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Journal of Coatings Technology and Research
Erschienen in: Journal of Coatings Technology and Research 2/2019

23.07.2018

Composite PCL/HA/simvastatin electrospun nanofiber coating on biodegradable Mg alloy for orthopedic implant application

verfasst von: Abdelrahman I. Rezk, Hamouda M. Mousa, Joshua Lee, Chan Hee Park, Cheol Sang Kim

Erschienen in: Journal of Coatings Technology and Research | Ausgabe 2/2019

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Abstract

Recently, magnesium (Mg) and its alloys have attracted more attention because of their biodegradability and fascinating mechanical properties in the medical field. However, their low corrosion resistance and high degradability in the body have a great effect on mechanical stability and cytocompatibility, which hinders its clinical applications. Therefore, here we introduce a bifunctional composite coating composed of polycaprolactone and synthesized hydroxyapatite nanoparticles (HA-NPs) loaded with simvastatin deposited on the AZ31 alloy via electrospinning technique. The synthesized HA-NPs and composite nanofibers layer were characterized using TEM, FE-SEM, FTIR, and XRD to understand the physiochemical properties of the composite nanofibers compared to pristine polymer and bare alloy. Corrosion resistance was evaluated electrochemically using potentiodynamic polarization and EIS measurements, and biodegradability was evaluated in terms of pH and Mg ions release in SBF solution. The as-prepared coating was found to retard the corrosion and increased the osteocompatibility as resulted in cell culture test, a higher cell attachment and proliferation on the implant biointerface, in addition to releasing simvastatin in a controlled platform.
Vorheriger Artikel UV-curable alkyd coating with self-healing ability
Nächster Artikel Heat dissipation on electrical conductor composites by combination of carbon nanotubes and graphene nanoplatelets

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Metadaten
Titel
Composite PCL/HA/simvastatin electrospun nanofiber coating on biodegradable Mg alloy for orthopedic implant application
verfasst von
Abdelrahman I. Rezk
Hamouda M. Mousa
Joshua Lee
Chan Hee Park
Cheol Sang Kim
Publikationsdatum
23.07.2018
Verlag
Springer US
Erschienen in
Journal of Coatings Technology and Research / Ausgabe 2/2019
Print ISSN: 1547-0091
Elektronische ISSN: 1935-3804
DOI
https://doi.org/10.1007/s11998-018-0126-8

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