In previous investigations chromates were proven to be highly toxic for different cell systems of rat and human origin (Popper et al., 1990). In addition it causes severe organ injury in the respiratory and alimentary tract and in the spleen (see Popper et al., this volume). Different chromates and especially water soluble dichromates exert their toxic effects on mammalian cell systems at least in part by the liberation of oxygen radicals (Popper, Woldrich, 1991). Our knowledge about VC’s is very limited. There are some reports on the toxicity of VC’s (Rhoads et al., 1985, Waters, 1977) and some dealing more specifically with the mechanisms of VC toxicity (Zychlinski et al., 1990, Owusuyaw et al., 1990, Roldan et al., 1990). There is one report which suggests a similar mechanism of vanadium-5-oxide reduction as it is described for dichromates (Shi et al., 1990). We therefore investigated different VC’s in a pneumocyte cell culture system and compared the results with the effects of dichromate.
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- Comparison of chromate and vanadate toxicity and its relationship to oxygen radical formation
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