-M., Morbidelli, M.: Design and optimisation of a simulated moving bed unit: role of deviations from equilibrium theory. J. Chromatogr. A. 876, 3–15 (2000)CrossRef
Zurück zum Zitat Carta, G., Mahajan, A.I., Cohen, L.M., Byers, C.H.: Chromatography of reversibly reacting mixtures: mutarotation effects in sugar separations. Chem. Eng. Sci. 47, 1645–1657 (1992)CrossRef Carta, G., Mahajan, A.I., Cohen, L.M., Byers, C.H.: Chromatography of reversibly reacting mixtures: mutarotation effects in sugar separations. Chem. Eng. Sci. 47, 1645–1657 (1992)CrossRef
Zurück zum Zitat Charton, F., Nicoud, R.-M.: Complete design of a simulated moving bed. J. Chromatogr. A. 702, 97–112 (1995)CrossRef Charton, F., Nicoud, R.-M.: Complete design of a simulated moving bed. J. Chromatogr. A. 702, 97–112 (1995)CrossRef
Zurück zum Zitat Katsuo, S., Mazzotti, M.: Intermittent simulated moving bed chromatography: 1. Design criteria and cyclic steady-state. J. Chromatogr. A. 1217, 1217–1354 (2010a) Katsuo, S., Mazzotti, M.: Intermittent simulated moving bed chromatography: 1. Design criteria and cyclic steady-state. J. Chromatogr. A. 1217, 1217–1354 (2010a)
Zurück zum Zitat Katsuo, S., Mazzotti, M.: Intermittent simulated moving bed chromatography: 2. Separation of Troger’s base enantiomers. J. Chromatogr. A. 1217, 3067–3075 (2010b)CrossRef Katsuo, S., Mazzotti, M.: Intermittent simulated moving bed chromatography: 2. Separation of Troger’s base enantiomers. J. Chromatogr. A. 1217, 3067–3075 (2010b)CrossRef
Zurück zum Zitat Mazzotti, M., Storti, G., Morbidelli, M.: Robust design of countercurrent adsorption separation: 3. Nonstoichiometric systems. AIChE J. 42, 2784–2796 (1996)CrossRef Mazzotti, M., Storti, G., Morbidelli, M.: Robust design of countercurrent adsorption separation: 3. Nonstoichiometric systems. AIChE J. 42, 2784–2796 (1996)CrossRef
Zurück zum Zitat Nicoud, R.-M.: The amazing ability of continuous chromatography to adapt to a moving environment. Ind. Eng. Chem. Res. 53, 3755–3765 (2014)CrossRef Nicoud, R.-M.: The amazing ability of continuous chromatography to adapt to a moving environment. Ind. Eng. Chem. Res. 53, 3755–3765 (2014)CrossRef
Zurück zum Zitat Nicoud, R.-M.: Chromatographic Processes: modeling, simulation and design. Cambridge University Press, New York (2015)CrossRef Nicoud, R.-M.: Chromatographic Processes: modeling, simulation and design. Cambridge University Press, New York (2015)CrossRef
Zurück zum Zitat Ruthven, D.M., Ching, C.B.: Counter-current and simulated counter-current adsorption separation processes. Chem. Eng. Sci. 44, 1011–1038 (1989)CrossRef Ruthven, D.M., Ching, C.B.: Counter-current and simulated counter-current adsorption separation processes. Chem. Eng. Sci. 44, 1011–1038 (1989)CrossRef
Zurück zum Zitat Sainio, T.: Unified Design of chromatographic processes with timed events: Separation of ternary mixtures. Chem. Eng. Sci. 152, 547–567 (2016)CrossRef Sainio, T.: Unified Design of chromatographic processes with timed events: Separation of ternary mixtures. Chem. Eng. Sci. 152, 547–567 (2016)CrossRef
Zurück zum Zitat Siitonen, J., Sainio, T.: Unified design of chromatographic separation processes. Chem. Eng. Sci. 122, 436–451 (2015)CrossRef Siitonen, J., Sainio, T.: Unified design of chromatographic separation processes. Chem. Eng. Sci. 122, 436–451 (2015)CrossRef
Zurück zum Zitat Storti, G., Mazzotti, M., Morbidelli, M., Carrà, S.: Robust design of binary countercurrent adsorption separation processes. AIChE J. 39, 471–492 (1993)CrossRef Storti, G., Mazzotti, M., Morbidelli, M., Carrà, S.: Robust design of binary countercurrent adsorption separation processes. AIChE J. 39, 471–492 (1993)CrossRef
Zurück zum Zitat Tanimura, M., Tamura, M., Teshima, T.: Method of chromatographic separation, US Patent No. 5,064,539, 12 Nov 1991 Tanimura, M., Tamura, M., Teshima, T.: Method of chromatographic separation, US Patent No. 5,064,539, 12 Nov 1991
Zurück zum Zitat Tanimura, M., Tamura, M., Teshima, T.: Japanese Patent No. B-H07-046097, 1995 Tanimura, M., Tamura, M., Teshima, T.: Japanese Patent No. B-H07-046097, 1995
Zurück zum Zitat Zhang, Z., Mazzotti, M., Morbidelli, M.: Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon. Korean J. Chem. Eng. 21, 454–464 (2004)CrossRef Zhang, Z., Mazzotti, M., Morbidelli, M.: Continuous chromatographic processes with a small number of columns: Comparison of simulated moving bed with Varicol, PowerFeed, and ModiCon. Korean J. Chem. Eng. 21, 454–464 (2004)CrossRef
Zurück zum Zitat Zhong, G., Guiochon, G.: Analytical solution for the linear ideal model of simulated moving bed chromatography. Chem. Eng. Sci. 51, 4307–4319 (1996)CrossRef Zhong, G., Guiochon, G.: Analytical solution for the linear ideal model of simulated moving bed chromatography. Chem. Eng. Sci. 51, 4307–4319 (1996)CrossRef
Metadaten
Titel
Comparing multi-column chromatographic processes for purifying monosaccharides part I: A simplified approach
verfasst von
Laurent David
Jay Yun
Roger-Marc Nicoud
Publikationsdatum
14.03.2017
Verlag
Springer US
Erschienen in
Adsorption / Ausgabe 4/2017
Print ISSN: 0929-5607
Elektronische ISSN: 1572-8757
DOI
https://doi.org/10.1007/s10450-017-9878-1

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